{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:04:24Z","timestamp":1772168664421,"version":"3.50.1"},"reference-count":68,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100009024","name":"Exploratory Research for Advanced Technology","doi-asserted-by":"publisher","award":["JPMJER1303"],"award-info":[{"award-number":["JPMJER1303"]}],"id":[{"id":"10.13039\/501100009024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"crossref","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP15H02370"],"award-info":[{"award-number":["JP15H02370"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The nature of host organs and genes that underlie tumor-induced physiological disruption on host remains ill-defined. Here, we establish a novel zebrafish intestinal tumor model that is suitable for addressing this issue, and find that hepatic cyp7a1, the rate-limiting factor for synthesizing bile acids, in the case of zebrafish bile alcohol (BA), is such a host gene. Inducing krasG12D by Gal4 specifically expressed in the posterior intestine resulted in formation of intestinal tumor. The local intestinal tumor caused systemic detrimental effects on host including liver inflammation, hepatomegaly, growth defects, and organismal death. Whole-organismal level gene expression analysis and metabolite measurements revealed that the intestinal tumor reduced total BA levels possibly via altered expression of hepatic cyp7a1. Genetically overexpressing cyp7a1 in the liver restored the BA synthesis and ameliorated tumor-induced liver inflammation, but not other tumor-dependent phenotypes. Thus, we found a previously unknown role of cyp7a1 as the host gene that links the intestinal tumor, hepatic cholesterol-BA metabolism, and liver inflammation in tumor-bearing zebrafish larvae. Our model provides an important basis to discover host genes responsible for tumor-induced phenotypes and to uncover mechanisms underlying how tumors adversely affect host organisms.<\/jats:p>","DOI":"10.1242\/dmm.032383","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T10:25:26Z","timestamp":1522232726000},"source":"Crossref","is-referenced-by-count":28,"title":["A novel zebrafish intestinal tumor model reveals a role for\n                    <i>cyp7a1<\/i>\n                    -dependent tumor-liver crosstalk in tumor's adverse effects on host"],"prefix":"10.1242","author":[{"given":"Sora","family":"Enya","sequence":"first","affiliation":[{"name":"Advanced Telecommunications Research Institute International (ATR), The Thomas N. Sato BioMEC-X Laboratories, Kyoto, Japan"},{"name":"ERATO Sato Live Bio-forecasting Project, Japan Science and Technology Agency (JST), Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-1435","authenticated-orcid":false,"given":"Koichi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Molecular and Developmental Biology, National Institute of Genetics, and Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Mishima, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"The University of Tokyo, graduate school of frontier science, Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-6781","authenticated-orcid":false,"given":"Shinpei","family":"Kawaoka","sequence":"additional","affiliation":[{"name":"Advanced Telecommunications Research Institute International (ATR), The Thomas N. 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