{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:32:39Z","timestamp":1790811159220,"version":"4.1.0"},"reference-count":71,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1598,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2013-44485"],"award-info":[{"award-number":["BFU2013-44485"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["ERC 294665"],"award-info":[{"award-number":["ERC 294665"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 dAjuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["SRG-535"],"award-info":[{"award-number":["SRG-535"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Seventh Framework Programme","award":["IRBPostPro 2.0 2013"],"award-info":[{"award-number":["IRBPostPro 2.0 2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Myeloproliferative neoplasms (MPNs) of the Philadelphia-negative class comprise polycythemia vera, essential thrombocythemia and primary myelofibrosis (PMF). They are associated with aberrant amounts of myeloid lineage cells in the blood, and in the case of overt PMF, with the development of myelofibrosis in the bone marrow and the failure to produce normal blood cells. These diseases are usually caused by gain-of-function mutations in the kinase JAK2. Here we use Drosophila to investigate the consequences of activation of the JAK2 ortholog in hematopoiesis. We have identified the maturing hemocytes in the lymph gland, the major hematopoietic organ in the fly, as the cell population susceptible to induce hypertrophy upon targeted overexpression of JAK. We show that JAK activates a feed-forward loop including the cytokine-like ligand Upd3 and its receptor Domeless, which are required to induce lymph gland hypertrophy. Moreover, we present evidence that p38 MAPK signalling plays a key role in this process by inducing the expression of the ligand Upd3. Interestingly, we also show that forced activation of the p38 MAPK pathway in maturing hemocytes suffices to generate hypertrophic organs and the appearance of melanotic tumours. Our results illustrate a novel pro-tumorigenic cross-talk between the p38 MAPK pathway and JAK signalling in a Drosophila model of MPNs. Based on the shared molecular mechanisms underlying MPNs in flies and humans, the interplay between Drosophila JAK and p38 signalling pathways unravelled in this work might have translational relevance for human MPNs.<\/jats:p>","DOI":"10.1242\/dmm.028118","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T01:25:18Z","timestamp":1487985918000},"source":"Crossref","is-referenced-by-count":17,"title":["<i>Drosophila<\/i>model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-6219","authenticated-orcid":false,"given":"Ana","family":"Terriente-F\u00e9lix","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Bray","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-4060","authenticated-orcid":false,"given":"Angel R.","family":"Nebreda","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain"},{"name":"ICREA, Pg. Llu\u00eds Companys 23, 08010 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-6444","authenticated-orcid":false,"given":"Marco","family":"Mil\u00e1n","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain"},{"name":"ICREA, Pg. Llu\u00eds Companys 23, 08010 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042513380100400_DMM028118C1","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1128\/MCB.19.3.2322","article-title":"p38 mitogen-activated protein kinase can be involved in transforming growth factor \u03b2 superfamily signal transduction in drosophila wing morphogenesis","volume":"19","author":"Adachi-Yamada","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"2021042513380100400_DMM028118C2","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S1534-5807(03)00244-2","article-title":"Signaling role of hemocytes in Drosophila JAK\/STAT-dependent response to septic injury","volume":"5","author":"Agaisse","year":"2003","journal-title":"Dev. Cell"},{"key":"2021042513380100400_DMM028118C3","doi-asserted-by":"publisher","first-page":"e1005746","DOI":"10.1371\/journal.ppat.1005746","article-title":"Transdifferentiation and proliferation in two distinct hemocyte lineages in Drosophila melanogaster larvae after wasp infection","volume":"12","author":"Anderl","year":"2016","journal-title":"PLoS Pathog."},{"key":"2021042513380100400_DMM028118C4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1242\/jcs.132852","article-title":"G\u03b173B is a downstream effector of JAK\/STAT signalling and a regulator of Rho1 in Drosophila haematopoiesis","volume":"127","author":"Bausek","year":"2014","journal-title":"J. Cell Sci."},{"key":"2021042513380100400_DMM028118C5","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(05)74230-6","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"2021042513380100400_DMM028118C6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ydbio.2009.10.045","article-title":"JAK\/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage","volume":"338","author":"Beebe","year":"2010","journal-title":"Dev. Biol."},{"key":"2021042513380100400_DMM028118C7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"2021042513380100400_DMM028118C8","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/S0960-9822(01)00524-3","article-title":"Identification of the first invertebrate interleukin JAK\/STAT receptor, the Drosophila gene domeless","volume":"11","author":"Brown","year":"2001","journal-title":"Curr. Biol."