{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:45:35Z","timestamp":1790801135285,"version":"4.1.0"},"reference-count":181,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by exposure to high levels of oxygen (hyperoxia) and is the most common complication that affects preterm newborns. At present, there is no cure for BPD. Infants can recover from BPD; however, they will suffer from significant morbidity into adulthood in the form of neurodevelopmental impairment, asthma and emphysematous changes of the lung. The development of hyperoxia-induced lung injury models in small and large animals to test potential treatments for BPD has shown some success, yet a lack of standardization in approaches and methods makes clinical translation difficult. In vitro models have also been developed to investigate the molecular pathways altered during BPD and to address the pitfalls associated with animal models. Preclinical studies have investigated the efficacy of stem cell-based therapies to improve lung morphology after damage. However, variability regarding the type of animal model and duration of hyperoxia to elicit damage exists in the literature. These models should be further developed and standardized, to cover the degree and duration of hyperoxia, type of animal model, and lung injury endpoint, to improve their translational relevance. The purpose of this Review is to highlight concerns associated with current animal models of hyperoxia-induced BPD and to show the potential of in vitro models to complement in vivo studies in the significant improvement to our understanding of BPD pathogenesis and treatment. The status of current stem cell therapies for treatment of BPD is also discussed. We offer suggestions to optimize models and therapeutic modalities for treatment of hyperoxia-induced lung damage in order to advance the standardization of procedures for clinical translation.<\/jats:p>","DOI":"10.1242\/dmm.047753","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T04:36:24Z","timestamp":1614054984000},"source":"Crossref","is-referenced-by-count":93,"title":["Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies"],"prefix":"10.1242","volume":"14","author":[{"given":"Kiersten","family":"Giusto","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington, 06106 CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-5834","authenticated-orcid":false,"given":"Heather","family":"Wanczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington, 06106 CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington, 06106 CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-7844","authenticated-orcid":false,"given":"Christine","family":"Finck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Connecticut Health Center, Farmington, 06106 CT, USA"},{"name":"Department of Surgery, Connecticut Children's Medical Center, Hartford, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"2021042701074318400_DMM047753C1","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3349\/ymj.2013.54.2.416","article-title":"Long-term (postnatal day 70) outcome and safety of intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells in neonatal hyperoxic lung injury","volume":"54","author":"Ahn","year":"2013","journal-title":"Yonsei Med. J."},{"key":"2021042701074318400_DMM047753C2","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.jcyt.2015.03.008","article-title":"Cell type-dependent variation in paracrine potency determines therapeutic efficacy against neonatal hyperoxic lung injury","volume":"17","author":"Ahn","year":"2015","journal-title":"Cytotherapy"},{"key":"2021042701074318400_DMM047753C3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jpeds.2017.02.061","article-title":"Two-year follow-up outcomes of premature infants enrolled in the phase i trial of mesenchymal stem cells transplantation for bronchopulmonary dysplasia","volume":"185","author":"Ahn","year":"2017","journal-title":"J. Pediatr."},{"key":"2021042701074318400_DMM047753C4","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1152\/ajplung.00178.2014","article-title":"Utility of large-animal models of BPD: chronically ventilated preterm lambs","volume":"308","author":"Albertine","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C5","doi-asserted-by":"publisher","DOI":"10.1101\/2020.11.13.382390","article-title":"Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease","author":"Alysandratos","year":"2020","journal-title":"bioRxiv"},{"key":"2021042701074318400_DMM047753C6","doi-asserted-by":"publisher","first-page":"L924","DOI":"10.1152\/ajplung.00355.2016","article-title":"Searching for better animal models of BPD: a perspective","volume":"311","author":"Ambalavanan","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C7","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.freeradbiomed.2004.12.004","article-title":"Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells","volume":"38","author":"Asikainen","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"2021042701074318400_DMM047753C8","doi-asserted-by":"publisher","first-page":"10212","DOI":"10.1073\/pnas.0504520102","article-title":"Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung","volume":"102","author":"Asikainen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701074318400_DMM047753C176","doi-asserted-by":"publisher","author":"Aslam","year":"2009","DOI":"10.1164\/rccm.200902-0242OC"},{"key":"2021042701074318400_DMM047753C9","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.ajog.2019.11.1186","article-title":"1174: IL-6 knockout decreases severity of lung injury in an experimental model of bronchopulmonary dysplasia (BPD)","volume":"222","author":"Aziz","year":"2020","journal-title":"J Obstet Gynaecol"},{"key":"2021042701074318400_DMM047753C10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/ppul.10417","article-title":"CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplasia","volume":"37","author":"Baier","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"2021042701074318400_DMM047753C11","doi-asserted-by":"publisher","first-page":"e026265","DOI":"10.1136\/bmjopen-2018-026265","article-title":"Human amnion cells for the prevention of bronchopulmonary dysplasia: a protocol for a phase I dose escalation study","volume":"9","author":"Baker","year":"2019","journal-title":"BMJ Open"},{"key":"2021042701074318400_DMM047753C12","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1056\/NEJMra067279","article-title":"Chronic lung disease after premature birth","volume":"357","author":"Baraldi","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"2021042701074318400_DMM047753C13","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1172\/JCI68782","article-title":"Type 2 alveolar cells are stem cells in adult lung","volume":"123","author":"Barkauskas","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2021042701074318400_DMM047753C14","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1242\/dev.140103","article-title":"Lung organoids: current uses and future promise","volume":"144","author":"Barkauskas","year":"2017","journal-title":"Development"},{"key":"2021042701074318400_DMM047753C15","first-page":"365","article-title":"Cytokine response during hyperoxia: sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats","volume":"2","author":"Ben-Ari","year":"2000","journal-title":"Isr. Med. Assoc. J."