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Two predominant molecular features of AD, extracellular accumulation of A\u03b2 oligomers and intracellular elevation of AICD levels, have been used to closely inspect the series of signaling events. In their presence, multiple signaling pathways involving ROCK and PAK1 proteins lead to disassembly of the cytoskeleton and Grb2 partially counterbalances the cytoskeletal loss. Increased Grb2-NOX4 interaction plays a preventive role against cytoskeletal disassembly, in turn blocking NOX activity and decreasing the expression of slingshot homolog 1 (SSH-1) protein, a potent inducer of cytoskeleton disassembly. This study unravels a unique role of Grb2 in protecting the cytoskeletal architecture in AD like conditions and presents a potential new strategy for controlling neurodegeneration.<\/jats:p>","DOI":"10.1242\/dmm.027748","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:10:42Z","timestamp":1490919042000},"source":"Crossref","is-referenced-by-count":14,"title":["Cellular levels of growth factor receptor bound protein 2 (Grb2) and cytoskeleton stability are correlated in a neurodegenerative scenario"],"prefix":"10.1242","author":[{"given":"Piyali","family":"Majumder","sequence":"first","affiliation":[{"name":"Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Block-AF, Sector-1, Bidhannagar, Kolkata, WB 700064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasturi","family":"Roy","sequence":"additional","affiliation":[{"name":"Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Block-AF, Sector-1, Bidhannagar, Kolkata, WB 700064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brijesh Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihar Ranjan","family":"Jana","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neuroscience Laboratory, National Brain Research Centre, Manesar, Gurgaon 122 050, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-2260","authenticated-orcid":false,"given":"Debashis","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Block-AF, Sector-1, Bidhannagar, Kolkata, WB 700064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042500124642000_DMM027748C1","doi-asserted-by":"publisher","first-page":"e76792","DOI":"10.1371\/journal.pone.0076792","article-title":"Grb2 is regulated by Foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin","volume":"8","author":"Baksi","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042500124642000_DMM027748C2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/cm.20388","article-title":"Cytoskeletal pathologies of Alzheimer disease","volume":"66","author":"Bamburg","year":"2009","journal-title":"Cell Motil. 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