{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:14:18Z","timestamp":1762866858096,"version":"3.37.3"},"reference-count":64,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":1556,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry Of Science And Technology","doi-asserted-by":"publisher","award":["BT\/PR12849\/MED\/15\/35\/2009","BT\/PR5138\/BRB\/10\/1064\/2012","BT\/PR-14592\/BRB\/10\/858\/2010","BT\/PR\/14651\/MED\/30\/566\/2010","BT\/PR14420\/Med\/29\/213\/2010","BT\/Bio-CARe\/08\/48\/2010-2011"],"award-info":[{"award-number":["BT\/PR12849\/MED\/15\/35\/2009","BT\/PR5138\/BRB\/10\/1064\/2012","BT\/PR-14592\/BRB\/10\/858\/2010","BT\/PR\/14651\/MED\/30\/566\/2010","BT\/PR14420\/Med\/29\/213\/2010","BT\/Bio-CARe\/08\/48\/2010-2011"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry Of Science And Technology","doi-asserted-by":"publisher","award":["SR\/SO\/BB-0035\/2013","SR\/SO\/HS-0005\/2011"],"award-info":[{"award-number":["SR\/SO\/BB-0035\/2013","SR\/SO\/HS-0005\/2011"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["500094\/Z\/09\/Z"],"award-info":[{"award-number":["500094\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"DBT India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Transient albuminuria induced by pathogen-associated molecular patterns (PAMPs) in mice through engagement of Toll-like receptors (TLRs) is widely studied as a partial model for some forms of human nephrotic syndrome (NS). In addition to TLRs, CD80 has been shown to be essential for PAMP-mediated albuminuria. However, the mechanistic relationships between TLRs, CD80 and albuminuria remain unclear. Here, we show that albuminuria and CD80-uria induced in mice by many TLR ligands are dependent on the expression of TLRs and their downstream signalling intermediate MyD88 exclusively in hematopoietic cells and, conversely, on CD80 expression exclusively in non-hematopoietic cells. TNF\u03b1 is crucial for TLR-mediated albuminuria and CD80-uria, and induces CD80 expression in cultured renal podocytes. IL-10 from hematopoietic cells ameliorates TNF\u03b1 production, albuminuria and CD80-uria but does not prevent TNF\u03b1-mediated induction of podocyte CD80 expression. Chitohexaose, a small molecule originally of parasite origin, mediates TLR4-dependent anti-inflammatory responses, and blocks TLR-mediated albuminuria and CD80-uria through IL-10. Thus, TNF\u03b1 is a prominent mediator of renal CD80 induction and resultant albuminuria in this model, and small molecules modulating TLR-mediated inflammatory activation might have contributory or adjunct therapeutic potential in some contexts of NS development.<\/jats:p>","DOI":"10.1242\/dmm.023440","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T02:34:33Z","timestamp":1461897273000},"page":"707-717","source":"Crossref","is-referenced-by-count":11,"title":["TLR-mediated albuminuria needs TNF\u03b1-mediated cooperativity between TLRs present in hematopoietic tissues and CD80 present on non-hematopoietic tissues in mice"],"prefix":"10.1242","volume":"9","author":[{"given":"Nidhi","family":"Jain","sequence":"first","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavya","family":"Khullar","sequence":"additional","affiliation":[{"name":"Pediatric Biology Center, Translational Health Sciences and Technology Institute 2 , Faridabad 121001, National Capital Region , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Oswal","sequence":"additional","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balaji","family":"Banoth","sequence":"additional","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Joshi","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences 3 Department of Pathology , , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balachandran","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences 4 , Bhubaneswar , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subrat","family":"Panda","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences 3 Department of Pathology , , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumen","family":"Basak","sequence":"additional","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"George","sequence":"additional","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyajit","family":"Rath","sequence":"additional","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"},{"name":"Pediatric Biology Center, Translational Health Sciences and Technology Institute 2 , Faridabad 121001, National Capital Region , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-2045","authenticated-orcid":false,"given":"Vineeta","family":"Bal","sequence":"additional","affiliation":[{"name":"National Institute of Immunology 1 , New Delhi 110067 , India"},{"name":"Pediatric Biology Center, Translational Health Sciences and Technology Institute 2 , Faridabad 121001, National Capital Region , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailaja","family":"Sopory","sequence":"additional","affiliation":[{"name":"Pediatric Biology Center, Translational Health Sciences and Technology Institute 2 , Faridabad 121001, National Capital Region , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2024061302550773700_DMM023440C1","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1053\/j.ajkd.2009.03.019","article-title":"Idiopathic nephrotic syndrome and atopy: is there a common link?","volume":"54","author":"Abdel-Hafez","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"2024061302550773700_DMM023440C2","doi-asserted-by":"publisher","first-page":"F1624","DOI":"10.1152\/ajprenal.00032.2008","article-title":"Serum- and glucocorticoid-inducible kinase 1 in doxorubicin-induced nephrotic syndrome","volume":"295","author":"Artunc","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2024061302550773700_DMM023440C3","first-page":"13","article-title":"Nephrotic syndrome in children","volume":"122","author":"Bagga","year":"2005","journal-title":"Indian J. Med. Res."