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Tomoregulin-1 is a growth factor that is primarily involved in embryonic development and adult central nervous system (CNS) function, and it is expressed abnormally in a variety of CNS pathologies.Tomoregulin-1 is also expressed in the myocardium. However, the effects of Tomoregulin-1 on the heart, particularly on cardiac hypertrophy, remains unknown. The aim of the study is to examine whether and by what mechanism Tomoregulin-1 regulates the development of cardiac hypertrophy induced by pressure overload. In this study, we found that Tomoregulin-1 was significantly up-regulated in two cardiac hypertrophy models, the cTnTR92Q transgenic mice and the thoracic aorta constriction (TAC)-induced cardiac hypertrophy mice. The transgenic overexpression of Tomoregulin-1 increased the survival rate, improved the cardiac geometry and functional parameters of echocardiography and decreased the degree of cardiac hypertrophy of the TAC mice, whereas knockdown of Tomoregulin-1 expression resulted in an opposite phenotype and exacerbated phenotypes of cardiac hypertrophy induced by TAC. A possible mechanism by which Tomoregulin-1 regulates the development of cardiac hypertrophy in TAC-induced cardiac hypertrophy is through inhibiting TGF\u03b2 non-canonical (TAK1-JNK) pathways in the myocardium. Tomoregulin-1 plays a protective role in the modulation of adverse cardiac remodeling from pressure overload in mice. Tomoregulin-1 could be a therapeutic target to control the development of cardiac hypertrophy.<\/jats:p>","DOI":"10.1242\/dmm.021303","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T02:47:05Z","timestamp":1434682025000},"source":"Crossref","is-referenced-by-count":9,"title":["Tomoregulin-1 inhibits cardiac hypertrophy after pressure overload via TAK1-JNK pathways in mice"],"prefix":"10.1242","author":[{"given":"Dan","family":"Bao","sequence":"first","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Dong","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042612514172300_DMM021303C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0012-1606(02)00075-1","article-title":"Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms","volume":"255","author":"Chang","year":"2003","journal-title":"Dev. 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