{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:17:44Z","timestamp":1792516664635,"version":"4.5.0"},"reference-count":115,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":947,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["5RO1AA018886"],"award-info":[{"award-number":["5RO1AA018886"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32 HD049311-09"],"award-info":[{"award-number":["T32 HD049311-09"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES023515"],"award-info":[{"award-number":["P30ES023515"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The rapid increase in fatty liver disease (FLD) incidence is attributed largely to genetic and lifestyle factors; however, environmental toxicants are a frequently overlooked factor that can modify the effects of more common causes of FLD. Chronic exposure to inorganic arsenic (iAs) is associated with liver disease in humans and animal models, but neither the mechanism of action nor the combinatorial interaction with other disease-causing factors has been fully investigated. Here, we examined the contribution of iAs to FLD using zebrafish and tested the interaction with ethanol to cause alcoholic liver disease (ALD). We report that zebrafish exposed to iAs throughout development developed specific phenotypes beginning at 4\u2005days post-fertilization (dpf), including the development of FLD in over 50% of larvae by 5\u2005dpf. Comparative transcriptomic analysis of livers from larvae exposed to either iAs or ethanol revealed the oxidative stress response and the unfolded protein response (UPR) caused by endoplasmic reticulum (ER) stress as common pathways in both these models of FLD, suggesting that they target similar cellular processes. This was confirmed by our finding that arsenic is synthetically lethal with both ethanol and a well-characterized ER-stress-inducing agent (tunicamycin), suggesting that these exposures work together through UPR activation to cause iAs toxicity. Most significantly, combined exposure to sub-toxic concentrations of iAs and ethanol potentiated the expression of UPR-associated genes, cooperated to induce FLD, reduced the expression of as3mt, which encodes an arsenic-metabolizing enzyme, and significantly increased the concentration of iAs in the liver. This demonstrates that iAs exposure is sufficient to cause FLD and that low doses of iAs can potentiate the effects of ethanol to cause liver disease.<\/jats:p><jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/dmm.031575","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T01:20:43Z","timestamp":1514510443000},"source":"Crossref","is-referenced-by-count":62,"title":["Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish"],"prefix":"10.1242","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-973X","authenticated-orcid":false,"given":"Kathryn","family":"Bambino","sequence":"first","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai 1 Department of Environmental Medicine and Public Health , , New York, New York 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi, Saadiyat Island Campus 2 Program in Biology , , PO Box 129188 Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Austin","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai 1 Department of Environmental Medicine and Public Health , , New York, New York 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Amarasiriwardena","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai 1 Department of Environmental Medicine and Public Health , , New York, New York 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Arora","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai 1 Department of Environmental Medicine and Public Health , , New York, New York 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-8630","authenticated-orcid":false,"given":"Jaime","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hepatology, Icahn School of Medicine at Mount Sinai 3 Department of Pediatrics , , New York, New York 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-4125","authenticated-orcid":false,"given":"Kirsten C.","family":"Sadler","sequence":"additional","affiliation":[{"name":"New York University Abu Dhabi, Saadiyat Island Campus 2 Program in Biology , , PO Box 129188 Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"2024061302130115600_DMM031575C1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.annepidem.2007.05.013","article-title":"Nonalcoholic fatty liver disease","volume":"17","author":"Adams","year":"2007","journal-title":"Ann. 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