},{"key":"2024061302550773700_DMM023440C4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00467-003-1122-4","article-title":"Tumor necrosis factor-alpha production from mononuclear cells in nephrotic syndrome","volume":"18","author":"Bakr","year":"2003","journal-title":"Pediatr. Nephrol. Berl. Ger."},{"key":"2024061302550773700_DMM023440C5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.1365-2249.2005.02905.x","article-title":"The costimulatory molecules CD80, CD86 and OX40L are up-regulated in Aspergillus fumigatus sensitized mice","volume":"142","author":"Barrios","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"2024061302550773700_DMM023440C6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cell.2006.12.033","article-title":"A fourth IkappaB protein within the NF-kappaB signaling module","volume":"128","author":"Basak","year":"2007","journal-title":"Cell"},{"key":"2024061302550773700_DMM023440C7","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1172\/JCI118290","article-title":"Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance","volume":"96","author":"Berg","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2024061302550773700_DMM023440C8","first-page":"135","article-title":"Mouse models of membranous nephropathy: the road less travelled by","volume":"2","author":"Borza","year":"2013","journal-title":"Am. J. Clin. Exp. Immunol."},{"key":"2024061302550773700_DMM023440C9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1365-2249.1992.tb06423.x","article-title":"IL-1-like production in adriamycin-induced nephrotic syndrome in the rat","volume":"87","author":"Bricio","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"2024061302550773700_DMM023440C10","doi-asserted-by":"publisher","first-page":"F127","DOI":"10.1152\/ajprenal.00108.2012","article-title":"B7\u20131 expression regulates the hypoxia-driven cytoskeleton rearrangement in glomerular podocytes","volume":"304","author":"Chang","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2024061302550773700_DMM023440C11","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1159\/000072065","article-title":"Interleukin-8 and tumor necrosis factor-alpha are increased in minimal change disease but do not alter albumin permeability","volume":"23","author":"Cho","year":"2003","journal-title":"Am. J. Nephrol."},{"key":"2024061302550773700_DMM023440C12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nm.2261","article-title":"Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome","volume":"17","author":"Clement","year":"2011","journal-title":"Nat. Med."},{"key":"2024061302550773700_DMM023440C13","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.4049\/jimmunol.172.4.2629","article-title":"Role of Toll-like receptor 4 in endotoxin-induced acute renal failure","volume":"172","author":"Cunningham","year":"2004","journal-title":"J. Immunol."},{"key":"2024061302550773700_DMM023440C14","doi-asserted-by":"publisher","first-page":"6491","DOI":"10.4049\/jimmunol.166.11.6491","article-title":"Mechanism of melphalan-induced B7\u20131 gene expression in P815 tumor cells","volume":"166","author":"Donepudi","year":"2001","journal-title":"J. Immunol."},{"key":"2024061302550773700_DMM023440C15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1553-2712.2011.01266.x","article-title":"Point-of-care urine albumin:creatinine ratio is associated with outcome in emergency department patients with sepsis: a pilot study","volume":"19","author":"Drumheller","year":"2012","journal-title":"Acad. Emerg. Med."},{"key":"2024061302550773700_DMM023440C16","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(03)14184-0","article-title":"Nephrotic syndrome in childhood","volume":"362","author":"Eddy","year":"2003","journal-title":"Lancet"},{"key":"2024061302550773700_DMM023440C17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.burns.2012.10.006","article-title":"Detection of microalbuminuria: a simple test for prognosis in severe burns","volume":"39","author":"Emara","year":"2013","journal-title":"Burns"},{"key":"2024061302550773700_DMM023440C18","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1681\/ASN.V133788","article-title":"Glomerular-specific gene excision in vivo","volume":"13","author":"Eremina","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"2024061302550773700_DMM023440C19","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1159\/000329575","article-title":"Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes","volume":"119","author":"Eyre","year":"2011","journal-title":"Nephron Exp. Nephrol."},{"key":"2024061302550773700_DMM023440C20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bcp.2014.02.016","article-title":"Pentamethoxyflavanone regulates macrophage polarization and ameliorates sepsis in mice","volume":"89","author":"Feng","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"2024061302550773700_DMM023440C21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1681\/ASN.2007080836","article-title":"Urinary CD80 excretion increases in idiopathic minimal-change disease","volume":"20","author":"Garin","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"2024061302550773700_DMM023440C22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev-physiol-020911-153238","article-title":"Cell biology and pathology of podocytes","volume":"74","author":"Greka","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"2024061302550773700_DMM023440C23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/path.4235","article-title":"Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria","volume":"231","author":"Gurkan","year":"2013","journal-title":"J. Pathol."