{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:22:14Z","timestamp":1791872534929,"version":"4.3.4"},"reference-count":51,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":557,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRA_POR\/2013\/348"],"award-info":[{"award-number":["HRA_POR\/2013\/348"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004200","name":"Stiftelsen Olle Engkvist Byggm\u00e4stare","doi-asserted-by":"publisher","award":["SLS-499431"],"award-info":[{"award-number":["SLS-499431"]}],"id":[{"id":"10.13039\/501100004200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008084","name":"Neurof\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["16\/RC\/3948"],"award-info":[{"award-number":["16\/RC\/3948"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ulla-Carin Lindquists Foundation"},{"DOI":"10.13039\/501100005701","name":"\u00c5hlen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005701","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Amyotrophic lateral sclerosis (ALS) presents a poorly understood pathogenesis. Evidence from patients and mutant SOD1 mouse models suggests vascular damage may precede or aggravate motor dysfunction in ALS. We have previously shown angiogenin (ANG) treatment enhances motor neuron survival, delays motor dysfunction and prevents vascular regression in the SOD1G93A ALS model. However, the existence of vascular defects at different stages of disease progression remains to be established in other ALS models. Here, we assessed vascular integrity in vivo throughout different disease stages, and investigated whether ANG treatment reverses vascular regression and prolongs motor neuron survival in the FUS (1-359) mouse model of ALS. Lumbar spinal cord tissue was collected from FUS (1-359) and non-transgenic control mice at postnatal day (P)50, P90 and P120. We found a significant decrease in vascular network density in lumbar spinal cords from FUS (1-359) mice by day 90, at which point motor neuron numbers were unaffected. ANG treatment did not affect survival or counter vascular regression. Endogenous Ang1 and Vegf expression were unchanged at P50 and P90; however, we found a significant decrease in miRNA 126 at P50, indicating vascular integrity in FUS mice may be compromised via an alternative pathway. Our study demonstrates that vascular regression occurs before motor neuron degeneration in FUS (1-359) mice, and highlights that heterogeneity in responses to novel ALS therapeutics can already be detected in preclinical mouse models of ALS.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the joint first authors of the paper.<\/jats:p>","DOI":"10.1242\/dmm.040238","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T15:45:13Z","timestamp":1565019913000},"source":"Crossref","is-referenced-by-count":18,"title":["Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model"],"prefix":"10.1242","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9535-7595","authenticated-orcid":false,"given":"Martin","family":"Crivello","sequence":"first","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2815-8761","authenticated-orcid":false,"given":"Marion C.","family":"Hogg","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"},{"name":"FutureNeuro Research Centre, Royal College of Surgeons in Ireland 2 , St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Jirstr\u00f6m","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"},{"name":"FutureNeuro Research Centre, Royal College of Surgeons in Ireland 2 , St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Halang","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Woods","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Rayner","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian A.","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Karolinska Institute 3 Tissue Biology Laboratory, Department of Clinical Neuroscience , , Karolinska v\u00e4gen 8A, 17164, Stockholm , Sweden"},{"name":"4 Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH-Royal Institute of Technology, Tomteboda v\u00e4gen 23 A, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3479-7794","authenticated-orcid":false,"given":"Jochen H. M.","family":"Prehn","sequence":"additional","affiliation":[{"name":"Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland 1 Department of Physiology and Medical Physics , , 123 St. Stephen's Green, Dublin 2 , Ireland"},{"name":"FutureNeuro Research Centre, Royal College of Surgeons in Ireland 2 , St. Stephen's Green, Dublin 2 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"2024061302252817500_DMM040238C1","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1006\/dbio.1996.0074","article-title":"A nuclear protein regulated during the transition from active to quiescent phenotype in cultured endothelial cells","volume":"174","author":"Alliegro","year":"1996","journal-title":"Dev. Biol."},{"key":"2024061302252817500_DMM040238C2","doi-asserted-by":"publisher","first-page":"19037","DOI":"10.1074\/jbc.M200737200","article-title":"Nuclear injection of anti-pigpen antibodies inhibits endothelial cell division","volume":"277","author":"Alliegro","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2024061302252817500_DMM040238C3","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1471-2121-9-37","article-title":"The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response","volume":"9","author":"Andersson","year":"2008","journal-title":"BMC Cell Biol."},{"key":"2024061302252817500_DMM040238C4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1474-4422(17)30401-5","article-title":"Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications","volume":"17","author":"Chia","year":"2018","journal-title":"Lancet Neurol."},{"key":"2024061302252817500_DMM040238C5","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3109\/17482960802566824","article-title":"Prognostic factors in ALS: a critical review","volume":"10","author":"Chio","year":"2009","journal-title":"Amyotroph Lateral Scler."