{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:39:06Z","timestamp":1790721546695,"version":"4.1.0"},"reference-count":33,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81425006"],"award-info":[{"award-number":["81425006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16140900800"],"award-info":[{"award-number":["16140900800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Creative Foundation for Translational Medicine from Shanghai Jiao Tong University School of Medicine","award":["15ZH4005"],"award-info":[{"award-number":["15ZH4005"]}]},{"name":"Program for Eastern Young Scholar at Shanghai Institutions of Higher Learning","award":["QD2016003"],"award-info":[{"award-number":["QD2016003"]}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"crossref","award":["17QA1402800"],"award-info":[{"award-number":["17QA1402800"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Pujiang Program","award":["16PJ1408500"],"award-info":[{"award-number":["16PJ1408500"]}]},{"name":"Chenxing Project from Shanghai Jiao Tong University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Subretinal fibrosis results in local destruction of retinal structures and permanent vision loss, representing the end stage of neovascular age-related macular degeneration (AMD). Histological examination of fibrotic specimens from AMD patients has uncovered a wide range of cellular and acellular components. However, their origins and roles in fibrosis remain largely unexplored. Using laser-induced photocoagulation model with Collagen 1\u03b11-GFP reporter mice, we demonstrate by cell-lineage tracing that a subset of pericytes associating with choroidal microvasculature are activated upon injury and infiltrate into subretinal space as significant components of fibrotic lesions. In contrast to their choroidal precursors, infiltrating pericytes acquire stellate-like structures, upregulate expression of fibrogenic molecules and colocalize with extracellular fibrotic scar. Collectively, our results identify choroidal perivascular niche as a novel source of subretinal fibrosis after photocoagulation and suggest that collagen 1-expressing pericytes are potential targets for therapeutic intervention to suppress subretinal fibrosis and preserve vision.<\/jats:p>","DOI":"10.1242\/dmm.032060","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T12:20:13Z","timestamp":1522844413000},"source":"Crossref","is-referenced-by-count":27,"title":["Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-1419","authenticated-orcid":false,"given":"Xueting","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai 200080, China"},{"name":"Shanghai Key Laboratory of Fundus 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