},{"key":"2021042701074318400_DMM047753C16","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1152\/ajplung.00159.2014","article-title":"Animal models of bronchopulmonary dysplasia. The term mouse models","volume":"307","author":"Berger","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.siny.2010.03.009","article-title":"Hyperoxia-derived lung damage in preterm infants","volume":"15","author":"Bhandari","year":"2010","journal-title":"Semin. Fetal Neonatal. Med."},{"key":"2021042701074318400_DMM047753C18","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1164\/rccm.201203-0406OC","article-title":"Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia","volume":"186","author":"Bhattacharya","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021042701074318400_DMM047753C19","doi-asserted-by":"publisher","first-page":"2740","DOI":"10.4049\/jimmunol.1101495","article-title":"NF-\u03baB signaling in fetal lung macrophages disrupts airway morphogenesis","volume":"187","author":"Blackwell","year":"2011","journal-title":"J. Immunol."},{"key":"2021042701074318400_DMM047753C20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/2249-4847.109230","article-title":"Stem cell therapy for neonatal diseases associated with preterm birth","volume":"2","author":"Borghesi","year":"2013","journal-title":"J. Clin. Neonatol."},{"key":"2021042701074318400_DMM047753C21","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1152\/ajplung.00415.2001","article-title":"Dynamics of metalloproteinase-2 and -9, TGF-\u03b2, and uPA activities during normoxic vs. hyperoxic alveolarization","volume":"283","author":"Buckley","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C22","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.3727\/096368911X565038a","article-title":"Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats","volume":"20","author":"Chang","year":"2011","journal-title":"Cell Transplant."},{"key":"2021042701074318400_DMM047753C23","doi-asserted-by":"publisher","first-page":"e52419","DOI":"10.1371\/journal.pone.0052419","article-title":"Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042701074318400_DMM047753C24","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.jpeds.2013.12.011","article-title":"Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial","volume":"164","author":"Chang","year":"2014","journal-title":"J. Pediatr."},{"key":"2021042701074318400_DMM047753C25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13148-018-0469-0","article-title":"Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model","volume":"10","author":"Chao","year":"2018","journal-title":"Clin. Epigenet."},{"key":"2021042701074318400_DMM047753C26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1203\/PDR.0b013e3180987202","article-title":"Up-regulation of connective tissue growth factor in hyperoxia-induced lung fibrosis","volume":"62","author":"Chen","year":"2007","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C27","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1152\/ajplung.00441.2007","article-title":"Role of matrix metalloprotease-9 in hyperoxic injury in developing lung","volume":"295","author":"Chetty","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C28","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1164\/ajrccm.160.4.9810071","article-title":"Neonatal chronic lung disease in extremely immature baboons","volume":"160","author":"Coalson","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021042701074318400_DMM047753C29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/ppul.23520","article-title":"The influence of gender on respiratory outcomes in children with bronchopulmonary dysplasia during the first 3 years of life","volume":"52","author":"Collaco","year":"2017","journal-title":"Pediatr. Pulmonol."},{"key":"2021042701074318400_DMM047753C30","doi-asserted-by":"publisher","first-page":"L959","DOI":"10.1152\/ajplung.00228.2014","article-title":"Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models","volume":"307","author":"D'angio","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1080\/019021499270187","article-title":"Discordant pulmonary proinflammatory cytokine expression during acute hyperoxia in the newborn rabbit","volume":"25","author":"D'angio","year":"1999","journal-title":"Exp. Lung Res."},{"key":"2021042701074318400_DMM047753C32","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1089\/152308604771978417","article-title":"Increased apoptosis and expression of p21 and p53 in premature infant baboon model of bronchopulmonary dysplasia","volume":"6","author":"Das","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"2021042701074318400_DMM047753C33","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s11892-012-0305-4","article-title":"Harnessing the immunomodulatory and tissue repair properties of mesenchymal stem cells to restore \u03b2 cell function","volume":"12","author":"Davis","year":"2012","journal-title":"Curr. Diab. Rep."},{"key":"2021042701074318400_DMM047753C34","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s12311-012-0406-2","article-title":"Human mesenchymal stem cells increase anti-oxidant defences in cells derived from patients with Friedreich's ataxia","volume":"11","author":"Dey","year":"2012","journal-title":"Cerebellum"},{"key":"2021042701074318400_DMM047753C35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1089\/ped.2010.0007","article-title":"Diagnostic pathology of diffuse lung disease in children","volume":"23","author":"Dishop","year":"2010","journal-title":"Pediatr. Allergy Immunol. Pulmonol."},{"key":"2021042701074318400_DMM047753C36","doi-asserted-by":"publisher","first-page":"L421","DOI":"10.1152\/ajplung.00316.2019","article-title":"Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice","volume":"318","author":"Dolma","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C37","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1165\/rcmb.2019-0079OC","article-title":"FGFR2 is required for AEC2 homeostasis and survival after Bleomycin-induced lung injury","volume":"62","author":"Dorry","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021042701074318400_DMM047753C38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2174\/1573396314666180911100503","article-title":"The therapeutic potential of stem cells for bronchopulmonary dysplasia: \u201cit's about time\u201d or \u201cnot so fast\u201d?","volume":"14","author":"Ee","year":"2018","journal-title":"Curr. Pediatr. Rev."},{"key":"2021042701074318400_DMM047753C39","doi-asserted-by":"publisher","first-page":"e88","DOI":"10.1186\/s12931-019-1063-5","article-title":"Antioxidative effects of caffeine in a hyperoxia-based rat model of bronchopulmonary dysplasia","volume":"20","author":"Endesfelder","year":"2019","journal-title":"Respir. Res."