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Most BWS cases are linked to loss of methylation at the imprint control region 2 (ICR2) within this domain, which in mice regulates the silencing of several maternally expressed imprinted genes. Modelling this disorder in mice is confounded by the unique embryonic requirement for Ascl2, which is imprinted in mice but not in humans. To overcome this issue, we generated a novel model combining a truncation of distal chromosome 7 allele (DelTel7) with transgenic rescue of Ascl2 expression. This novel model recapitulated placentomegaly associated with BWS, but did not lead to fetal overgrowth.<\/jats:p>","DOI":"10.1242\/dmm.035832","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T12:11:57Z","timestamp":1535544717000},"source":"Crossref","is-referenced-by-count":6,"title":["Fetal growth restriction in a genetic model of sporadic Beckwith\u2013Wiedemann syndrome"],"prefix":"10.1242","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-9452","authenticated-orcid":false,"given":"Simon J.","family":"Tunster","sequence":"first","affiliation":[{"name":"Cardiff School of Biosciences, Cardiff University 1 , Cardiff CF10 3AX , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Van de Pette","sequence":"additional","affiliation":[{"name":"Cardiff School of Biosciences, Cardiff University 1 , Cardiff CF10 3AX , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo D. 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