{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:12:11Z","timestamp":1790741531059,"version":"4.1.0"},"reference-count":30,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Metastasis is facilitated by the formation of pre-metastatic niches through the remodelling of the extracellular matrix (ECM) promoted by haematopoietic and stromal cells. The impact of these primed sites is pronounced for intraperitoneal metastases, where the cavity-exposed ECM supports the attachment of the disseminating tumour cells. Likewise, implantation of biomaterial scaffolds influences metastatic progression systemically through a foreign body reaction (FBR). In this study, we integrated the concept of creating an artificial niche to capture tumour cells actively disseminating in the peritoneal cavity with a therapeutic strategy modulating the interactions of metastatic cells with the ECM. The aim was to transform a disseminated disease into a focal disease. For this, we designed and developed a \u2018biomimetic\u2019 ECM composed of a nonresorbable three-dimensional scaffold with collagen coating and characterized the FBR to the implanted biomaterial. We also analysed the safety of the implanted devices and their ability to capture tumour cells in different murine preclinical models of advanced ovarian cancer. Implantation of the biomimetic devices resulted in an initial inflammatory reaction that transformed progressively into a fibrous connective tissue response. The adhesive capabilities of the scaffold were improved with the ancillary effect of the FBR and showed clinical utility in terms of the efficacy of capture of tumour cells, disease focalization and survival benefit. These results demonstrated the performance and safety of this \u2018biomimetic\u2019 ECM in preclinical models of advanced ovarian cancer. Translated into the clinical setting, this new therapeutic strategy represents the possibility for control of peritoneal carcinomatosis upon primary ovarian debulking surgery and to expand the percentage of patients who are candidates for second rescue surgeries at the time of relapse.<\/jats:p>","DOI":"10.1242\/dmm.043653","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T20:17:06Z","timestamp":1592425026000},"source":"Crossref","is-referenced-by-count":7,"title":["Biomimetic device and foreign body reaction cooperate for efficient tumour cell capture in murine advanced ovarian cancer"],"prefix":"10.1242","volume":"13","author":[{"given":"Lorena","family":"Alonso-Alconada","sequence":"first","affiliation":[{"name":"Translational Medical Oncology (oncomet), CIBERONC, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (SERGAS) 1 , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Translational Medical Oncology (oncomet), CIBERONC, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (SERGAS) 1 , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Santacana","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, CIBERONC 2 , Lleida 08080 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Ferreiros","sequence":"additional","affiliation":[{"name":"Translational Medical Oncology (oncomet), CIBERONC, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (SERGAS) 1 , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1315-655X","authenticated-orcid":false,"given":"Rafael","family":"Lopez-Lopez","sequence":"additional","affiliation":[{"name":"Translational Medical Oncology (oncomet), CIBERONC, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (SERGAS) 1 , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Matias-Guiu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, CIBERONC 2 , Lleida 08080 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3533-7781","authenticated-orcid":false,"given":"Miguel","family":"Abal","sequence":"additional","affiliation":[{"name":"Translational Medical Oncology (oncomet), CIBERONC, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (SERGAS) 1 , Santiago de Compostela 15706 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"2024061302434238900_DMM043653C1","doi-asserted-by":"publisher","first-page":"0077","DOI":"10.1038\/s41551-017-0077","article-title":"Engineering the pre-metastatic niche","volume":"1","author":"Aguado","year":"2017","journal-title":"Nat. Biomed. Eng."},{"key":"2024061302434238900_DMM043653C2","doi-asserted-by":"publisher","first-page":"e1700903","DOI":"10.1002\/adhm.201700903","article-title":"Biomaterial scaffolds as pre-metastatic niche mimics systemically alter the primary tumor and tumor microenvironment","volume":"7","author":"Aguado","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"2024061302434238900_DMM043653C3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. Immunol."},{"key":"2024061302434238900_DMM043653C4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal cisplatin and paclitaxel in ovarian cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2024061302434238900_DMM043653C5","doi-asserted-by":"publisher","first-page":"8094","DOI":"10.1038\/ncomms9094","article-title":"In vivo capture and label-free detection of early metastatic cells","volume":"6","author":"Azarin","year":"2015","journal-title":"Nat. Commun."},{"key":"2024061302434238900_DMM043653C6","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1056\/NEJMra041842","article-title":"Cancer of the ovary","volume":"351","author":"Cannistra","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2024061302434238900_DMM043653C7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.critrevonc.2006.03.004","article-title":"Ovarian cancer","volume":"60","author":"Colombo","year":"2006","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"2024061302434238900_DMM043653C8","doi-asserted-by":"publisher","first-page":"djv184","DOI":"10.1093\/jnci\/djv184","article-title":"M-trap: exosome-based capture of tumor cells as a new technology in peritoneal metastasis","volume":"107","author":"de La Fuente","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"2024061302434238900_DMM043653C9","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jse.2010.08.013","article-title":"Rotator cuff repair augmentation using a novel polycarbonate polyurethane patch: preliminary results at 12 months\u2019 follow-up","volume":"20","author":"Encalada-Diaz","year":"2011","journal-title":"J. Shoulder Elbow Surg."