},{"key":"2021042701074318400_DMM047753C177","doi-asserted-by":"publisher","author":"A. E.","year":"2008","DOI":"10.1203\/PDR.0b013e31815b4857"},{"key":"2021042701074318400_DMM047753C178","doi-asserted-by":"publisher","author":"A. E.","year":"2014","DOI":"10.1186\/1465-9921-15-32"},{"key":"2021042701074318400_DMM047753C40","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1165\/rcmb.2008-0176OC","article-title":"Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice","volume":"40","author":"Fritzell","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021042701074318400_DMM047753C41","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jpeds.2019.04.006","article-title":"Airway histopathology of adolescent survivors of bronchopulmonary dysplasia","volume":"211","author":"Galderisi","year":"2019","journal-title":"J. Pediatr."},{"key":"2021042701074318400_DMM047753C42","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1016\/S0002-9440(10)63612-7","article-title":"Transfer of the active form of transforming growth factor-\u03b21 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia","volume":"163","author":"Gauldie","year":"2003","journal-title":"Am. J. Pathol."},{"key":"2021042701074318400_DMM047753C43","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1542\/neo.21-4-e226","article-title":"Ventilation strategies in severe bronchopulmonary dysplasia","volume":"21","author":"Gibbs","year":"2020","journal-title":"NeoReviews"},{"key":"2021042701074318400_DMM047753C44","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/MOP.0b013e328346577f","article-title":"Pathogenesis and treatment of bronchopulmonary dysplasia","volume":"23","author":"Gien","year":"2011","journal-title":"Curr. Opin. Pediatr."},{"key":"2021042701074318400_DMM047753C45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12967-019-1843-1","article-title":"Hyperoxia-induced lung structure-function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model","volume":"17","author":"Greco","year":"2019","journal-title":"J. Transl. Med."},{"key":"2021042701074318400_DMM047753C46","doi-asserted-by":"publisher","first-page":"340","DOI":"10.4161\/org.29198","article-title":"Epithelial-mesenchymal co-culture model for studying alveolar morphogenesis","volume":"10","author":"Greer","year":"2014","journal-title":"Organogenesis"},{"key":"2021042701074318400_DMM047753C47","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1002\/stem.471","article-title":"Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection","volume":"28","author":"Gutierrez-Aranda","year":"2010","journal-title":"Stem Cells"},{"key":"2021042701074318400_DMM047753C179","doi-asserted-by":"publisher","author":"Hansmann","year":"2012","DOI":"10.4103\/2045-8932.97603"},{"key":"2021042701074318400_DMM047753C48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s40635-017-0142-5","article-title":"Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes","volume":"5","author":"Helmerhorst","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"2021042701074318400_DMM047753C49","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.scr.2009.02.002","article-title":"Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies","volume":"2","author":"Hentze","year":"2009","journal-title":"Stem Cell Res."},{"key":"2021042701074318400_DMM047753C50","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41598-018-37193-3","article-title":"Human pluripotent stem cell-derived alveolar epithelial cells are alternatives for in vitro pulmotoxicity assessment","volume":"9","author":"Heo","year":"2019","journal-title":"Sci. Rep."},{"key":"2021042701074318400_DMM047753C51","doi-asserted-by":"publisher","first-page":"L580","DOI":"10.1152\/ajplung.00278.2003","article-title":"FGF signaling is required for pulmonary homeostasis following hyperoxia","volume":"286","author":"Hokuto","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C52","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00156","article-title":"Lung function measurements in rodents in safety pharmacology studies","volume":"3","author":"Hoymann","year":"2012","journal-title":"Front. Pharmacol."},{"key":"2021042701074318400_DMM047753C53","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1164\/rccm.200809-1522ST","article-title":"An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure","volume":"181","author":"Hsia","year":"2010","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2021042701074318400_DMM047753C54","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nbt.2754","article-title":"Efficient generation of lung and airway epithelial cells from human pluripotent stem cells","volume":"32","author":"Huang","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"2021042701074318400_DMM047753C55","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00408-018-0084-z","article-title":"Recent advances in bronchopulmonary dysplasia: pathophysiology, prevention, and treatment","volume":"196","author":"Hwang","year":"2018","journal-title":"Lung"},{"key":"2021042701074318400_DMM047753C56","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41390-018-0167-9","article-title":"The definition of bronchopulmonary dysplasia: an evolving dilemma","volume":"84","author":"Ibrahim","year":"2018","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C57","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.stem.2017.08.014","article-title":"Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells","volume":"21","author":"Jacob","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2021042701074318400_DMM047753C58","doi-asserted-by":"publisher","first-page":"14344","DOI":"10.1038\/s41598-018-32494-z","article-title":"Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification","volume":"8","author":"Jiang","year":"2018","journal-title":"Sci. Rep."},{"key":"2021042701074318400_DMM047753C59","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1159\/000481794","article-title":"Upregulation of vascular endothelial growth factor in amniotic fluid stem cells enhances their potential to attenuate lung injury in a preterm rabbit model of bronchopulmonary dysplasia","volume":"113","author":"Jim\u00e9nez","year":"2018","journal-title":"Neonatology"},{"key":"2021042701074318400_DMM047753C60","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3109\/01902149709039242","article-title":"Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia","volume":"23","author":"Johnston","year":"1997","journal-title":"Exp. Lung Res."},{"key":"2021042701074318400_DMM047753C61","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.rmed.2017.10.014","article-title":"Bronchopulmonary dysplasia: a review of pathogenesis and pathophysiology","volume":"132","author":"Kalikkot Thekkeveedu","year":"2017","journal-title":"Respir. Med."