{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:35:02Z","timestamp":1790789702864,"version":"4.1.0"},"reference-count":122,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Muscular dystrophies (MDs) encompass a wide variety of inherited disorders that are characterized by loss of muscle tissue associated with a progressive reduction in muscle function. With a cure lacking for MDs, preclinical developments of therapeutic approaches depend on well-characterized animal models that recapitulate the specific pathology in patients. The mouse is the most widely and extensively used model for MDs, and it has played a key role in our understanding of the molecular mechanisms underlying MD pathogenesis. This has enabled the development of therapeutic strategies. Owing to advancements in genetic engineering, a wide variety of mouse models are available for the majority of MDs. Here, we summarize the characteristics of the most commonly used mouse models for a subset of highly studied MDs, collated into a table. Together with references to key publications describing these models, this brief but detailed overview would be useful for those interested in, or working with, mouse models of MD.<\/jats:p>","DOI":"10.1242\/dmm.043562","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T15:05:16Z","timestamp":1582297516000},"source":"Crossref","is-referenced-by-count":59,"title":["Mouse models for muscular dystrophies: an overview"],"prefix":"10.1242","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-8897","authenticated-orcid":false,"given":"Maaike","family":"van Putten","sequence":"first","affiliation":[{"name":"Leiden University Medical Center 1 , Department of Human Genetics, Leiden, 2333 ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"The University of Western Australia, School of Human Sciences 2 , Perth 6009 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-6098","authenticated-orcid":false,"given":"Jessica C.","family":"de Greef","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center 1 , Department of Human Genetics, Leiden, 2333 ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-1952","authenticated-orcid":false,"given":"Vered","family":"Raz","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center 1 , Department of Human Genetics, Leiden, 2333 ZA , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-0900","authenticated-orcid":false,"given":"Raffaella","family":"Willmann","sequence":"additional","affiliation":[{"name":"University of Basel, Biozentrum 3 , Basel, CH-4056 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-9402","authenticated-orcid":false,"given":"Miranda D.","family":"Grounds","sequence":"additional","affiliation":[{"name":"The University of Western Australia, School of Human Sciences 2 , Perth 6009 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"key":"2024061010065007300_DMM043562C123","doi-asserted-by":"publisher","first-page":"dmm041673","DOI":"10.1242\/dmm.041673","article-title":"The use of genetically humanized animal models for personalized medicine approaches","volume":"13","author":"Aartsma-Rus","year":"2020","journal-title":"Dis. 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