},{"key":"2024061302550773700_DMM023440C24","doi-asserted-by":"publisher","first-page":"317852","DOI":"10.1155\/2011\/317852","article-title":"Tyrosine kinase signaling in kidney glomerular podocytes","volume":"2011","author":"Hattori","year":"2011","journal-title":"J. Signal Transduct."},{"key":"2024061302550773700_DMM023440C25","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1365-3083.2010.02499.x","article-title":"Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection","volume":"73","author":"Hotoura","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"2024061302550773700_DMM023440C26","first-page":"35","article-title":"Management of steroid resistant nephrotic syndrome","volume":"46","author":"Indian Society of Pediatric Nephrology","year":"2009","journal-title":"Indian Pediatr."},{"key":"2024061302550773700_DMM023440C27","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.1073\/pnas.1321427111","article-title":"T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation","volume":"111","author":"Inoue","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061302550773700_DMM023440C28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.semnephrol.2011.06.002","article-title":"Minimal change disease: a CD80 podocytopathy?","volume":"31","author":"Ishimoto","year":"2011","journal-title":"Semin. Nephrol."},{"key":"2024061302550773700_DMM023440C29","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1093\/ndt\/gfs543","article-title":"Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice","volume":"28","author":"Ishimoto","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"2024061302550773700_DMM023440C30","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1007\/s00467-013-2498-4","article-title":"Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes","volume":"28","author":"Ishimoto","year":"2013","journal-title":"Pediatr. Nephrol."},{"key":"2024061302550773700_DMM023440C31","first-page":"14","article-title":"[Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure]","volume":"78","author":"Koriakova","year":"2006","journal-title":"Ter. Arkhiv"},{"key":"2024061302550773700_DMM023440C32","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1681\/ASN.2006070710","article-title":"Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats","volume":"18","author":"Lai","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"2024061302550773700_DMM023440C33","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1053\/ajkd.2002.32769","article-title":"T-lymphocyte populations and cytokines in childhood nephrotic syndrome","volume":"39","author":"Lama","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"2024061302550773700_DMM023440C34","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0002-9440(10)65427-2","article-title":"Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure","volume":"154","author":"Leifeld","year":"1999","journal-title":"Am. J. Pathol."},{"key":"2024061302550773700_DMM023440C35","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"2024061302550773700_DMM023440C36","first-page":"1024","article-title":"Tumor necrosis factor alpha and interleukin 6 in infants with sepsis","volume":"42","author":"Makhija","year":"2005","journal-title":"Indian Pediatr."},{"key":"2024061302550773700_DMM023440C37","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/BF01708964","article-title":"Prognostic values of serum cytokines in septic shock","volume":"20","author":"Martin","year":"1994","journal-title":"Intensive Care Med."},{"key":"2024061302550773700_DMM023440C38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000prime Rep."},{"key":"2024061302550773700_DMM023440C39","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.2215\/CJN.03800609","article-title":"Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis","volume":"5","author":"McCarthy","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2024061302550773700_DMM023440C40","doi-asserted-by":"publisher","first-page":"F1070","DOI":"10.1152\/ajprenal.00365.2011","article-title":"Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats","volume":"303","author":"Muroya","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2024061302550773700_DMM023440C41","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/j.humpath.2010.01.021","article-title":"Minimal-change nephrotic syndrome preceding Hodgkin lymphoma by 5 years with expression of tumor necrosis factor alpha in Hodgkin-Reed-Sternberg cells","volume":"41","author":"Nakayama","year":"2010","journal-title":"Hum. Pathol."},{"key":"2024061302550773700_DMM023440C42","doi-asserted-by":"publisher","first-page":"e1002717","DOI":"10.1371\/journal.ppat.1002717","article-title":"Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks endotoxemia","volume":"8","author":"Panda","year":"2012","journal-title":"PLoS Pathog."},{"key":"2024061302550773700_DMM023440C43","doi-asserted-by":"publisher","first-page":"e206","DOI":"10.1111\/j.1365-2567.2008.02948.x","article-title":"Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier","volume":"128","author":"Pawar","year":"2009","journal-title":"Immunology"},{"key":"2024061302550773700_DMM023440C44","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"2024061302550773700_DMM023440C45","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00467-004-1573-2","article-title":"Tumor necrosis factor-alpha blocking agent as a treatment for nephrotic syndrome","volume":"19","author":"Raveh","year":"2004","journal-title":"Pediatr. Nephrol."