},{"key":"2024061302252817500_DMM040238C6","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.neurobiolaging.2014.09.022","article-title":"\u201cPreconditioning\u201d with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice","volume":"36","author":"Coughlan","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"2024061302252817500_DMM040238C7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.neuropharm.2018.02.022","article-title":"Pleiotropic activity of systemically delivered angiogenin in the SOD1(G93A) mouse model","volume":"133","author":"Crivello","year":"2018","journal-title":"Neuropharmacology"},{"key":"2024061302252817500_DMM040238C8","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1093\/brain\/awx248","article-title":"Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in \u2018FUSDelta14\u2019 knockin mice","volume":"140","author":"Devoy","year":"2017","journal-title":"Brain"},{"key":"2024061302252817500_DMM040238C9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.mcn.2013.03.006","article-title":"Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration","volume":"56","author":"Dormann","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"2024061302252817500_DMM040238C10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","article-title":"miR-126 regulates angiogenic signaling and vascular integrity","volume":"15","author":"Fish","year":"2008","journal-title":"Dev. Cell"},{"key":"2024061302252817500_DMM040238C11","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1038\/srep02388","article-title":"FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS\/FTLD","volume":"3","author":"Fujioka","year":"2013","journal-title":"Sci. Rep."},{"key":"2024061302252817500_DMM040238C12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.brainres.2011.04.049","article-title":"Amyotrophic lateral sclerosis: a neurovascular disease","volume":"1398","author":"Garbuzova-Davis","year":"2011","journal-title":"Brain Res."},{"key":"2024061302252817500_DMM040238C13","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ng1742","article-title":"ANG mutations segregate with familial and \u2018sporadic\u2019 amyotrophic lateral sclerosis","volume":"38","author":"Greenway","year":"2006","journal-title":"Nat. Genet."},{"key":"2024061302252817500_DMM040238C14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1001\/archneurol.2010.52","article-title":"Novel FUS\/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis","volume":"67","author":"Hewitt","year":"2010","journal-title":"Arch. Neurol."},{"key":"2024061302252817500_DMM040238C15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1080\/21678421.2017.1407796","article-title":"Riluzole does not improve lifespan or motor function in three ALS mouse models","volume":"19","author":"Hogg","year":"2018","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"2024061302252817500_DMM040238C16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1586\/erm.10.103","article-title":"miRNAs: roles and clinical applications in vascular disease","volume":"11","author":"Jamaluddin","year":"2011","journal-title":"Expert Rev. Mol. Diagn."},{"key":"2024061302252817500_DMM040238C17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.pharmthera.2013.10.009","article-title":"Gene and protein therapies utilizing VEGF for ALS","volume":"141","author":"Keifer","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"2024061302252817500_DMM040238C18","doi-asserted-by":"publisher","first-page":"14056","DOI":"10.1523\/JNEUROSCI.3399-08.2008","article-title":"Control of motoneuron survival by angiogenin","volume":"28","author":"Kieran","year":"2008","journal-title":"J. Neurosci."},{"key":"2024061302252817500_DMM040238C19","doi-asserted-by":"publisher","first-page":"R46","DOI":"10.1093\/hmg\/ddq137","article-title":"TDP-43 and FUS\/TLS: emerging roles in RNA processing and neurodegeneration","volume":"19","author":"Lagier-Tourenne","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2024061302252817500_DMM040238C20","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/nn.3230","article-title":"Divergent roles of ALS-linked proteins FUS\/TLS and TDP-43 intersect in processing long pre-mRNAs","volume":"15","author":"Lagier-Tourenne","year":"2012","journal-title":"Nat. Neurosci."},{"key":"2024061302252817500_DMM040238C21","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00401-015-1520-2","article-title":"Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration","volume":"131","author":"Lewandowski","year":"2016","journal-title":"Acta Neuropathol."},{"key":"2024061302252817500_DMM040238C22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2024061302252817500_DMM040238C23","doi-asserted-by":"publisher","first-page":"7929","DOI":"10.1523\/JNEUROSCI.1877-07.2007","article-title":"Mutant Cu\/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression","volume":"27","author":"Lu","year":"2007","journal-title":"J. Neurosci."},{"key":"2024061302252817500_DMM040238C24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3109\/17482960903545334","article-title":"Guidelines for preclinical animal research in ALS\/MND: A consensus meeting","volume":"11","author":"Ludolph","year":"2010","journal-title":"Amyotroph Lateral Scler."},{"key":"2024061302252817500_DMM040238C25","doi-asserted-by":"publisher","first-page":"5478","DOI":"10.1523\/JNEUROSCI.3037-17.2018","article-title":"miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS","volume":"38","author":"Maimon","year":"2018","journal-title":"J. Neurosci."},{"key":"2024061302252817500_DMM040238C26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s40478-016-0358-8","article-title":"Pathogenesis of FUS-associated ALS and FTD: insights from rodent models","volume":"4","author":"Nolan","year":"2016","journal-title":"Acta Neuropathol Commun."},{"key":"2024061302252817500_DMM040238C27","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fnagi.2017.00068","article-title":"ALS clinical trials review: 20 years of failure. are we any closer to registering a new treatment?","volume":"9","author":"Petrov","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"2024061302252817500_DMM040238C28","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s40478-016-0340-5","article-title":"From animal models to human disease: a genetic approach for personalized medicine in ALS","volume":"4","author":"Picher-Martel","year":"2016","journal-title":"Acta Neuropathol Commun."},{"key":"2024061302252817500_DMM040238C29","doi-asserted-by":"publisher","first-page":"947513","DOI":"10.1155\/2014\/947513","article-title":"Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis","volume":"2014","author":"Pronto-Laborinho","year":"2014","journal-title":"Biomed Res Int."