},{"key":"2021042513380100400_DMM028118C9","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chom.2009.01.003","article-title":"Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation","volume":"5","author":"Buchon","year":"2009","journal-title":"Cell Host Microbe"},{"key":"2021042513380100400_DMM028118C10","doi-asserted-by":"publisher","first-page":"e03189","DOI":"10.7554\/elife.03189","article-title":"The transcriptional response to tumorigenic polarity loss in Drosophila","volume":"4","author":"Bunker","year":"2015","journal-title":"eLife"},{"key":"2021042513380100400_DMM028118C11","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1091\/mbc.E11-05-0400","article-title":"An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance","volume":"22","author":"Cai","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"2021042513380100400_DMM028118C12","doi-asserted-by":"publisher","first-page":"20774","DOI":"10.1073\/pnas.1009223107","article-title":"Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042513380100400_DMM028118C13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.2174\/1874312901206010209","article-title":"The p38 MAPK pathway in rheumatoid arthritis: a sideways look","volume":"6","author":"Clark","year":"2012","journal-title":"Open Rheumatol. J."},{"key":"2021042513380100400_DMM028118C14","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.devcel.2016.01.008","article-title":"Gene dosage imbalance contributes to chromosomal instability-induced tumorigenesis","volume":"36","author":"Clemente-Ruiz","year":"2016","journal-title":"Dev. Cell"},{"key":"2021042513380100400_DMM028118C15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF00341734","article-title":"Characterization of a unique lethal tumorous mutation in Drosophila","volume":"144","author":"Corwin","year":"1976","journal-title":"Mol. Gen. Genet."},{"key":"2021042513380100400_DMM028118C16","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/sj.embor.7400282","article-title":"A Drosophila p38 orthologue is required for environmental stress responses","volume":"5","author":"Craig","year":"2004","journal-title":"EMBO Rep."},{"key":"2021042513380100400_DMM028118C17","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1126\/science.1173164","article-title":"Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection","volume":"325","author":"Cronin","year":"2009","journal-title":"Science"},{"key":"2021042513380100400_DMM028118C18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"2021042513380100400_DMM028118C19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1128\/MCB.00688-09","article-title":"A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1","volume":"30","author":"Cully","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"2021042513380100400_DMM028118C20","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1158\/0008-5472.CAN-10-1731","article-title":"FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis","volume":"71","author":"Desterke","year":"2011","journal-title":"Cancer Res."},{"key":"2021042513380100400_DMM028118C21","doi-asserted-by":"publisher","first-page":"6086","DOI":"10.1128\/MCB.00244-09","article-title":"Upregulation of the Drosophila friend of GATA gene U-shaped by JAK\/STAT signaling maintains lymph gland prohemocyte potency","volume":"29","author":"Gao","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"2021042513380100400_DMM028118C22","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.ccr.2014.02.019","article-title":"Dual function of p38\u03b1 MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival","volume":"25","author":"Gupta","year":"2014","journal-title":"Cancer Cell"},{"key":"2021042513380100400_DMM028118C23","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/ni.1765","article-title":"Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut","volume":"10","author":"Ha","year":"2009","journal-title":"Nat. Immunol."},{"key":"2021042513380100400_DMM028118C24","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1128\/MCB.18.6.3527","article-title":"A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression","volume":"18","author":"Han","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"2021042513380100400_DMM028118C25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00279527","article-title":"The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus","volume":"238","author":"Hanratty","year":"1993","journal-title":"Mol. Gen. Genet."},{"key":"2021042513380100400_DMM028118C26","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1002\/j.1460-2075.1995.tb07285.x","article-title":"Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects","volume":"14","author":"Harrison","year":"1995","journal-title":"EMBO J."},{"key":"2021042513380100400_DMM028118C27","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1093\/emboj\/20.19.5421","article-title":"A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK","volume":"20","author":"Inoue","year":"2001","journal-title":"EMBO J."},{"key":"2021042513380100400_DMM028118C28","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nature03546","article-title":"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera","volume":"434","author":"James","year":"2005","journal-title":"Nature"},{"key":"2021042513380100400_DMM028118C29","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"Jiang","year":"2009","journal-title":"Cell"},{"key":"2021042513380100400_DMM028118C30","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1242\/dev.01837","article-title":"The Drosophila lymph gland as a developmental model of hematopoiesis","volume":"132","author":"Jung","year":"2005","journal-title":"Development"},{"key":"2021042513380100400_DMM028118C31","doi-asserted-by":"publisher","first-page":"E2327","DOI":"10.1073\/pnas.1423074112","article-title":"During Drosophila disc regeneration, JAK\/STAT coordinates cell proliferation with Dilp8-mediated developmental delay","volume":"112","author":"Katsuyama","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042513380100400_DMM028118C32","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1182\/blood-2005-05-1889","article-title":"Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2","volume":"106","author":"Kralovics","year":"2005","journal-title":"Blood"},{"key":"2021042513380100400_DMM028118C33","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1073\/pnas.0436940100","article-title":"Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila","volume":"100","author":"Kurucz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl. 1","key":"2021042513380100400_DMM028118C34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1556\/ABiol.58.2007.Suppl.8","article-title":"Definition of Drosophila hemocyte subsets by cell-type specific antigens","volume":"58","author":"Kurucz","year":"2007","journal-title":"Acta Biol. Hung."