},{"key":"2024061302550773700_DMM023440C46","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nm0111-44","article-title":"Filtering new facts about kidney disease","volume":"17","author":"Reiser","year":"2011","journal-title":"Nat. Med."},{"key":"2024061302550773700_DMM023440C47","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1172\/JCI20402","article-title":"Induction of B7-1 in podocytes is associated with nephrotic syndrome","volume":"113","author":"Reiser","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2024061302550773700_DMM023440C48","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nrneph.2013.274","article-title":"Signal transduction in podocytes--spotlight on receptor tyrosine kinases","volume":"10","author":"Reiser","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"2024061302550773700_DMM023440C49","first-page":"993","article-title":"Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome","volume":"11","author":"Rizk","year":"2005","journal-title":"East. Mediterr. Health J."},{"key":"2024061302550773700_DMM023440C50","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/path.2979","article-title":"Tumour necrosis factor-\u03b1 drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis","volume":"226","author":"Ryu","year":"2012","journal-title":"J. Pathol."},{"key":"2024061302550773700_DMM023440C51","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00281-013-0415-3","article-title":"Immunopathogenesis of idiopathic nephrotic syndrome with relapse","volume":"36","author":"Sahali","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"2024061302550773700_DMM023440C52","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/ki.2012.62","article-title":"Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney","volume":"82","author":"Schreiber","year":"2012","journal-title":"Kidney Int."},{"key":"2024061302550773700_DMM023440C53","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00467-010-1676-x","article-title":"Minimal change disease: a \u201ctwo-hit\u201d podocyte immune disorder?","volume":"26","author":"Shimada","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"2024061302550773700_DMM023440C54","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1093\/ndt\/gfr271","article-title":"Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-{kappa}B-dependent pathway","volume":"27","author":"Shimada","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"2024061302550773700_DMM023440C55","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12079-012-0184-0","article-title":"LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile","volume":"7","author":"Srivastava","year":"2013","journal-title":"J. Cell Commun. Signal."},{"key":"2024061302550773700_DMM023440C56","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0272-6386(12)80742-6","article-title":"Elevated levels of tumor necrosis factor-alpha in the nephrotic syndrome in humans","volume":"21","author":"Suranyi","year":"1993","journal-title":"Am. J. Kidney Dis."},{"key":"2024061302550773700_DMM023440C57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"2024061302550773700_DMM023440C58","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nm1696","article-title":"Modification of kidney barrier function by the urokinase receptor","volume":"14","author":"Wei","year":"2008","journal-title":"Nat. Med."},{"key":"2024061302550773700_DMM023440C59","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"2024061302550773700_DMM023440C60","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s004670100024","article-title":"Risk factors for steroid dependency in children with idiopathic nephrotic syndrome","volume":"16","author":"Yap","year":"2001","journal-title":"Pediatr. Nephrol."},{"key":"2024061302550773700_DMM023440C61","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1056\/nejmoa1304572","article-title":"Abatacept in B7-1\u2013positive proteinuric kidney disease","volume":"369","author":"Yu","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"2024061302550773700_DMM023440C62","doi-asserted-by":"publisher","first-page":"ra39","DOI":"10.1126\/scisignal.2000678","article-title":"c-mip impairs podocyte proximal signaling and induces heavy proteinuria","volume":"3","author":"Zhang","year":"2010","journal-title":"Sci. Signal."},{"key":"2024061302550773700_DMM023440C63","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1084\/jem.183.3.777","article-title":"A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB","volume":"183","author":"Zhao","year":"1996","journal-title":"J. Exp. Med."},{"key":"2024061302550773700_DMM023440C64","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.cellsig.2013.11.004","article-title":"Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways","volume":"26","author":"Zhou","year":"2014","journal-title":"Cell. Signal."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dmm.023440","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/9\/6\/707\/3485981\/dmm023440.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.023440\/2069154\/dmm_023440v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/9\/6\/707\/3485981\/dmm023440.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T02:55:26Z","timestamp":1718247326000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/9\/6\/707\/20123\/TLR-mediated-albuminuria-needs-TNF-mediated"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.023440","relation":{},"ISSN":["1754-8411","1754-8403"],"issn-type":[{"type":"electronic","value":"1754-8411"},{"type":"print","value":"1754-8403"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}