{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:04:28Z","timestamp":1792134268551,"version":"4.4.0"},"reference-count":51,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japanese Society for the Promotion of Sciences","doi-asserted-by":"crossref","award":["18K19537"],"award-info":[{"award-number":["18K19537"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012833","name":"Niigata University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012833","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The etiology of non-alcoholic fatty liver disease (NAFLD) consists of various factors, including neural signal pathways. However, the molecular mechanisms of the autonomic neural signals influencing NAFLD progression have not been elucidated. Therefore, we examined the involvement of the gut-liver neural axis in NAFLD development and tested the therapeutic effect of modulation of this axis in this study. To test the contribution of the gut-liver neural axis, we examined NAFLD progression with respect to body weight, hepatic steatosis, fibrosis, intestinal tight junction, microbiota and short-chain fatty acids in NAFLD models of choline-deficient defined L-amino-acid and high-fat diet-fed mice with or without blockades of autonomic nerves from the liver. Blockade of the neural signal from the liver to the gut in these NAFLD mice models ameliorated the progression of liver weight, hepatic steatosis and fibrosis by modulating serotonin expression in the small intestine. It was related to the severity of the liver pathology, the tight junction protein expression, microbiota diversity and short-chain fatty acids. These effects were reproduced by administrating serotonin antagonist, which ameliorated the NAFLD progression in the NAFLD mice models. Our study demonstrated that the gut-liver neural axis is involved in the etiologies of NAFLD progression and that serotonin expression through this signaling network is the key factor of this axis. Therefore, modulation of the gut-liver neural axis and serotonin antagonist ameliorates fatty and fibrotic changes in non-alcoholic fatty liver, and can be a potential therapeutic target of NAFLD.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/dmm.048922","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T10:55:13Z","timestamp":1616928913000},"source":"Crossref","is-referenced-by-count":21,"title":["Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver"],"prefix":"10.1242","volume":"14","author":[{"given":"Masayoshi","family":"Ko","sequence":"first","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-4400","authenticated-orcid":false,"given":"Kenya","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"},{"name":"Niigata University School of Medicine 2 Department of General Medicine , , Niigata, 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-0388","authenticated-orcid":false,"given":"Takashi","family":"Owaki","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nagoya","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuo","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Niwa","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Shibata","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-640X","authenticated-orcid":false,"given":"Chiyumi","family":"Oda","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Setsu","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University, Niigata 1 Division of Gastroenterology and Hepatology , , 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"2023120111350042100_DMM048922C1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.intimp.2016.04.014","article-title":"Tropisetron suppresses colitis-associated cancer in a mouse model in the remission stage","volume":"36","author":"Amini-Khoei","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"2023120111350042100_DMM048922C2","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.pharep.2017.11.017","article-title":"Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: oxidative stress\/TGF-\u03b2 1-induced HSCs activation pathway","volume":"70","author":"Atallah","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"2023120111350042100_DMM048922C3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"2023120111350042100_DMM048922C4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fnins.2018.00049","article-title":"The vagus nerve at the interface of the microbiota-gut-brain axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"2023120111350042100_DMM048922C5","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/hep.28356","article-title":"The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota","volume":"63","author":"Boursier","year":"2016","journal-title":"Hepatology"},{"key":"2023120111350042100_DMM048922C6","doi-asserted-by":"publisher","first-page":"4824","DOI":"10.1038\/s41467-018-07287-7","article-title":"Serotonin signals through a gut-liver axis to regulate hepatic steatosis","volume":"9","author":"Choi","year":"2018","journal-title":"Nat. Commun."},{"key":"2023120111350042100_DMM048922C7","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1111\/ejn.14769","article-title":"Key role of 5-HT1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys","volume":"52","author":"Cinelli","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"2023120111350042100_DMM048922C8","doi-asserted-by":"publisher","first-page":"R122","DOI":"10.1152\/ajpregu.00264.2019","article-title":"Hypothalamic AMPK\u03b12 regulates liver energy metabolism in rainbow trout through vagal innervation","volume":"318","author":"Conde-Sieira","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2023120111350042100_DMM048922C9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"2023120111350042100_DMM048922C10","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3390\/cells8080845","article-title":"Current status in testing for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)","volume":"8","author":"Drescher","year":"2019","journal-title":"Cells"},{"key":"2023120111350042100_DMM048922C11","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2174\/1389201019666180528094202","article-title":"Intestinal crosstalk between microbiota and serotonin and its impact on gut motility","volume":"19","author":"Ge","year":"2018","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2023120111350042100_DMM048922C12","doi-asserted-by":"publisher","first-page":"7089","DOI":"10.1096\/fj.201902687R","article-title":"Western diet-induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis","volume":"34","author":"Gupta","year":"2020","journal-title":"FASEB J."