},{"key":"2021042701074318400_DMM047753C62","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1158\/0008-5472.CAN-16-1121","article-title":"Ex vivo explant cultures of non\u2013small cell lung carcinoma enable evaluation of primary tumor responses to anticancer therapy","volume":"77","author":"Karekla","year":"2017","journal-title":"Cancer Res."},{"key":"2021042701074318400_DMM047753C63","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/pr.2016.88","article-title":"Intratracheal transplantation of mesenchymal stem cells simultaneously attenuates both lung and brain injuries in hyperoxic newborn rats","volume":"80","author":"Kim","year":"2016","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C64","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12890-019-0993-5","article-title":"Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation","volume":"19","author":"Kindermann","year":"2019","journal-title":"BMC Pulmonary Med."},{"key":"2021042701074318400_DMM047753C65","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2174\/1874306401307010046","article-title":"Adult rat bone marrow-derived stem cells promote late fetal type II cell differentiation in a co-culture model","volume":"7","author":"Knoll","year":"2013","journal-title":"Open Respir. Med. J."},{"key":"2021042701074318400_DMM047753C66","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1152\/japplphysiol.01100.2009","article-title":"Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach","volume":"108","author":"Knudsen","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"2021042701074318400_DMM047753C67","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1684\/ecn.2012.0304","article-title":"Value of serum and bronchoalveolar fluid lavage pro- and anti-inflammatory cytokine levels for predicting bronchopulmonary dysplasia in premature infants","volume":"23","author":"K\u00f6ksal","year":"2012","journal-title":"Eur. Cytokine Netw."},{"key":"2021042701074318400_DMM047753C68","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1203\/00006450-199608000-00010","article-title":"Increase in interleukin (IL)-1\u03b2 and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity","volume":"40","author":"Kotecha","year":"1996","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C69","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1089\/scd.2014.0184","article-title":"Paracrine factors secreted by umbilical cord-derived mesenchymal stem cells induce angiogenesis in vitro by a VEGF-independent pathway","volume":"24","author":"Kuchroo","year":"2015","journal-title":"Stem Cells Dev."},{"key":"2021042701074318400_DMM047753C70","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1016\/j.lfs.2006.07.040","article-title":"Expression of transforming growth factor beta (TGF-b1) by human preterm lung inflammatory cells","volume":"79","author":"Kwong","year":"2006","journal-title":"Life Sci."},{"key":"2021042701074318400_DMM047753C71","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1067\/S0022-3476(03)00297-X","article-title":"Lower concentration of pulmonary hepatocyte growth factor is associated with more severe lung disease in preterm infants","volume":"143","author":"Lassus","year":"2003","journal-title":"J. Pediatr."},{"key":"2021042701074318400_DMM047753C72","first-page":"119","article-title":"Functional toxicity in the developing heart, lung, and kidney","volume-title":"Developmental Toxicology","author":"Lau","year":"1994","edition":"2 edn."},{"key":"2021042701074318400_DMM047753C73","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.ajpath.2019.01.014","article-title":"Genetic strain and sex differences in a hyperoxia-induced mouse model of varying severity of bronchopulmonary dysplasia","volume":"189","author":"Leary","year":"2019","journal-title":"Am. J. Pathol."},{"key":"2021042701074318400_DMM047753C74","doi-asserted-by":"publisher","first-page":"6479","DOI":"10.1038\/s41598-019-42819-1","article-title":"Mesenchymal stem cells increase alveolar differentiation in lung progenitor organoid cultures","volume":"9","author":"Leeman","year":"2019","journal-title":"Sci. Rep."},{"key":"2021042701074318400_DMM047753C75","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.3892\/etm.2019.7315","article-title":"Loss of interleukin-6 enhances the inflammatory response associated with hyperoxia-induced lung injury in neonatal mice","volume":"17","author":"Li","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"2021042701074318400_DMM047753C76","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/cells9020384","article-title":"WNT5a-ROR signaling is essential for alveologenesis","volume":"9","author":"Li","year":"2020","journal-title":"Cells"},{"key":"2021042701074318400_DMM047753C77","first-page":"A6397","article-title":"Interleukin-10 in experimental bronchopulmonary dysplasia. C77. ADVANCEMENTS IN THE BIOLOGY OF BPD AND OTHER CONGENITAL PEDIATRIC LUNG DISEASES","volume":"2017","author":"Lignelli","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021042701074318400_DMM047753C78","doi-asserted-by":"publisher","first-page":"L832","DOI":"10.1152\/ajplung.00369.2019","article-title":"Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia","volume":"317","author":"Lignelli","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C79","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/sctm.18-0079","article-title":"First-in-human administration of allogeneic amnion cells in premature infants with bronchopulmonary dysplasia: a safety study","volume":"7","author":"Lim","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"2021042701074318400_DMM047753C80","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1164\/rccm.202002-0277ED","article-title":"The Wnt signaling pathway and the development of bronchopulmonary dysplasia","volume":"201","author":"Lingappan","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021042701074318400_DMM047753C81","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.tox.2015.01.019","article-title":"Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A","volume":"331","author":"Lingappan","year":"2015","journal-title":"Toxicology"},{"key":"2021042701074318400_DMM047753C82","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1016\/j.ajpath.2014.08.010","article-title":"Intranasal versus intraperitoneal delivery of human umbilical cord tissue-derived cultured mesenchymal stromal cells in a murine model of neonatal lung injury","volume":"184","author":"Liu","year":"2014","journal-title":"Am. J. Pathol."