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Obesity is hypothesised to aid recovery by protecting against post-stroke catabolism. We therefore assessed whether obese mice had an altered metabolic and inflammatory response to stroke. Obese ob\/ob mice underwent 20 min middle cerebral artery occlusion and 24 h reperfusion. Lipid metabolism and expression of inflammatory cytokines were assessed in the plasma, liver and adipose tissue. The obese-specific metabolic response to stroke was assessed in plasma using non-targeted UPLC-MS metabolomics coupled with univariate and multivariate analysis. Obesity had no effect on the extent of weight loss 24 h after stroke but affected the metabolic and inflammatory responses to stroke, predominantly affecting lipid metabolism. Specifically, obese mice had increases in plasma free fatty acids and expression of adipose lipolytic enzymes. Metabolomics identified several classes of metabolites affected by stroke in obese mice, including fatty acids and membrane lipids (glycerophospholipids, lysophospholipids and sphingolipids). Obesity also featured increases in inflammatory cytokines in the plasma and adipose tissue. Overall these results demonstrate that obesity affected the acute metabolic and inflammatory response to stroke and suggest a potential role for adipose tissue in this effect. These findings could have implications for longer-term recovery and also further highlight the importance of considering comorbidities in preclinical stroke research, especially when identifying biomarkers for stroke. However, further work is required to assess whether these changes translate into long-term effects on recovery.<\/jats:p>","DOI":"10.1242\/dmm.030411","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:30:25Z","timestamp":1502411425000},"source":"Crossref","is-referenced-by-count":15,"title":["Adipose tissue, metabolic and inflammatory responses to stroke are altered in obese mice"],"prefix":"10.1242","author":[{"given":"Michael J.","family":"Haley","sequence":"first","affiliation":[{"name":"Faculty of Biological, Medical and Human Sciences, University of Manchester, Manchester, United Kingdom, M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Mullard","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Biological, Medical and Human Sciences, University of Manchester, Manchester, M13 9WL, UK"},{"name":"Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Hollywood","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Biological, Medical and Human Sciences, University of Manchester, Manchester, M13 9WL, UK"},{"name":"Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK"},{"name":"School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth J.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Biological, Medical and Human Sciences, University of Manchester, Manchester, M13 9WL, UK"},{"name":"Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Auckland 1020, New Zealand"},{"name":"Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick B.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Biological, Medical and Human Sciences, University of Manchester, Manchester, M13 9WL, UK"},{"name":"Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK"},{"name":"School of Biosciences and Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-2968","authenticated-orcid":false,"given":"Catherine B.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Faculty of Biological, Medical and Human Sciences, University of Manchester, Manchester, United Kingdom, M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042423594785500_DMM030411C1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1074\/jbc.273.1.215","article-title":"Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro","volume":"273","author":"Anthonsen","year":"1998","journal-title":"J. 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