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To investigate the genetic suitability of HSA as a model for AS, we sequenced \u223c1000 cancer genes in 41 cases of HSA and matched germline tissue: 15 canine visceral HSAs, 13 canine skin HSAs and 13 feline skin HSAs. Analysis of visceral HSAs from dogs presenting with concurrent splenic and cardiac neoplasms showed that the tumors were not independent primaries, consistent with the highly metastatic nature of HSA. Comparison of HSA to AS revealed that several driver genes were recurrently mutated in both species, such as TP53, PIK3CA, ATRX, GRIN2A and LRP1B. Similar to AS, a UV mutational signature was found in a subset of canine cutaneous HSAs and both species show differing mutational profiles between tissue sites. Our characterization of canine and feline HSA demonstrates many important parallels to AS and provides hope that future studies on these cancers will benefit of all three species.<\/jats:p>","DOI":"10.1242\/dmm.049044","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T07:43:40Z","timestamp":1624434220000},"source":"Crossref","is-referenced-by-count":40,"title":["Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma"],"prefix":"10.1242","volume":"14","author":[{"given":"Kim","family":"Wong","sequence":"first","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latasha","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, 50 Stone Road E., Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Krijgsman","sequence":"additional","affiliation":[{"name":"Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Adams","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Guelph, 50 Stone Road E., Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-1879","authenticated-orcid":false,"given":"Louise","family":"van der Weyden","sequence":"additional","affiliation":[{"name":"Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"2021072311181961600_DMM049044C1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/vco.12035","article-title":"Analysis of genomic mutation and immunohistochemistry of platelet-derived growth factor receptors in canine vascular tumours","volume":"13","author":"Abou Asa","year":"2015","journal-title":"Vet. 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