{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:11:31Z","timestamp":1788883891479,"version":"build-2803163510"},"reference-count":58,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":947,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/501100003406","name":"Tekes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009960","name":"Pirkanmaa Hospital District","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009960","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disease that affects the heart muscle with diverse clinical outcomes. HCM can cause sudden cardiac death (SCD) during or immediately after mild to rigorous physical activity in young patients. However, the mechanism causing SCD as a result of exercise remains unknown, but exercise-induced ventricular arrhythmias are thought to be responsible for this fatal consequence. To understand the disease mechanism behind HCM in a better way, we generated patient-specific induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from HCM patients carrying either the MYBPC3-Gln1061X or TPM1-Asp175Asn mutation. We extensively investigated the effects of low to high concentrations of adrenaline on action potential characteristics, and the occurrence of arrhythmias in the presence of various concentrations of adrenaline and in wash-out condition. We classified and quantified different types of arrhythmias observed in hiPSC-CMs, and found that the occurrence of arrhythmias was dependent on concentrations of adrenaline and positions of mutations in genes causing HCM. In addition, we observed ventricular tachycardia types of arrhythmias in hiPSC-CMs carrying the TPM1-Asp175Asn mutation. We additionally examined the antiarrhythmic potency of bisoprolol in HCM-specific hiPSC-CMs. However, bisoprolol could not reduce the occurrence of arrhythmias during administration or during the wash-out condition of adrenaline in HCM-specific hiPSC-CMs. Our study demonstrates hiPSC-CMs as a promising tool for studying HCM. The experimental design used in this study could be suitable and beneficial for studying other components and drugs related to cardiac disease in general.<\/jats:p>","DOI":"10.1242\/dmm.032896","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T01:20:19Z","timestamp":1519694419000},"source":"Crossref","is-referenced-by-count":23,"title":["Divergent effects of adrenaline in human induced pluripotent stem cell-derived cardiomyocytes obtained from hypertrophic cardiomyopathy"],"prefix":"10.1242","volume":"11","author":[{"given":"Chandra","family":"Prajapati","sequence":"first","affiliation":[{"name":"University of Tampere 1 BioMediTech , , 33014 Tampere , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-2153","authenticated-orcid":false,"given":"Marisa","family":"Ojala","sequence":"additional","affiliation":[{"name":"University of Tampere 1 BioMediTech , , 33014 Tampere , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-2172","authenticated-orcid":false,"given":"Katriina","family":"Aalto-Set\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"University of Tampere 1 BioMediTech , , 33014 Tampere , Finland"},{"name":"University of Tampere 2 Faculty of Medicine and Life Science , , 33014 Tampere , Finland"},{"name":"Heart Hospital, Tampere University Hospital 3 , 33521 Tampere , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"2024061302112898000_DMM032896C1","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.jacc.2004.11.043","article-title":"Spectrum and prognostic significance of arrhythmias on ambulatory Holter electrocardiogram in hypertrophic cardiomyopathy","volume":"45","author":"Adabag","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024061302112898000_DMM032896C2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.ahj.2005.06.016","article-title":"Heart rate variability in patients with cardiac hypertrophy\u2014Relation to left ventricular mass and etiology","volume":"151","author":"Alter","year":"2006","journal-title":"Am. Heart J."},{"key":"2024061302112898000_DMM032896C3","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1056\/NEJM199711273372202","article-title":"A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias","volume":"337","author":"Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2024061302112898000_DMM032896C4","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1111\/pace.12227","article-title":"Electrophysiologic characteristics and pharmacologic response of human cardiomyocytes isolated from a patient with hypertrophic cardiomyopathy","volume":"36","author":"Barajas-Mart\u00ednez","year":"2013","journal-title":"Pacing Clin. Electrophysiol."},{"key":"2024061302112898000_DMM032896C5","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1038\/sj.bjp.0704188","article-title":"Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium","volume":"133","author":"Brixius","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"2024061302112898000_DMM032896C6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0031-6997(24)01425-X","article-title":"Adrenergic and muscarinic receptors in the human heart","volume":"51","author":"Brodde","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"2024061302112898000_DMM032896C7","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1161\/01.CIR.0000065578.00869.7C","article-title":"Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity","volume":"107","author":"Burashnikov","year":"2003","journal-title":"Circulation"},{"key":"2024061302112898000_DMM032896C8","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1016\/j.bpj.2012.05.011","article-title":"Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers","volume":"102","author":"Chang","year":"2012","journal-title":"Biophys. J."