},{"key":"2021042701074318400_DMM047753C83","doi-asserted-by":"publisher","first-page":"e109953","DOI":"10.1371\/journal.pone.0109953","article-title":"Induced pluripotent stem cell therapy ameliorates hyperoxia-augmented ventilator-induced lung injury through suppressing the Src pathway","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS ONE"},{"key":"2021042701074318400_DMM047753C84","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1152\/japplphysiol.00464.2006","article-title":"Restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice","volume":"101","author":"Lofgren","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"2021042701074318400_DMM047753C85","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.3892\/mmr.2014.2959","article-title":"Bone marrow-derived mesenchymal stem cells protect against lung injury in a mouse model of bronchopulmonary dysplasia","volume":"11","author":"Luan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"2021042701074318400_DMM047753C86","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1203\/00006450-200302000-00009","article-title":"Lung epithelial cells undergo apoptosis in neonatal respiratory distress syndrome","volume":"53","author":"Lukkarinen","year":"2003","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C87","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.biocel.2005.02.024","article-title":"Hyperoxia results in transient oxidative stress and an adaptive response by antioxidant enzymes in goldfish tissues","volume":"37","author":"Lushchak","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021042701074318400_DMM047753C88","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.clp.2019.02.011","article-title":"Drugs for the prevention and treatment of bronchopulmonary dysplasia","volume":"46","author":"Mandell","year":"2019","journal-title":"Clin. Perinatol."},{"key":"2021042701074318400_DMM047753C89","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-435","article-title":"Severe bronchopulmonary dysplasia improved by noninvasive positive pressure ventilation: a case report","volume":"5","author":"Mann","year":"2011","journal-title":"J. Med. Case Rep."},{"key":"2021042701074318400_DMM047753C90","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1006\/mgme.2000.3046","article-title":"Signal transduction pathways in hyperoxia-induced lung cell death","volume":"71","author":"Mantell","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"2021042701074318400_DMM047753C91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2020.1760826","article-title":"Vascular endothelial growth factor levels and bronchopulmonary dysplasia in preterm infants","volume":"4","author":"Mariduena","year":"2020","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"2021042701074318400_DMM047753C92","doi-asserted-by":"publisher","first-page":"13789","DOI":"10.1074\/jbc.M115.670521","article-title":"Tumor necrosis factor-stimulated gene 6 (tsg-6)-mediated interactions with the inter-\u03b1-inhibitor heavy chain 5 facilitate Tumor Growth Factor \u03b21 (TGF\u03b21)-dependent fibroblast to myofibroblast differentiation","volume":"291","author":"Martin","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2021042701074318400_DMM047753C93","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.clp.2015.08.014","article-title":"The natural history of Bronchopulmonary Dysplasia (BPD): the case for primary prevention","volume":"42","author":"Mcevoy","year":"2015","journal-title":"Clin. Perinatol."},{"key":"2021042701074318400_DMM047753C94","doi-asserted-by":"publisher","first-page":"e0173572","DOI":"10.1371\/journal.pone.0173572","article-title":"Human amnion epithelial cells modulate the inflammatory response to ventilation in preterm lambs","volume":"12","author":"Melville","year":"2017","journal-title":"PLoS ONE"},{"key":"2021042701074318400_DMM047753C95","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bbrc.2017.04.112","article-title":"Hyperoxia exposure disrupts adrenomedullin signaling in newborn mice: Implications for lung development in premature infants","volume":"487","author":"Menon","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042701074318400_DMM047753C96","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.diff.2017.08.001","article-title":"Production of high purity alveolar-like cells from iPSCs through depletion of uncommitted cells after AFE induction","volume":"96","author":"Mitchell","year":"2017","journal-title":"Differentiation"},{"key":"2021042701074318400_DMM047753C97","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.diff.2019.01.003","article-title":"Assessment of iPSC teratogenicity throughout directed differentiation toward an alveolar-like phenotype","volume":"105","author":"Mitchell","year":"2019","journal-title":"Differentiation"},{"key":"2021042701074318400_DMM047753C98","first-page":"292","article-title":"Human induced pluripotent stem cells ameliorate hyperoxia-induced lung injury in a mouse model","volume":"12","author":"Mitchell","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"2021042701074318400_DMM047753C99","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2015.00050","article-title":"Stem cells and their mediators \u2013 next generation therapy for bronchopulmonary dysplasia","volume":"2","author":"M\u00f6bius","year":"2015","journal-title":"Front. Med."},{"key":"2021042701074318400_DMM047753C100","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1165\/rcmb.2018-0358OC","article-title":"Oxygen disrupts human fetal lung mesenchymal cells. Implications for bronchopulmonary dysplasia","volume":"60","author":"M\u00f6bius","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021042701074318400_DMM047753C101","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V108.11.1687.1687","article-title":"Perivascular human umbilical cord cells are capable of long term culture and respond to chemotactic gradient in an in vitro-model of alveolar damage","volume":"108","author":"Montemurro","year":"2006","journal-title":"Blood"},{"key":"2021042701074318400_DMM047753C102","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1038\/s41598-019-42103-2","article-title":"Development of an ex vivo respiratory pediatric model of bronchopulmonary dysplasia for aerosol deposition studies","volume":"9","author":"Montigaud","year":"2019","journal-title":"Sci. Rep."},{"key":"2021042701074318400_DMM047753C103","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3109\/14767058.2011.607675","article-title":"BPD: old and new problems","volume":"24","author":"Mosca","year":"2011","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"2021042701074318400_DMM047753C104","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/978-1-62703-056-4_18","article-title":"Stereology and morphometry of lung tissue","volume":"931","author":"M\u00fchlfeld","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"2021042701074318400_DMM047753C105","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1203\/01.PDR.0000112104.48903.3C","article-title":"Lung inflammatory responses to intratracheal interleukin-1\u03b1 in ventilated preterm lambs","volume":"55","author":"Mulrooney","year":"2004","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C106","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1152\/japplphysiol.00202.2004","article-title":"Vascular endothelial growth factor and related molecules in acute lung injury","volume":"97","author":"Mura","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"2021042701074318400_DMM047753C107","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/ped.14001","article-title":"Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia","volume":"61","author":"Namba","year":"2019","journal-title":"Pediatr. Int."