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Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we characterise immune-mediated cardiac tissue damage in a new model of SLE induced by topical application of the Toll-like receptor 7\/8 (TLR7\/8) agonist Resiquimod. We observe a cardiac phenotype reminiscent of autoimmune-mediated dilated cardiomyopathy, and identify auto-antibodies as major contributors to cardiac tissue damage. Resiquimod-induced heart disease is a highly relevant mouse model for mechanistic and therapeutic studies aiming to protect the heart during autoimmunity.<\/jats:p>","DOI":"10.1242\/dmm.027409","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T14:25:14Z","timestamp":1488378314000},"page":"259-270","source":"Crossref","is-referenced-by-count":60,"title":["Systemic autoimmunity induced by the TLR7\/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease"],"prefix":"10.1242","volume":"10","author":[{"given":"Muneer G.","family":"Hasham","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta","family":"Baxan","sequence":"additional","affiliation":[{"name":"Biological Imaging Centre, Department of Medicine, Imperial College London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Stuckey","sequence":"additional","affiliation":[{"name":"Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London WC1E 6DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Branca","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryant","family":"Perkins","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dent","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Duffy","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolani S.","family":"Hameed","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Stella","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Bellahcene","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Schneider","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian E.","family":"Harding","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA"},{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-4109","authenticated-orcid":false,"given":"Susanne","family":"Sattler","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College\u2008London, London W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042701353049700_DMM027409C1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.autrev.2005.12.006","article-title":"Inflammation: a pivotal link between autoimmune diseases and atherosclerosis","volume":"5","author":"Abou-Raya","year":"2006","journal-title":"Autoimmun Rev."},{"key":"2021042701353049700_DMM027409C2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/01.crd.0000124843.85660.ed","article-title":"Atherosclerosis and systemic lupus erythematosus","volume":"12","author":"Abusamieh","year":"2004","journal-title":"Cardiol. 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