},{"key":"2024061302252817500_DMM040238C30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/ana.24096","article-title":"Long-term survival in amyotrophic lateral sclerosis: a population-based study","volume":"75","author":"Pupillo","year":"2014","journal-title":"Ann. Neurol."},{"key":"2024061302252817500_DMM040238C31","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/mus.21665","article-title":"Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"42","author":"Rademakers","year":"2010","journal-title":"Muscle Nerve."},{"key":"2024061302252817500_DMM040238C32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3109\/21678421.2013.778548","article-title":"Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis","volume":"14","author":"Ravits","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"2024061302252817500_DMM040238C33","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nrn3430","article-title":"The changing scene of amyotrophic lateral sclerosis","volume":"14","author":"Robberecht","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"2024061302252817500_DMM040238C34","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.cell.2017.10.011","article-title":"Edaravone: a new drug approved for ALS","volume":"171","author":"Rothstein","year":"2017","journal-title":"Cell"},{"key":"2024061302252817500_DMM040238C35","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1212\/WNL.0b013e3181d3e2dd","article-title":"Gray matter perfusion correlates with disease severity in ALS","volume":"74","author":"Rule","year":"2010","journal-title":"Neurology"},{"key":"2024061302252817500_DMM040238C36","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00401-017-1687-9","article-title":"Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis","volume":"133","author":"Scekic-Zahirovic","year":"2017","journal-title":"Acta Neuropathol."},{"key":"2024061302252817500_DMM040238C37","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nm.3487","article-title":"MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1","volume":"20","author":"Schober","year":"2014","journal-title":"Nat. Med."},{"key":"2024061302252817500_DMM040238C38","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/cdd.2009.52","article-title":"Angiogenin protects motoneurons against hypoxic injury","volume":"16","author":"Sebastia","year":"2009","journal-title":"Cell Death Differ."},{"key":"2024061302252817500_DMM040238C39","doi-asserted-by":"publisher","first-page":"25266","DOI":"10.1074\/jbc.M113.492017","article-title":"Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice","volume":"288","author":"Shelkovnikova","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2024061302252817500_DMM040238C40","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"key":"2024061302252817500_DMM040238C41","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-brain barrier: from physiology to disease and back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"2024061302252817500_DMM040238C42","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S1474-4422(13)70036-X","article-title":"Controversies and priorities in amyotrophic lateral sclerosis","volume":"12","author":"Turner","year":"2013","journal-title":"Lancet Neurol."},{"key":"2024061302252817500_DMM040238C43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1212\/01.wnl.0000339487.84908.00","article-title":"A case of ALS-FTD in a large FALS pedigree with a K17I ANG mutation","volume":"72","author":"Van Es","year":"2009","journal-title":"Neurology"},{"key":"2024061302252817500_DMM040238C44","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev. Cell"},{"key":"2024061302252817500_DMM040238C45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00401-012-1039-8","article-title":"Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis","volume":"125","author":"Winkler","year":"2013","journal-title":"Acta Neuropathol."},{"key":"2024061302252817500_DMM040238C46","doi-asserted-by":"publisher","first-page":"E1035","DOI":"10.1073\/pnas.1401595111","article-title":"Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice","volume":"111","author":"Winkler","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2024061302252817500_DMM040238C47","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/ana.21221","article-title":"Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis","volume":"62","author":"Wu","year":"2007","journal-title":"Ann. Neurol."},{"key":"2024061302252817500_DMM040238C48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1083\/jcb.200811106","article-title":"Angiogenin cleaves tRNA and promotes stress-induced translational repression","volume":"185","author":"Yamasaki","year":"2009","journal-title":"J. Cell Biol."},{"key":"2024061302252817500_DMM040238C49","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/j.1349-7006.2010.01494.x","article-title":"Pigpen, a nuclear coiled body component protein, is involved in angiogenesis","volume":"101","author":"Yoshida","year":"2010","journal-title":"Cancer Sci."},{"key":"2024061302252817500_DMM040238C50","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.molcel.2018.02.001","article-title":"FUS regulates activity of microRNA-mediated gene silencing","volume":"69","author":"Zhang","year":"2018","journal-title":"Mol. Cell"},{"key":"2024061302252817500_DMM040238C51","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/nn2073","article-title":"ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration","volume":"11","author":"Zhong","year":"2008","journal-title":"Nat. Neurosci."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dmm.040238","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.040238\/3483931\/dmm040238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.040238\/2065547\/dmm_040238v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.040238\/3483931\/dmm040238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T02:25:46Z","timestamp":1718245546000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/12\/8\/dmm040238\/223347\/Vascular-regression-precedes-motor-neuron-loss-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.040238","relation":{},"ISSN":["1754-8411","1754-8403"],"issn-type":[{"value":"1754-8411","type":"electronic"},{"value":"1754-8403","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,1]]},"article-number":"dmm040238"}}