},{"key":"2023120111350042100_DMM048922C13","doi-asserted-by":"publisher","first-page":"G335","DOI":"10.1152\/ajpgi.00088.2009","article-title":"Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice","volume":"298","author":"Haub","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2023120111350042100_DMM048922C14","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1124\/jpet.111.181834","article-title":"Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice","volume":"339","author":"Haub","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023120111350042100_DMM048922C15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"2023120111350042100_DMM048922C16","doi-asserted-by":"publisher","first-page":"e0227554","DOI":"10.1371\/journal.pone.0227554","article-title":"Serotonin transporter dependent modulation of food-seeking behavior","volume":"15","author":"He","year":"2020","journal-title":"PLoS ONE"},{"key":"2023120111350042100_DMM048922C17","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00535-019-01649-8","article-title":"Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives","volume":"55","author":"Hu","year":"2020","journal-title":"J. Gastroenterol."},{"key":"2023120111350042100_DMM048922C18","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1113\/JP277994","article-title":"Liver sympathetic denervation reverses obesity-induced hepatic steatosis","volume":"597","author":"Hurr","year":"2019","journal-title":"J. Physiol."},{"key":"2023120111350042100_DMM048922C19","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1126\/science.1163971","article-title":"Regulation of pancreatic beta cell mass by neuronal signals from the liver","volume":"322","author":"Imai","year":"2008","journal-title":"Science"},{"key":"2023120111350042100_DMM048922C20","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/2211-5463.12382","article-title":"Effect of a neural relay on liver regeneration in mice: activation of serotonin release from the gastrointestinal tract","volume":"8","author":"Inoue","year":"2018","journal-title":"FEBS Open Bio"},{"key":"2023120111350042100_DMM048922C21","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1038\/s41467-018-07747-0","article-title":"Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation","volume":"9","author":"Izumi","year":"2018","journal-title":"Nat. Commun."},{"key":"2023120111350042100_DMM048922C22","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.3748\/wjg.v24.i15.1616","article-title":"Autonomic nervous system network and liver regeneration","volume":"24","author":"Kamimura","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"2023120111350042100_DMM048922C23","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41593-019-0430-3","article-title":"Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression","volume":"22","author":"Kamiya","year":"2019","journal-title":"Nat. Neurosci."},{"key":"2023120111350042100_DMM048922C24","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/apt.15416","article-title":"Review article: can bugs be drugs? The potential of probiotics and prebiotics as treatment for non-alcoholic fatty liver disease","volume":"50","author":"Koopman","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2023120111350042100_DMM048922C25","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jcmgh.2019.01.004","article-title":"Modulation of gut microbiota composition by serotonin signaling influences intestinal immune response and susceptibility to colitis","volume":"7","author":"Kwon","year":"2019","journal-title":"Cell Mol. Gastroenterol Hepatol"},{"key":"2023120111350042100_DMM048922C26","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1002\/hep.30880","article-title":"Modulation of the tryptophan hydroxylase 1\/monoamine oxidase-A\/5-hydroxytryptamine\/5-hydroxytryptamine receptor 2A\/2B\/2C axis regulates biliary proliferation and liver fibrosis during cholestasis","volume":"71","author":"Kyritsi","year":"2020","journal-title":"Hepatology"},{"key":"2023120111350042100_DMM048922C27","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0016-5085(00)70373-8","article-title":"Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats","volume":"118","author":"Li","year":"2000","journal-title":"Gastroenterology"},{"key":"2023120111350042100_DMM048922C28","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.cmet.2017.04.001","article-title":"Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease","volume":"25","author":"Loomba","year":"2017","journal-title":"Cell Metab."},{"key":"2023120111350042100_DMM048922C29","doi-asserted-by":"publisher","first-page":"e13881","DOI":"10.1111\/nmo.13881","article-title":"Gut-brain axis serotonergic responses to acute stress exposure are microbiome-dependent","volume":"32","author":"Lyte","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"2023120111350042100_DMM048922C30","doi-asserted-by":"publisher","first-page":"e13869","DOI":"10.1111\/nmo.13869","article-title":"Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine","volume":"32","author":"Martin","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"2023120111350042100_DMM048922C31","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"2023120111350042100_DMM048922C32","doi-asserted-by":"publisher","first-page":"e84619","DOI":"10.1371\/journal.pone.0084619","article-title":"Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation","volume":"9","author":"Mikami","year":"2014","journal-title":"PLoS ONE"},{"key":"2023120111350042100_DMM048922C33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.12938\/bifidus.25.99","article-title":"Phylogenetic analysis of 16S ribosomal RNA gene sequences from human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling","volume":"25","author":"Nagashima","year":"2016","journal-title":"Biosci. Microflora."