{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:21:53Z","timestamp":1770488513642,"version":"3.49.0"},"reference-count":63,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1598,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"name":"Simons Foundation for Autism Research","award":["Pilot Award 346154"],"award-info":[{"award-number":["Pilot Award 346154"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Mutations in MECP2 cause Rett syndrome, a severe neurological disorder with autism-like features. Duplication of MECP2 also causes severe neuropathology. Both diseases display immunological abnormalities that suggest a role for MeCP2 in controlling immune and inflammatory responses. Here, we used mecp2-null zebrafish to study the potential function of Mecp2 as an immunological regulator. Mecp2-deficiency resulted in an increase in neutrophil infiltration and upregulated expression of the pro- and anti-inflammatory cytokines Il1b and Il10 as a secondary response to disturbances in tissue homeostasis. In contrast, expression of the pro-inflammatory cytokine tumor necrosis factor alpha (Tnfa) was consistently downregulated in mecp2\u00ad-null animals during development, representing the earliest developmental phenotype described for MeCP2-deficiency to date. Expression of tnfa was unresponsive to inflammatory stimulation, and was partially restored by re-expression of functional mecp2. Thus, Mecp2 is required for tnfa expression during zebrafish development and inflammation. Finally, RNA sequencing of mecp2-null embryos revealed dysregulated processes predictive for Rett syndrome phenotypes.<\/jats:p>","DOI":"10.1242\/dmm.026922","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:10:21Z","timestamp":1507594221000},"source":"Crossref","is-referenced-by-count":25,"title":["Mecp2 regulates<i>tnfa<\/i>during zebrafish embryonic development and acute inflammation"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-7088","authenticated-orcid":false,"given":"M.","family":"van der Vaart","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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