},{"key":"2024061302434238900_DMM043653C10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ejca.2015.12.016","article-title":"Targeting the tumour microenvironment in ovarian cancer","volume":"56","author":"Hansen","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"2024061302434238900_DMM043653C11","doi-asserted-by":"publisher","first-page":"C955","DOI":"10.1152\/ajpcell.00326.2015","article-title":"Structural ECM components in the premetastatic and metastatic niche","volume":"310","author":"H\u00f8ye","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2024061302434238900_DMM043653C12","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"2024061302434238900_DMM043653C13","doi-asserted-by":"publisher","first-page":"4614","DOI":"10.1172\/JCI74778","article-title":"Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion","volume":"124","author":"Kenny","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2024061302434238900_DMM043653C14","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3322\/caac.21277","article-title":"Looking up: recent advances in understanding and treating peritoneal carcinomatosis","volume":"65","author":"Lambert","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"2024061302434238900_DMM043653C15","doi-asserted-by":"publisher","first-page":"7692","DOI":"10.3748\/wjg.v22.i34.7692","article-title":"Pathophysiology of colorectal peritoneal carcinomatosis: role of the peritoneum","volume":"22","author":"Lemoine","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"2024061302434238900_DMM043653C16","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2024061302434238900_DMM043653C17","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1083\/jcb.201102147","article-title":"The extracellular matrix: a dynamic niche in cancer progression","volume":"196","author":"Lu","year":"2012","journal-title":"J. Cell Biol."},{"key":"2024061302434238900_DMM043653C18","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1021\/acs.jproteome.8b00750","article-title":"Proteomic characterization of epithelial-like extracellular vesicles in advanced endometrial cancer","volume":"18","author":"Mariscal","year":"2019","journal-title":"J. Proteome Res."},{"key":"2024061302434238900_DMM043653C19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s00018-017-2663-1","article-title":"The peritoneal \u201csoil\u201d for a cancerous \u201cseed\u201d: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases","volume":"75","author":"Miku\u0142a-Pietrasik","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"2024061302434238900_DMM043653C20","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1056\/NEJMoa1611310","article-title":"Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer","volume":"375","author":"Mirza","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2024061302434238900_DMM043653C21","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2217\/WHE.15.6","article-title":"The next steps in improving the outcomes of advanced ovarian cancer","volume":"11","author":"Openshaw","year":"2015","journal-title":"Womens Health"},{"key":"2024061302434238900_DMM043653C22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.semcancer.2011.01.002","article-title":"The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts","volume":"21","author":"Peinado","year":"2011","journal-title":"Semin. Cancer Biol."},{"key":"2024061302434238900_DMM043653C23","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrc.2017.6","article-title":"Pre-metastatic niches: organ-specific homes for metastases","volume":"17","author":"Peinado","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"suppl. 8","key":"2024061302434238900_DMM043653C24","doi-asserted-by":"publisher","first-page":"viii51","DOI":"10.1093\/annonc\/mdx441","article-title":"Treatment of recurrent ovarian cancer","volume":"28","author":"Pignata","year":"2017","journal-title":"Ann. Oncol."},{"key":"2024061302434238900_DMM043653C25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","article-title":"Hematogenous metastasis of ovarian cancer: rethinking mode of spread","volume":"26","author":"Pradeep","year":"2014","journal-title":"Cancer Cell"},{"key":"2024061302434238900_DMM043653C26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"2024061302434238900_DMM043653C27","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s10555-012-9373-9","article-title":"The metastatic niche and stromal progression","volume":"31","author":"Sleeman","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"2024061302434238900_DMM043653C28","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10555-012-9351-2","article-title":"Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis","volume":"31","author":"Sodek","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"2024061302434238900_DMM043653C29","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1089\/ten.tec.2010.0179","article-title":"Ectopic human mesenchymal stem cell-coated scaffolds in NOD\/SCID mice: an in vivo model of the leukemia niche","volume":"16","author":"Vaiselbuh","year":"2010","journal-title":"Tissue Eng. C Methods"},{"key":"2024061302434238900_DMM043653C30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fonc.2017.00024","article-title":"The unique molecular and cellular microenvironment of ovarian cancer","volume":"7","author":"Worzfeld","year":"2017","journal-title":"Front. Oncol."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.043653\/3485097\/dmm043653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.043653\/3485097\/dmm043653.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T02:44:04Z","timestamp":1718246644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/13\/6\/dmm043653\/225250\/Biomimetic-device-and-foreign-body-reaction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.043653","relation":{},"ISSN":["1754-8411","1754-8403"],"issn-type":[{"value":"1754-8411","type":"electronic"},{"value":"1754-8403","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,1]]},"article-number":"dmm043653"}}