},{"key":"2024061302112898000_DMM032896C9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1136\/hrt.75.1.50","article-title":"Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy","volume":"75","author":"Choudhury","year":"1996","journal-title":"Heart"},{"key":"2024061302112898000_DMM032896C10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.112.134932","article-title":"Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy","volume":"127","author":"Coppini","year":"2013","journal-title":"Circulation"},{"key":"2024061302112898000_DMM032896C11","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1161\/01.CIR.88.4.1682","article-title":"Assessment of heart rate variability in hypertrophic cardiomyopathy. Association with clinical and prognostic features","volume":"88","author":"Counihan","year":"1993","journal-title":"Circulation"},{"key":"2024061302112898000_DMM032896C12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0735-1097(96)00538-4","article-title":"Clinical features of hypertrophic cardiomyopathy caused by mutation of a \u201cHot Spot\u201d in the Alpha-Tropomyosin gene","volume":"29","author":"Coviello","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024061302112898000_DMM032896C13","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1067\/mhj.2002.121269","article-title":"Effects of bisoprolol fumarate on left ventricular size, function, and exercise capacity in patients with heart failure: analysis with magnetic resonance myocardial tagging","volume":"143","author":"Dubach","year":"2002","journal-title":"Am. Heart J."},{"key":"2024061302112898000_DMM032896C14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1113\/jphysiol.1991.sp018516","article-title":"The transient K+ current in rat ventricular myocytes: evaluation of its Ca2+ and Na+ dependence","volume":"435","author":"Dukes","year":"1991","journal-title":"J. Physiol."},{"key":"2024061302112898000_DMM032896C15","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC)","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur. Heart J."},{"key":"2024061302112898000_DMM032896C16","doi-asserted-by":"publisher","first-page":"e83005","DOI":"10.1371\/journal.pone.0083005","article-title":"The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients","volume":"8","author":"Fatima","year":"2013","journal-title":"PLoS ONE"},{"key":"2024061302112898000_DMM032896C17","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1093\/eurheartj\/ehp327","article-title":"Exercise-induced ventricular arrhythmias and risk of sudden cardiac death in patients with hypertrophic cardiomyopathy","volume":"30","author":"Gimeno","year":"2009","journal-title":"Eur. Heart J."},{"key":"2024061302112898000_DMM032896C18","doi-asserted-by":"publisher","first-page":"H1078","DOI":"10.1152\/ajpheart.1997.272.3.H1078","article-title":"Modulation of electrical heterogeneity by compensated hypertrophy in rat left ventricle","volume":"272","author":"Gomez","year":"1997","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024061302112898000_DMM032896C19","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/cvr\/cvu205","article-title":"Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells","volume":"104","author":"Han","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"2024061302112898000_DMM032896C20","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.yjmcc.2003.10.003","article-title":"Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene","volume":"36","author":"Hedman","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2024061302112898000_DMM032896C21","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1590\/S0066-782X2007000300014","article-title":"Effects of bisoprolol on cardiac function and exercise in patients with heart failure","volume":"88","author":"Issa","year":"2007","journal-title":"Arq. Bras. Cardiol."},{"key":"2024061302112898000_DMM032896C22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s00109-002-0323-9","article-title":"Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland","volume":"80","author":"J\u00e4\u00e4skel\u00e4inen","year":"2002","journal-title":"J. Mol. Med."},{"key":"2024061302112898000_DMM032896C23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3109\/07853890.2012.671534","article-title":"Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population","volume":"45","author":"J\u00e4\u00e4skel\u00e4inen","year":"2013","journal-title":"Ann. Med."