{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:42:53Z","timestamp":1769168573165,"version":"3.49.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>Mutations in the CLN3 gene cause a fatal neurodegenerative disorder: juvenile CLN3 disease, also known as juvenile Batten disease. The two most commonly utilized mouse models of juvenile CLN3 disease are Cln3-knockout (Cln3\u2212\/\u2212) and Cln3\u0394ex7\/8-knock-in mice, the latter mimicking the most frequent disease-causing human mutation. To determine which mouse model has the most pronounced neurological phenotypes that can be used as outcome measures for therapeutic studies, we compared the exploratory activity, motor function and depressive-like behavior of 1-, 3- and 6-month-old Cln3\u2212\/\u2212 and Cln3\u0394ex7\/8-knock-in mice on two different genetic backgrounds (129S6\/SvEv and C57BL\/6J). Although, in many cases, the behavior of Cln3\u2212\/\u2212 and Cln3\u0394ex7\/8 mice was similar, we found genetic-background-, gender- and age-dependent differences between the two mouse models. We also observed large differences in the behavior of the 129S6\/SvEv and C57BL\/6J wild-type strains, which highlights the strong influence that genetic background can have on phenotype. Based on our results, Cln3\u2212\/\u2212 male mice on the 129S6\/SvEv genetic background are the most appropriate candidates for therapeutic studies. They exhibit motor deficits at 1 and 6 months of age in the vertical pole test, and they were the only mice to show impaired motor coordination in the rotarod test at both 3 and 6 months. Cln3\u2212\/\u2212 males on the C57BL\/6J background and Cln3\u0394ex7\/8 males on the 129S6\/SvEv background also provide good outcome measures for therapeutic interventions. Cln3\u2212\/\u2212 (C57BL\/6J) males had serious difficulties in climbing down (at 1 and 6 months) and turning downward on (at 1, 3 and 6 months) the vertical pole, whereas Cln3\u0394ex7\/8 (129S6\/SvEv) males climbed down the vertical pole drastically slower than wild-type males at 3 and 6 months of age. Our study demonstrates the importance of testing mouse models on different genetic backgrounds and comparing males and females in order to find the most appropriate disease model for therapeutic studies.<\/jats:p>","DOI":"10.1242\/dmm.018804","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T17:13:52Z","timestamp":1427908432000},"page":"351-361","source":"Crossref","is-referenced-by-count":50,"title":["Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender"],"prefix":"10.1242","volume":"8","author":[{"given":"Attila D.","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Sanford Children\u2019s Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Sanford Children\u2019s Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA."},{"name":"Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042501190086900_b1-0080351","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/14660820500443000","article-title":"Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes","volume":"7","author":"Abramow-Newerly","year":"2006","journal-title":"Amyotroph. Lateral Scler."},{"key":"2021042501190086900_b2-0080351","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0006-8993(99)01586-3","article-title":"A behavioral and neuroanatomical assessment of an inbred substrain of 129 mice with behavioral comparisons to C57BL\/6J mice","volume":"836","author":"Balogh","year":"1999","journal-title":"Brain Res."},{"key":"2021042501190086900_b3-0080351","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ana.22162","article-title":"N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1\u2212\/\u2212 mouse","volume":"69","author":"Berman","year":"2011","journal-title":"Ann. Neurol."},{"key":"2021042501190086900_b4-0080351","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1523\/JNEUROSCI.23-12-05105.2003","article-title":"Factors in the genetic background suppress the engrailed-1 cerebellar phenotype","volume":"23","author":"Bilovocky","year":"2003","journal-title":"J. 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Genet."},{"key":"2021042501190086900_b7-0080351","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2990.2008.00984.x","article-title":"Altered arginine metabolism in the central nervous system (CNS) of the Cln3\u2212\/\u2212 mouse model of juvenile Batten disease","volume":"35","author":"Chan","year":"2009","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"2021042501190086900_b8-0080351","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.physbeh.2004.02.006","article-title":"Genetic vulnerability to diet-induced obesity in the C57BL\/6J mouse: physiological and molecular characteristics","volume":"81","author":"Collins","year":"2004","journal-title":"Physiol. 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Chem."},{"key":"2021042501190086900_b44-0080351","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.brainres.2004.07.030","article-title":"Late onset neurodegeneration in the Cln3\u2212\/\u2212 mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation","volume":"1023","author":"Pontikis","year":"2004","journal-title":"Brain Res."},{"key":"2021042501190086900_b45-0080351","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.nbd.2005.05.018","article-title":"Thalamocortical neuron loss and localized astrocytosis in the Cln3Deltaex7\/8 knock-in mouse model of Batten disease","volume":"20","author":"Pontikis","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"2021042501190086900_b46-0080351","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0166-4328(02)00376-5","article-title":"Influence of task parameters on rotarod performance and sensitivity to ethanol in mice","volume":"141","author":"Rustay","year":"2003","journal-title":"Behav. Brain Res."},{"key":"2021042501190086900_b47-0080351","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.bbadis.2013.04.008","article-title":"NCL diseases - clinical perspectives","author":"Schulz","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042501190086900_b48-0080351","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneuroim.2010.08.024","article-title":"Immunosuppression alters disease severity in juvenile Batten disease mice","volume":"230","author":"Seehafer","year":"2011","journal-title":"J. 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