},{"key":"2021042513380100400_DMM028118C35","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.ydbio.2008.01.033","article-title":"The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity","volume":"316","author":"Kwon","year":"2008","journal-title":"Dev. Biol."},{"key":"2021042513380100400_DMM028118C36","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1182\/blood-2006-02-002030","article-title":"JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis","volume":"108","author":"Lacout","year":"2006","journal-title":"Blood"},{"key":"2021042513380100400_DMM028118C37","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrc2210","article-title":"Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders","volume":"7","author":"Levine","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"2021042513380100400_DMM028118C38","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1128\/MCB.17.3.1562","article-title":"Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways","volume":"17","author":"Luo","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"2021042513380100400_DMM028118C39","doi-asserted-by":"publisher","first-page":"e1000441","DOI":"10.1371\/journal.pbio.1000441","article-title":"A short receptor downregulates JAK\/STAT signalling to control the Drosophila cellular immune response","volume":"8","author":"Makki","year":"2010","journal-title":"PLoS Biol."},{"key":"2021042513380100400_DMM028118C40","doi-asserted-by":"publisher","first-page":"3044","DOI":"10.1101\/gad.1602607","article-title":"The hematopoietic stem cell and its niche: a comparative view","volume":"21","author":"Martinez-Agosto","year":"2007","journal-title":"Genes Dev."},{"key":"2021042513380100400_DMM028118C41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.blre.2014.06.002","article-title":"The future of JAK inhibition in myelofibrosis and beyond","volume":"28","author":"Mascarenhas","year":"2014","journal-title":"Blood Rev."},{"key":"2021042513380100400_DMM028118C42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1534\/genetics.106.061978","article-title":"Melanotic mutants in Drosophila: pathways and phenotypes","volume":"174","author":"Minakhina","year":"2006","journal-title":"Genetics"},{"key":"2021042513380100400_DMM028118C43","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ydbio.2011.01.035","article-title":"JAK\/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila","volume":"352","author":"Minakhina","year":"2011","journal-title":"Dev. Biol."},{"key":"2021042513380100400_DMM028118C44","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.cell.2011.11.041","article-title":"Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance","volume":"147","author":"Mondal","year":"2011","journal-title":"Cell"},{"key":"2021042513380100400_DMM028118C45","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1038\/sj.onc.1208487","article-title":"Opposing roles for Drosophila JAK\/STAT signalling during cellular proliferation","volume":"24","author":"Mukherjee","year":"2005","journal-title":"Oncogene"},{"key":"2021042513380100400_DMM028118C46","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nature03869","article-title":"Identification of JAK\/STAT signalling components by genome-wide RNA interference","volume":"436","author":"M\u00fcller","year":"2005","journal-title":"Nature"},{"key":"2021042513380100400_DMM028118C47","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/sji.12170","article-title":"JAK\/STAT pathway in Drosophila immunity","volume":"79","author":"Myllym\u00e4ki","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"2021042513380100400_DMM028118C48","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbrc.2013.04.107","article-title":"Upd3 - An ancestor of the four-helix bundle cytokines","volume":"436","author":"Oldefest","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042513380100400_DMM028118C49","doi-asserted-by":"publisher","first-page":"637","DOI":"10.18632\/aging.100054","article-title":"The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila","volume":"1","author":"Park","year":"2009","journal-title":"Aging"},{"key":"2021042513380100400_DMM028118C50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12750\/JET.2015.30.1.1","article-title":"Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program","volume":"30","author":"Park","year":"2015","journal-title":"EMBO J."},{"key":"2021042513380100400_DMM028118C51","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1242\/dmm.000950","article-title":"An innate immune response of blood cells to tumors and tissue damage in Drosophila","volume":"1","author":"Pastor-Pareja","year":"2008","journal-title":"Dis. Model. Mech."},{"key":"2021042513380100400_DMM028118C52","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1182\/blood-2008-10-183558","article-title":"Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor","volume":"115","author":"Pecquet","year":"2010","journal-title":"Blood"},{"key":"2021042513380100400_DMM028118C53","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1242\/dev.125.10.1909","article-title":"A role for the Drosophila Toll\/Cactus pathway in larval hematopoiesis","volume":"125","author":"Qiu","year":"1998","journal-title":"Development"},{"key":"2021042513380100400_DMM028118C54","doi-asserted-by":"publisher","first-page":"13815","DOI":"10.1038\/ncomms13815","article-title":"JAK\/STAT controls organ size and fate specification by regulating morphogen production and signalling","volume":"8","author":"Recasens-Alvarez","year":"2017","journal-title":"Nat. Commun."