},{"key":"2024061302112898000_DMM032896C24","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1476-5381.1988.tb11564.x","article-title":"Adrenoceptor-mediated changes of action potential and force of contraction in human isolated ventricular heart muscle","volume":"94","author":"Jakob","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"2024061302112898000_DMM032896C25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0031-6997(25)00019-5","article-title":"Delayed afterdepolarizations in heart muscle: mechanisms and relevance","volume":"40","author":"January","year":"1988","journal-title":"Pharmacol. Rev."},{"key":"2024061302112898000_DMM032896C26","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s11936-014-0320-7","article-title":"hiPSC modeling of inherited cardiomyopathies","volume":"16","author":"Jung","year":"2014","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"2024061302112898000_DMM032896C27","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1161\/01.RES.0000059562.91384.1A","article-title":"Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling","volume":"92","author":"Knollmann","year":"2003","journal-title":"Circ. Res."},{"key":"2024061302112898000_DMM032896C28","doi-asserted-by":"publisher","first-page":"e44660","DOI":"10.1371\/journal.pone.0044660","article-title":"Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations","volume":"7","author":"Kujala","year":"2012","journal-title":"PLoS ONE"},{"key":"2024061302112898000_DMM032896C29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1242\/dmm.008409","article-title":"Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture","volume":"5","author":"Lahti","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"2024061302112898000_DMM032896C30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.stem.2012.10.010","article-title":"Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells","volume":"12","author":"Lan","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2024061302112898000_DMM032896C31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13287-015-0027-z","article-title":"Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes","volume":"6","author":"Ma","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"2024061302112898000_DMM032896C32","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.111.045146","article-title":"Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior","volume":"125","author":"Mandel","year":"2012","journal-title":"Circulation"},{"key":"2024061302112898000_DMM032896C33","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume-title":"Lancet","author":"Maron","year":"2013"},{"key":"2024061302112898000_DMM032896C34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1161\/CIRCGENETICS.114.000741","article-title":"The 25-year genetic era in hypertrophic cardiomyopathy: revisited","volume":"7","author":"Maron","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"2024061302112898000_DMM032896C35","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1056\/NEJM200002103420601","article-title":"Efficacy of implantable cardioverter\u2013defibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy","volume":"342","author":"Maron","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"2024061302112898000_DMM032896C36","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1161\/CIRCEP.110.959064","article-title":"Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome","volume":"4","author":"Maruyama","year":"2011","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"2024061302112898000_DMM032896C37","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/S0735-1097(03)00827-1","article-title":"Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy","volume":"42","author":"Monserrat","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"2024061302112898000_DMM032896C38","doi-asserted-by":"publisher","first-page":"H1023","DOI":"10.1152\/ajpheart.00785.2011","article-title":"Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species","volume":"302","author":"O'Hara","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024061302112898000_DMM032896C39","doi-asserted-by":"publisher","first-page":"1684792","DOI":"10.1155\/2016\/1684792","article-title":"Mutation-specific phenotypes in hiPSC-derived cardiomyocytes carrying either myosin-binding protein C or alpha-tropomyosin mutation for hypertrophic cardiomyopathy","volume":"2016","author":"Ojala","year":"2016","journal-title":"Stem Cells Int."},{"key":"2024061302112898000_DMM032896C40","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/j.1440-1681.1998.tb02177.x","article-title":"Augmented exercise plasma noradrenaline with impaired chronotropic responsiveness in patients with hypertrophic cardiomyopathy","volume":"25","author":"Omodani","year":"1998","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2024061302112898000_DMM032896C41","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1139\/cjpp-2014-0526","article-title":"Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy","volume":"93","author":"Orosz","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024061302112898000_DMM032896C42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.yjmcc.2015.09.003","article-title":"Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy","volume":"96","author":"Passini","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2024061302112898000_DMM032896C43","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.amjcard.2013.11.062","article-title":"Heart