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The vast majority of lupus research has focused on either the contributions of immune cell dysfunction or the genetics of the disease. Because granulocytes isolated from human SLE patients had alterations in neutrophil nuclear morphology that resembled the Pelger-Huet Anomaly, and had prominent mis-splicing of mRNA encoding the nuclear membrane protein Lamin B receptor (LBR), consistent with their Pelger-Huet-like nuclear morphology, we used a novel mouse model system to test the hypothesis that a disruption in the structure of nucleus itself also contributes to the development of lupus autoimmunity. The lupus-prone mouse strain New Zealand White (NZW) was crossed with c57Bl\/6 mice harboring a heterozygous autosomal dominant mutation in Lbr (B6.Lbric\/+), and the (NZW\u00d7B6.Lbric)F1 offspring were evaluated for induction of lupus autoimmunity. Only female (NZW\u00d7B6.Lbric)F1 mice developed lupus autoimmunity, which included splenomegaly, kidney damage, and autoantibodies. Kidney damage was accompanied by immune complex deposition, and perivascular and tubule infiltration of mononuclear cells. The titers of anti-chromatin antibodies exceeded those of aged female MRL-Faslpr mice, and were predominantly of the IgG2 subclasses. The anti-nuclear antibody staining profile of female (NZW\u00d7B6.Lbric)F1 sera was complex, and consisted of an anti-nuclear membrane reactivity that co-localized with the A-type lamina, in combination with a homogeneous pattern that was related to the recognition of histones with covalent modifications that are associated with gene activation. An anti-neutrophil IgM recognizing calreticulin, but not myeloperoxidase (MPO) or proteinase 3 (PR3), was also identified. Thus, alterations in nuclear structure contribute to lupus autoimmunity when expressed in the context of a lupus-prone genetic background, suggesting a mechanism for the development of lupus autoimmunity in genetically-predisposed individuals that is induced by the disruption of nuclear architecture.<\/jats:p>","DOI":"10.1242\/dmm.024851","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:59:06Z","timestamp":1465520346000},"source":"Crossref","is-referenced-by-count":7,"title":["Alterations in nuclear structure promote lupus autoimmunity in a mouse model"],"prefix":"10.1242","author":[{"given":"Namrata","family":"Singh","sequence":"first","affiliation":[{"name":"Internal Medicine, University of Iowa, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan B.","family":"Johnstone","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Internal Medicine, Temple University School of Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology, Fels Institute for Cancer Research, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo","family":"Tempera","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology, Fels Institute for Cancer Research, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana J.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-1744","authenticated-orcid":false,"given":"Michael F.","family":"Denny","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Temple University School of Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042501242122400_DMM024851C1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/gene.2014.23","article-title":"GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region","volume":"15","author":"Armstrong","year":"2014","journal-title":"Genes Immun."},{"key":"2021042501242122400_DMM024851C2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1084\/jem.20021553","article-title":"Interferon and granulopoiesis signatures in systemic lupus erythematosus blood","volume":"197","author":"Bennett","year":"2003","journal-title":"J. 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