},{"key":"2021042701074318400_DMM047753C108","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00441-016-2534-3","article-title":"Looking ahead: where to next for animal models of bronchopulmonary dysplasia?","volume":"367","author":"Nardiello","year":"2017","journal-title":"Cell Tissue Res."},{"key":"2021042701074318400_DMM047753C109","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1242\/dmm.027086","article-title":"Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia","volume":"10","author":"Nardiello","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2021042701074318400_DMM047753C110","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-381422-7.10006-9","article-title":"Chapter 6 - Scarless wound healing","volume-title":"Principles of Regenerative Medicine","author":"Nauta","year":"2011","edition":"2nd edn."},{"key":"2021042701074318400_DMM047753C111","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1369\/0022155415617988","article-title":"Expression of WNT5A in idiopathic pulmonary fibrosis and its control by TGF-\u03b2 and WNT7B in human lung fibroblasts","volume":"64","author":"Newman","year":"2016","journal-title":"J. Histochem. Cytochem,"},{"key":"2021042701074318400_DMM047753C112","doi-asserted-by":"publisher","first-page":"14384","DOI":"10.1073\/pnas.1306859110","article-title":"Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia","volume":"110","author":"Nold","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701074318400_DMM047753C113","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia","volume":"276","author":"Northway","year":"1967","journal-title":"N. Engl. J. Med."},{"key":"2021042701074318400_DMM047753C114","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40348-017-0076-8","article-title":"The BPD trio? Interaction of dysregulated Pdgf, Vegf, and TGF signaling in neonatal chronic lung disease","volume":"4","author":"Oak","year":"2017","journal-title":"Mol. Cell. Pediatr."},{"key":"2021042701074318400_DMM047753C115","doi-asserted-by":"publisher","first-page":"L15","DOI":"10.1152\/ajplung.00429.2012","article-title":"Quantitative microscopy of the lung: a problem-based approach. Part 1: basic principles of lung stereology","volume":"305","author":"Ochs","year":"2013","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C116","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1152\/ajplung.00160.2014","article-title":"Animal models of bronchopulmonary dysplasia: the term rat models","volume":"207","author":"O'reilly","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C117","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.101683","article-title":"Oxidative stress and bronchopulmonary dysplasia","author":"Perrone","year":"2012","journal-title":"J. Clin. Neonatol."},{"key":"2021042701074318400_DMM047753C118","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1136\/thoraxjnl-2012-202323","article-title":"Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia","volume":"68","author":"Pierro","year":"2013","journal-title":"Thorax"},{"key":"2021042701074318400_DMM047753C119","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1289\/ehp.00108s3457","article-title":"The mammalian respiratory system and critical windows of exposure for children's health","volume":"108","author":"Pinkerton","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"2021042701074318400_DMM047753C120","doi-asserted-by":"publisher","first-page":"L231","DOI":"10.1152\/ajplung.00342.2013","article-title":"Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia","volume":"307","author":"Popova","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C121","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jpeds.2019.02.029","article-title":"Safety of intratracheal administration of human umbilical cord blood derived mesenchymal stromal cells in extremely low birth weight preterm infants","volume":"210","author":"Powell","year":"2019","journal-title":"J. Pediatr."},{"key":"2021042701074318400_DMM047753C122","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12967-018-1417-7","article-title":"Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies","volume":"16","author":"Principi","year":"2018","journal-title":"J. Transl. Med."},{"key":"2021042701074318400_DMM047753C123","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1097\/00003081-198609000-00006","article-title":"Human fetal lung development and related animal models","volume":"29","author":"Pringle","year":"1986","journal-title":"Clin. Obstet. Gynecol."},{"key":"2021042701074318400_DMM047753C124","doi-asserted-by":"publisher","first-page":"932356","DOI":"10.1155\/2013\/932356","article-title":"Association of a FGFR-4 gene polymorphism with bronchopulmonary dysplasia and neonatal respiratory distress","volume":"35","author":"Rezvani","year":"2013","journal-title":"Dis. Markers"},{"key":"2021042701074318400_DMM047753C125","doi-asserted-by":"publisher","first-page":"L277","DOI":"10.1152\/ajplung.00315.2013","article-title":"Functional assessment of hyperoxia-induced lung injury after preterm birth in the rabbit","volume":"306","author":"Richter","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C126","doi-asserted-by":"publisher","first-page":"e0164269","DOI":"10.1371\/journal.pone.0164269","article-title":"The effect of gender on Mesenchymal Stem Cell (MSC) efficacy in neonatal hyperoxia-induced lung injury","volume":"11","author":"Sammour","year":"2016","journal-title":"PLoS ONE"},{"key":"2021042701074318400_DMM047753C127","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00441-016-2545-0","article-title":"Development of the lung","volume":"367","author":"Schittny","year":"2017","journal-title":"Cell Tissue Res."},{"key":"2021042701074318400_DMM047753C128","doi-asserted-by":"publisher","first-page":"e0175804","DOI":"10.1371\/journal.pone.0175804","article-title":"Influence of prenatal hypoxia and postnatal hyperoxia on morphologic lung maturation in mice","volume":"12","author":"Schmiedl","year":"2017","journal-title":"PLoS ONE"},{"key":"2021042701074318400_DMM047753C129","doi-asserted-by":"publisher","first-page":"621","DOI":"10.2217\/rme.14.29","article-title":"Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro","volume":"9","author":"Schnabel","year":"2014","journal-title":"Regen. Med."},{"key":"2021042701074318400_DMM047753C130","doi-asserted-by":"publisher","first-page":"L341","DOI":"10.1152\/ajplung.00329.2013","article-title":"Alterations of mouse lung tissue dimensions during processing for morphometry: a comparison of methods","volume":"306","author":"Schneider","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C131","doi-asserted-by":"publisher","first-page":"L1098","DOI":"10.1152\/ajplung.00423.2015","article-title":"Hepatocyte growth factor as a downstream mediator of vascular endothelial growth factor-dependent preservation of growth in the developing lung","volume":"310","author":"Seedorf","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C132","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jcyt.2017.09.003","article-title":"Human induced pluripotent stem cell-derived lung progenitor and alveolar epithelial cells attenuate hyperoxia-induced lung injury","volume":"20","author":"Shafa","year":"2018","journal-title":"Cytotherapy"},{"key":"2021042701074318400_DMM047753C133","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40348-016-0051-9","article-title":"Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development","volume":"3","author":"Shahzad","year":"2016","journal-title":"Mol. Cell. Pediatr."