rate recovery in patients with hypertrophic cardiomyopathy","volume":"113","author":"Patel","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"2024061302112898000_DMM032896C44","doi-asserted-by":"publisher","first-page":"e0125366","DOI":"10.1371\/journal.pone.0125366","article-title":"Antiarrhythmic effects of Dantrolene in patients with Catecholaminergic polymorphic ventricular tachycardia and replication of the responses using iPSC models","volume":"10","author":"Penttinen","year":"2015","journal-title":"PLoS ONE"},{"key":"2024061302112898000_DMM032896C45","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/S0002-9149(97)89316-2","article-title":"Effects of bisoprolol on heart rate variability in heart failure","volume":"77","author":"Pousset","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"2024061302112898000_DMM032896C46","doi-asserted-by":"publisher","first-page":"H1796","DOI":"10.1152\/ajpheart.1990.258.6.H1796","article-title":"Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines","volume":"258","author":"Priori","year":"1990","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2024061302112898000_DMM032896C47","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/BF00169081","article-title":"Hypertrophic cardiomyopathy: a desensitized cardiac \\-adrenergic system in the presence of normal plasma catecholamine concentrations","volume":"351","author":"Schumacher","year":"1995","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"2024061302112898000_DMM032896C48","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1016\/j.bpj.2015.03.011","article-title":"Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes","volume":"108","author":"Song","year":"2015","journal-title":"Biophys. J."},{"key":"2024061302112898000_DMM032896C49","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1093\/eurheartj\/ehs150","article-title":"Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence","volume":"33","author":"Spoladore","year":"2012","journal-title":"Eur. Heart J."},{"key":"2024061302112898000_DMM032896C50","doi-asserted-by":"publisher","first-page":"R1463","DOI":"10.1152\/ajpregu.90583.2008","article-title":"Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death","volume":"295","author":"Sridhar","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2024061302112898000_DMM032896C51","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"2024061302112898000_DMM032896C52","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0008-6363(99)00017-6","article-title":"Electrophysiological remodeling in hypertrophy and heart failure","volume":"42","author":"Tomaselli","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"2024061302112898000_DMM032896C53","doi-asserted-by":"publisher","first-page":"188","DOI":"10.15420\/aer.2016:30:2","article-title":"ICD therapy for primary prevention in hypertrophic cardiomyopathy","volume":"5","author":"Trivedi","year":"2016","journal-title":"Arrhythm. Electrophysiol. Rev."},{"key":"2024061302112898000_DMM032896C54","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s12471-011-0090-8","article-title":"Exercise related ventricular arrhythmias are related to cardiac fibrosis in hypertrophic cardiomyopathy mutation carriers","volume":"19","author":"van Rijsingen","year":"2011","journal-title":"Neth. Heart J."},{"key":"2024061302112898000_DMM032896C55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1476-5381.2011.01367.x","article-title":"Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk","volume":"164","author":"Varr\u00f3","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"2024061302112898000_DMM032896C56","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/cs0660087","article-title":"Adrenaline secretion during exercise","volume":"66","author":"Warren","year":"1984","journal-title":"Clin. Sci."},{"key":"2024061302112898000_DMM032896C57","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/europace\/eut412","article-title":"How does beta-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?","volume":"16","author":"Xie","year":"2014","journal-title":"Europace"},{"key":"2024061302112898000_DMM032896C58","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.pbiomolbio.2017.06.015","article-title":"Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy","volume":"130","author":"Zile","year":"2017","journal-title":"Prog. Biophys. Mol. Biol."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dmm.032896","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.032896\/3483078\/dmm032896.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.032896\/2070218\/dmm_032896v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.032896\/3483078\/dmm032896.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T01:15:10Z","timestamp":1751418910000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/11\/2\/dmm032896\/53194\/Divergent-effects-of-adrenaline-in-human-induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.032896","relation":{},"ISSN":["1754-8411","1754-8403"],"issn-type":[{"value":"1754-8411","type":"electronic"},{"value":"1754-8403","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2,1]]},"article-number":"dmm032896"}}