},{"key":"2021042513380100400_DMM028118C55","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/genetics\/162.3.1259","article-title":"Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene","volume":"162","author":"Remillieux-Leschelle","year":"2002","journal-title":"Genetics"},{"key":"2021042513380100400_DMM028118C56","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/embor.2008.170","article-title":"Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences","volume":"9","author":"Rivas","year":"2008","journal-title":"EMBO Rep."},{"key":"2021042513380100400_DMM028118C57","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1091\/mbc.E04-11-1008","article-title":"Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH2-terminal kinase","volume":"16","author":"Sano","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"2021042513380100400_DMM028118C58","doi-asserted-by":"publisher","first-page":"e1005595","DOI":"10.1371\/journal.pgen.1005595","article-title":"ROS-induced JNK and p38 signaling is required for unpaired cytokine activation during Drosophila regeneration","volume":"11","author":"Santab\u00e1rbara-Ruiz","year":"2015","journal-title":"PLoS Genet."},{"key":"2021042513380100400_DMM028118C59","doi-asserted-by":"publisher","first-page":"e1002168","DOI":"10.1371\/journal.pgen.1002168","article-title":"MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress","volume":"7","author":"Seisenbacher","year":"2011","journal-title":"PLoS Genet."},{"key":"2021042513380100400_DMM028118C60","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.cell.2011.05.029","article-title":"Inheritance of stress-induced, ATF-2-dependent epigenetic change","volume":"145","author":"Seong","year":"2011","journal-title":"Cell"},{"key":"2021042513380100400_DMM028118C61","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1309\/2450EGK3V0XK8D9D","article-title":"p38 mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromes","volume":"130","author":"Shahjahan","year":"2008","journal-title":"Am. J. Clin. Pathol."},{"key":"2021042513380100400_DMM028118C62","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/ncb1713","article-title":"Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability","volume":"10","author":"Shi","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2021042513380100400_DMM028118C63","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/dbio.2001.0542","article-title":"Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated","volume":"243","author":"Sorrentino","year":"2002","journal-title":"Dev. Biol."},{"key":"2021042513380100400_DMM028118C64","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1534\/genetics.166.3.1343","article-title":"Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila","volume":"166","author":"Sorrentino","year":"2004","journal-title":"Genetics"},{"key":"2021042513380100400_DMM028118C65","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1083\/jcb.200405120","article-title":"Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration","volume":"168","author":"Stramer","year":"2005","journal-title":"J. Cell Biol."},{"key":"2021042513380100400_DMM028118C66","doi-asserted-by":"publisher","first-page":"e0130078","DOI":"10.1371\/journal.pone.0130078","article-title":"Methotrexate Is a JAK\/STAT Pathway Inhibitor","volume":"10","author":"Thomas","year":"2015","journal-title":"PLoS ONE"},{"key":"2021042513380100400_DMM028118C67","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1089\/jir.2013.0146","article-title":"The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation","volume":"34","author":"Tiedje","year":"2014","journal-title":"J. Interferon Cytokine Res."},{"key":"2021042513380100400_DMM028118C68","doi-asserted-by":"publisher","first-page":"5232","DOI":"10.1182\/blood-2009-05-223727","article-title":"CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms","volume":"115","author":"Tyner","year":"2010","journal-title":"Blood"},{"key":"2021042513380100400_DMM028118C69","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.devcel.2011.09.002","article-title":"A muscle-specific p38 MAPK\/Mef2\/MnSOD pathway regulates stress, motor function, and life span in Drosophila","volume":"21","author":"Vrailas-Mortimer","year":"2011","journal-title":"Dev. Cell"},{"key":"2021042513380100400_DMM028118C70","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.15252\/embr.201540277","article-title":"JAK\/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection","volume":"16","author":"Yang","year":"2015","journal-title":"EMBO Rep."},{"key":"2021042513380100400_DMM028118C71","doi-asserted-by":"publisher","first-page":"14192","DOI":"10.1073\/pnas.0403789101","article-title":"A directed screen for genes involved in Drosophila blood cell activation","volume":"101","author":"Zettervall","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dmm.028118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/10\/4\/399\/1860670\/dmm028118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.028118\/2069466\/dmm_028118v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.028118\/2069466\/dmm_028118v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T19:57:47Z","timestamp":1658692667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/doi\/10.1242\/dmm.028118\/257050\/Drosophila-model-of-myeloproliferative-neoplasm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":71,"URL":"https:\/\/doi.org\/10.1242\/dmm.028118","relation":{},"ISSN":["1754-8411","1754-8403"],"issn-type":[{"value":"1754-8411","type":"electronic"},{"value":"1754-8403","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"dmm.028118"}}