},{"key":"2021042701074318400_DMM047753C134","doi-asserted-by":"publisher","first-page":"L1239","DOI":"10.1152\/ajplung.00268.2015","article-title":"Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia","volume":"309","author":"Silva","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021042701074318400_DMM047753C135","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1165\/rcmb.2017-0442MA","article-title":"Successful establishment of primary type II alveolar epithelium with 3D organotypic coculture","volume":"59","author":"Sucre","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021042701074318400_DMM047753C136","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1164\/rccm.201908-1513OC","article-title":"Hyperoxia injury in the developing lung is mediated by mesenchymal expression of Wnt5A","volume":"201","author":"Sucre","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021042701074318400_DMM047753C137","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1651-2227.2004.tb03020.x","article-title":"The role of matrix metalloproteinases -9 and -2 in development of neonatal chronic lung disease","volume":"93","author":"Sweet","year":"2004","journal-title":"Acta Paediatr."},{"key":"2021042701074318400_DMM047753C138","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/ppul.20135","article-title":"Increased lung matrix metalloproteinase-9 levels in extremely premature baboons with bronchopulmonary dysplasia","volume":"39","author":"Tambunting","year":"2005","journal-title":"Pediatr. Pulmonol."},{"key":"2021042701074318400_DMM047753C139","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1161\/CIRCULATIONAHA.105.541524","article-title":"Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury","volume":"112","author":"Th\u00e9baud","year":"2005","journal-title":"Circulation"},{"key":"2021042701074318400_DMM047753C140","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41572-019-0127-7","article-title":"Bronchopulmonary dysplasia","volume":"5","author":"Th\u00e9baud","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2021042701074318400_DMM047753C141","doi-asserted-by":"publisher","first-page":"361","DOI":"10.4137\/BMI.S834","article-title":"Pulmonary biomarkers of bronchopulmonary dysplasia","volume":"3","author":"Thompson","year":"2008","journal-title":"Biomark Insights"},{"key":"2021042701074318400_DMM047753C142","first-page":"1692","article-title":"Intravenous infusion of rat bone marrow-derived mesenchymal stem cells ameliorates hyperoxia-induced lung injury in neonatal rats","volume":"27","author":"Tian","year":"2007","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"2021042701074318400_DMM047753C143","first-page":"4","article-title":"Influence of human bone marrow-derived mesenchymal stem cells on the lung of newborn rats damaged by hyperoxia","volume":"46","author":"Tian","year":"2008","journal-title":"Zhonghua Er Ke Za Zh"},{"key":"2021042701074318400_DMM047753C144","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/ppul.24304","article-title":"Mouse genetic background impacts susceptibility to hyperoxia-driven perturbations to lung maturation","volume":"54","author":"Tiono","year":"2019","journal-title":"Pediatr. Pulmonol."},{"key":"2021042701074318400_DMM047753C145","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1042\/BST20180079","article-title":"MSC exosome works through a protein-based mechanism of action","volume":"46","author":"Toh","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"2021042701074318400_DMM047753C146","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3892\/mmr.2020.11671","article-title":"Hyperoxia induces endoplasmic reticulum stress-associated apoptosis via the IRE1\u03b1 pathway in rats with bronchopulmonary dysplasia","volume":"23","author":"Tong","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"2021042701074318400_DMM047753C147","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1203\/PDR.0b013e31806772a1","article-title":"Developmental cell\/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia","volume":"62","author":"Torday","year":"2007","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C180","doi-asserted-by":"publisher","author":"K. A.","year":"2012","DOI":"10.1152\/ajplung.00347.2011"},{"key":"2021042701074318400_DMM047753C148","doi-asserted-by":"publisher","first-page":"8242","DOI":"10.1073\/pnas.1511236113","article-title":"Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity","volume":"113","author":"Tsao","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042701074318400_DMM047753C149","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1165\/rcmb.2009-0004OC","article-title":"Adrenomedullin promotes lung angiogenesis, alveolar development, and repair","volume":"43","author":"Vadivel","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021042701074318400_DMM047753C150","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1164\/rccm.200902-0179OC","article-title":"Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats","volume":"180","author":"van Haaften","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021042701074318400_DMM047753C151","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1080\/01902140802389693","article-title":"Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia","volume":"34","author":"von Bismarck","year":"2009","journal-title":"Exp. Lung Res."},{"key":"2021042701074318400_DMM047753C152","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.jcyt.2013.03.004","article-title":"Human amnion epithelial cells modulate hyperoxia-induced neonatal lung injury in mice","volume":"15","author":"Vosdoganes","year":"2013","journal-title":"Cytotherapy"},{"key":"2021042701074318400_DMM047753C153","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.freeradbiomed.2003.12.007","article-title":"Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress","volume":"36","author":"Wagenaar","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"2021042701074318400_DMM047753C154","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.gene.2018.08.031","article-title":"Oxidative stress and bronchopulmonary dysplasia","volume":"678","author":"Wang","year":"2018","journal-title":"Gene"},{"key":"2021042701074318400_DMM047753C155","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.devcel.2013.01.012","article-title":"Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1\/2-Bmp4\/Rb1 regulatory