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Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable descending neurons. Pharmacological and genetic manipulations after a complete spinal cord injury showed that endogenous serotonin inhibits axonal regeneration in identifiable descending neurons through the activation of serotonin 1A receptors and a subsequent decrease in cAMP levels. RNA sequencing revealed that changes in the expression of genes that control axonal guidance could be a key factor on the serotonin effects during regeneration. This study provides new targets of interest for research in non-regenerating mammalian models of traumatic CNS injuries and extends the known roles of serotonin signalling during neuronal regeneration.<\/jats:p>","DOI":"10.1242\/dmm.037085","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T09:29:14Z","timestamp":1549013354000},"source":"Crossref","is-referenced-by-count":14,"title":["Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys"],"prefix":"10.1242","author":[{"given":"Daniel","family":"Sobrido-Came\u00e1n","sequence":"first","affiliation":[{"name":"Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Robledo","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, EH25 9RG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Santiago de Compostela, Campus de Lugo, Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Celina","family":"Rodicio","sequence":"additional","affiliation":[{"name":"Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-080X","authenticated-orcid":false,"given":"Ant\u00f3n","family":"Barreiro-Iglesias","sequence":"additional","affiliation":[{"name":"Department of Functional Biology, CIBUS, Faculty of Biology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"2021042513043661700_DMM037085C1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jchemneu.2007.03.010","article-title":"Development of the serotonergic system in the central nervous system of the sea lamprey","volume":"34","author":"Abalo","year":"2007","journal-title":"J. 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