},{"key":"2023120111350042100_DMM048922C34","doi-asserted-by":"publisher","first-page":"e13799","DOI":"10.1111\/nmo.13799","article-title":"Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease","volume":"32","author":"Nagoya","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"2023120111350042100_DMM048922C35","doi-asserted-by":"publisher","first-page":"15426","DOI":"10.1074\/jbc.M117.788596","article-title":"Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4","volume":"292","author":"Nakata","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2023120111350042100_DMM048922C36","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4093\/dmj.2017.0084","article-title":"Inhibition of serotonin synthesis induces negative hepatic lipid balance","volume":"42","author":"Namkung","year":"2018","journal-title":"Diabetes Metab. J."},{"key":"2023120111350042100_DMM048922C37","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1053\/j.gastro.2016.06.022","article-title":"Loss of junctional adhesion molecule A promotes severe steatohepatitis in mice on a diet high in saturated fat, fructose, and cholesterol","volume":"151","author":"Rahman","year":"2016","journal-title":"Gastroenterology"},{"key":"2023120111350042100_DMM048922C38","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.autneu.2009.07.007","article-title":"Gut chemosensing: interactions between gut endocrine cells and visceral afferents","volume":"153","author":"Raybould","year":"2010","journal-title":"Auton. Neurosci."},{"key":"2023120111350042100_DMM048922C39","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/dev.21966","article-title":"Prenatal antidepressant exposures and gastrointestinal complaints in childhood: a gut-brain axis connection?","volume":"62","author":"Salisbury","year":"2020","journal-title":"Dev. Psychobiol."},{"key":"2023120111350042100_DMM048922C40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mimet.2013.04.002","article-title":"Comparison between terminal-restriction fragment length polymorphism (T-RFLP) and quantitative culture for analysis of infants\u2019 gut microbiota","volume":"94","author":"Sj\u00f6berg","year":"2013","journal-title":"J. Microbiol. Methods"},{"key":"2023120111350042100_DMM048922C41","doi-asserted-by":"publisher","first-page":"e13498","DOI":"10.1111\/nmo.13498","article-title":"Potentiation of serotonin signaling protects against intestinal ischemia and reperfusion injury in mice","volume":"31","author":"Tackett","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"2023120111350042100_DMM048922C42","doi-asserted-by":"publisher","first-page":"e105592","DOI":"10.1371\/journal.pone.0105592","article-title":"Development of a prokaryotic universal primer for simultaneous analysis of Bacteria and Archaea using next-generation sequencing","volume":"9","author":"Takahashi","year":"2014","journal-title":"PLoS One"},{"key":"2023120111350042100_DMM048922C43","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41586-020-2425-3","article-title":"The liver-brain-gut neural arc maintains the Treg cell niche in the gut","volume":"585","author":"Teratani","year":"2020","journal-title":"Nature"},{"key":"2023120111350042100_DMM048922C44","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/gutjnl-2019-320490","article-title":"Liver tissue microbiome in NAFLD: next step in understanding the gut-liver axis?","volume":"69","author":"Tilg","year":"2020","journal-title":"Gut"},{"key":"2023120111350042100_DMM048922C45","doi-asserted-by":"publisher","first-page":"G896","DOI":"10.1152\/ajpgi.00237.2017","article-title":"Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin","volume":"315","author":"Vincent","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2023120111350042100_DMM048922C46","first-page":"4995","article-title":"Image analysis of breast cancer immunohistochemistry-stained sections using ImageJ: an RGB-based model","volume":"29","author":"Vrekoussis","year":"2009","journal-title":"Anticancer Res."},{"key":"2023120111350042100_DMM048922C47","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1113\/jphysiol.2007.135996","article-title":"Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats","volume":"583","author":"Warne","year":"2007","journal-title":"J. Physiol."},{"key":"2023120111350042100_DMM048922C48","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.jhep.2017.05.007","article-title":"Targeting the gut-liver axis in liver disease","volume":"67","author":"Wiest","year":"2017","journal-title":"J. Hepatol."},{"key":"2023120111350042100_DMM048922C49","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"2023120111350042100_DMM048922C50","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nature12347","article-title":"Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome","volume":"499","author":"Yoshimoto","year":"2013","journal-title":"Nature"},{"key":"2023120111350042100_DMM048922C51","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dmm.048922","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.048922\/3259177\/dmm048922.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.048922\/3259177\/dmm048922.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T11:35:46Z","timestamp":1701430546000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/14\/3\/dmm048922\/237834\/Modulation-of-serotonin-in-the-gut-liver-neural"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.048922","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"article-number":"dmm048922"}}