pathway","volume":"24","author":"Wang","year":"2013","journal-title":"Dev. Cell"},{"key":"2021042701074318400_DMM047753C156","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.gene.2013.10.004","article-title":"GSTM1 and GSTT1 gene polymorphisms as major risk factors for bronchopulmonary dysplasia in a Chinese Han population","volume":"533","author":"Wang","year":"2014","journal-title":"Gene"},{"key":"2021042701074318400_DMM047753C157","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/bs.mcb.2020.03.008","article-title":"Chapter 5 - Differentiation of human airway-organoids from induced pluripotent stem cells (iPSCs)","volume-title":"Methods in Cell Biology","author":"Wang","year":"2020"},{"key":"2021042701074318400_DMM047753C158","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1165\/ajrcmb.22.5.3808","article-title":"Interleukin-6-induced protection in hyperoxic acute lung injury","volume":"22","author":"Ward","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021042701074318400_DMM047753C159","doi-asserted-by":"publisher","first-page":"L110","DOI":"10.1152\/ajplung.1998.275.1.L110","article-title":"Functional and pathological effects of prolonged hyperoxia in neonatal mice","volume":"275","author":"Warner","year":"1998","journal-title":"Am. J. Physiol."},{"key":"2021042701074318400_DMM047753C160","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1152\/japplphysiol.00808.2006","article-title":"How much is there really? Why stereology is essential in lung morphometry","volume":"102","author":"Weibel","year":"2007","journal-title":"J. Appl. Physiol.,"},{"key":"2021042701074318400_DMM047753C161","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/jmri.26623","article-title":"Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications","volume":"50","author":"Westcott","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"key":"2021042701074318400_DMM047753C162","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00251-006-0147-9","article-title":"Genetic basis of murine responses to hyperoxia-induced lung injury","volume":"58","author":"Whitehead","year":"2006","journal-title":"Immunogenetics"},{"key":"2021042701074318400_DMM047753C163","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1152\/ajpregu.00286.2018","article-title":"Strain-dependent effects on lung structure, matrix remodeling, and Stat3\/Smad2 signaling in C57BL\/6N and C57BL\/6J mice after neonatal hyperoxia","volume":"317","author":"Will","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042701074318400_DMM047753C164","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/pr.2017.256","article-title":"\u201cGood things come in small packages\u201d: application of exosome-based therapeutics in neonatal lung injury","volume":"83","author":"Willis","year":"2018","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C165","doi-asserted-by":"publisher","first-page":"407","DOI":"10.5935\/1676-2444.20160064","article-title":"Immunohistochemical analysis of apoptosis and cell proliferation in lungs of premature infants with chronic lung disease (bronchopulmonary dysplasia)","volume":"52","author":"Witkowski","year":"2016","journal-title":"J. Brasileiro Patol. Med. Lab."},{"key":"2021042701074318400_DMM047753C166","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1016\/j.bbrc.2017.11.193","article-title":"Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K\/Akt\/Foxo3a signaling pathway","volume":"495","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042701074318400_DMM047753C167","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.pedneo.2015.02.001","article-title":"Angiogenic factors in cord blood of preterm infants predicts subsequently developing bronchopulmonary dysplasia","volume":"56","author":"Yang","year":"2015","journal-title":"Pediatr. Neonatol."},{"key":"2021042701074318400_DMM047753C168","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0002-9378(97)70276-X","article-title":"Amniotic Fluid Cytokines (interleukin-6, Tumor Necrosis Factor-\u03b1, interleukin-1\u03b2, and interleukin-8) and the Risk for the Development of Bronchopulmonary Dysplasia","volume":"177","author":"Yoon","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021042701074318400_DMM047753C169","doi-asserted-by":"publisher","first-page":"L525","DOI":"10.1152\/ajplung.00067.2019","article-title":"Moderate hyperoxia induces senescence in developing human lung fibroblasts","volume":"317","author":"You","year":"2019","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"2021042701074318400_DMM047753C174","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3892\/ijmm.2020.4617","article-title":"Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats","volume":"46","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"2021042701074318400_DMM047753C171","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/j.1399-3046.2012.01709.x","article-title":"Bone marrow mesenchymal stem cells attenuate lung inflammation of hyperoxic newborn rats","volume":"16","author":"Zhang","year":"2012","journal-title":"Pediatr. Transplant."},{"key":"2021042701074318400_DMM047753C172","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1517\/14712598.2013.778969","article-title":"Mesenchymal stem cells protect against neonatal rat hyperoxic lung injury","volume":"13","author":"Zhang","year":"2013","journal-title":"Expert Opin. Biol. Ther."},{"key":"2021042701074318400_DMM047753C170","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1203\/01.PDR.0000155762.91748.8D","article-title":"Responses of pulmonary platelet-derived growth factor peptides and receptors to hyperoxia and nitric oxide in piglet lungs","volume":"57","author":"Zhang","year":"2005","journal-title":"Pediatr. Res."},{"key":"2021042701074318400_DMM047753C181","doi-asserted-by":"publisher","author":"Zhang","year":"2018","DOI":"10.1152\/ajpheart.00416.2018"},{"key":"2021042701074318400_DMM047753C173","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.taap.2017.07.016","article-title":"Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: role of Hif-1\u03b1","volume":"332","author":"Zhang","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021042701074318400_DMM047753C175","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/PCC.0b013e318166fbb5","article-title":"Effects of oxygen concentration and exposure time on cultured human airway epithelial cells","volume":"9","author":"Zhu","year":"2008","journal-title":"Pediatr. Crit. Care Med."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.047753\/1820795\/dmm047753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.047753\/1820795\/dmm047753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T22:48:48Z","timestamp":1619477328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/14\/2\/dmm047753\/237310\/Hyperoxia-induced-bronchopulmonary-dysplasia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":181,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.047753","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"article-number":"dmm047753"}}