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The Syrian hamster is an important model animal for infectious diseases, behavioral, and metabolic science for which more experimental tools are becoming available. Here, we describe the generation and characterization of an interleukin-2 receptor subunit gamma (IL2RG) knockout (KO) Syrian hamster strain. In humans, mutations in IL2RG can result in a total failure in T and natural killer (NK) lymphocyte development and nonfunctional B lymphocytes (X-linked severe combined immunodeficiency; XSCID). Therefore, we sought to develop a non-murine model to study XSCID and the infectious diseases associated with IL2RG deficiency. We demonstrated that the IL2RG KO hamsters have a lymphoid compartment that is greatly reduced in size and diversity and is impaired in function. As a result of the defective adaptive immune response, IL2RG KO hamsters developed a more severe human adenovirus infection and cleared virus less efficiently than immune competent wild-type (wt) hamsters. Due to this enhanced virus replication, IL2RG KO hamsters developed more severe adenovirus-induced liver pathology than wt hamsters. This novel hamster strain will provide researchers with a new tool to investigate human XSCID and its related infections.<\/jats:p>","DOI":"10.1242\/dmm.044602","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T13:02:37Z","timestamp":1594386157000},"source":"Crossref","is-referenced-by-count":14,"title":["Generation and characterization of an <i>IL2RG<\/i> knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients"],"prefix":"10.1242","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoling","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline F.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322, USA"},{"name":"National Center for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Brien","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohe","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China"},{"name":"Centre for Biomarkers & Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S. 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