{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:13:54Z","timestamp":1790266434975,"version":"4.1.0"},"reference-count":71,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1598,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0028-01"],"award-info":[{"award-number":["ANR-11-LABX-0028-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-BSV4-0020"],"award-info":[{"award-number":["ANR-12-BSV4-0020"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-SVSE8-0022"],"award-info":[{"award-number":["ANR-12-SVSE8-0022"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007380","name":"Fondation Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20140329490"],"award-info":[{"award-number":["DEQ20140329490"]}],"id":[{"id":"10.13039\/100007380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>CYtoplasmic FMRP Interacting Protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID), autism, schizophrenia and epilepsy. It is a member of a family of proteins that is very conserved during evolution, sharing high homology with dCYFIP, its Drosophila homolog. CYFIP1 interacts with the Fragile X Mental Retardation Protein (FMRP), whose absence causes the Fragile X Syndrome, and with the translation initiation factor eIF4E. It is a member of the WAVE Regulatory Complex (WRC), thus representing a link between translational regulation and actin cytoskeleton. Here, we present data showing a correlation between mRNA levels of CYFIP1 and other members of the WRC. This suggests a tight regulation of the levels of the WRC members not only by post-translational mechanisms, as previously hypothesized. Moreover, we studied the impact of loss of function of both CYFIP1 and FMRP on neuronal growth and differentiation in two animal models, fly and mouse. We show that these two proteins antagonize each other\u2019s function not only during neuromuscular junction growth in the fly but also during new neuronal differentiation in the olfactory bulb of adult mice. Mechanistically, FMRP and CYFIP1 modulate mTor signaling in an antagonistic manner, likely via independent pathways, supporting the results obtained in mouse as well as in fly at the morphological level. Collectively, our results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction.<\/jats:p>","DOI":"10.1242\/dmm.025809","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T01:40:22Z","timestamp":1486690822000},"source":"Crossref","is-referenced-by-count":45,"title":["New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-2307","authenticated-orcid":false,"given":"Sabiha","family":"Abekhoukh","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Nice, FRANCE"},{"name":"CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology, 06560 Valbonne, FRANCE"},{"name":"Associated Intenational Laboratory (LIA) \u2018Neogenex\u2019, 06560 Valbonne, FRANCE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-7637","authenticated-orcid":false,"given":"H Bahar","family":"Sahin","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Illkirch, FRANCE"},{"name":"Centre National de la Recherche Scientifique, UMR7104, Illkirch, FRANCE"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U964, Illkirch, FRANCE"},{"name":"Universit\u00e9 de Strasbourg, Illkirch, FRANCE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-7925","authenticated-orcid":false,"given":"Mauro","family":"Grossi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Nice, FRANCE"},{"name":"CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology, 06560 Valbonne, FRANCE"},{"name":"Associated Intenational Laboratory (LIA) \u2018Neogenex\u2019, 06560 Valbonne, FRANCE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Zongaro","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Nice, FRANCE"},{"name":"CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology, 06560 Valbonne, FRANCE"},{"name":"Associated Intenational Laboratory (LIA) \u2018Neogenex\u2019, 06560 Valbonne, FRANCE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-3135","authenticated-orcid":false,"given":"Thomas","family":"Maurin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, Nice, FRANCE"},{"name":"CNRS UMR 7275, Institute of Molecular and Cellular Pharmacology, 06560 Valbonne, FRANCE"},{"name":"Associated Intenational Laboratory (LIA) \u2018Neogenex\u2019, 06560 Valbonne, 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