{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:23:27Z","timestamp":1787063007290,"version":"build-2736575974"},"reference-count":202,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases \u2013 bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, perinatal hypoxic\u2013ischemic encephalopathy and neonatal sepsis \u2013 and the available in vivo, in vitro and in silico preclinical models for studying these diseases. Better understanding of the strengths and weaknesses of specialized neonatal disease models will help to improve their utility, may add to the understanding of the mode of action and efficacy of a therapeutic, and\/or may improve the understanding of the disease pathology to aid in identification of new therapeutic targets. Although the diseases covered in this article are diverse and require specific approaches, several high-level, overarching key lessons can be learned by evaluating the strengths, weaknesses and gaps in the available models. This Review is intended to help guide current and future researchers toward successful development of therapeutics in these areas of high unmet medical need.<\/jats:p>","DOI":"10.1242\/dmm.049065","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T04:51:53Z","timestamp":1650862313000},"source":"Crossref","is-referenced-by-count":9,"title":["The benefits, limitations and opportunities of preclinical models for neonatal drug development"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-7718","authenticated-orcid":false,"given":"Sarah","family":"Campion","sequence":"first","affiliation":[{"name":"Pfizer Worldwide Research, Development, and Medical, Groton, CT 06340, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-7482","authenticated-orcid":false,"given":"Amy","family":"Inselman","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Hayes","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD 20993, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-5250","authenticated-orcid":false,"given":"Costanza","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology and Translational Science, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joseph","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD 20993, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology and Translational Science, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-3932","authenticated-orcid":false,"given":"Fabrizio","family":"Salomone","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology and Translational Science, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Pharma Research and Early Development, Roche Innovation Center Basel, Pharmaceutical Sciences, F. Hoffmann-La Roche, 4070 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hui","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb, Nonclinical Research and Development, Summit, NJ 07901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Davis-Bruno","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD 20993, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Van Malderen","sequence":"additional","affiliation":[{"name":"Federal Agency for Medicines and Health Products (FAMHP), Department DG PRE authorization, 1210 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaRonda","family":"Morford","sequence":"additional","affiliation":[{"name":"Eli Lilly, Global Regulatory Affairs, Indianapolis, IN 46285, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-7627","authenticated-orcid":false,"given":"Luc","family":"De Schaepdrijver","sequence":"additional","affiliation":[{"name":"Janssen R&D, Preclinical Sciences & Translational Safety, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Federal Institute for Drugs and Medical Devices, Clinical Trials, 53175 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-7072","authenticated-orcid":false,"given":"Stephanie","family":"Kourula","sequence":"additional","affiliation":[{"name":"Janssen R&D, Drug Metabolism & Pharmacokinetics, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Seo","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD 20993, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-7700","authenticated-orcid":false,"given":"Susan","family":"Laffan","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline, Non-Clinical Safety, Collegeville, PA 19406, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Urmaliya","sequence":"additional","affiliation":[{"name":"Janssen R&D, Discovery Sciences, 2340 Beerse, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Chen","sequence":"additional","affiliation":[{"name":"Health and Environmental Sciences Institute, Washington, DC 20005, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"2022042508513995600_DMM049065C1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jpeds.2017.02.061","article-title":"Two-year follow-up outcomes of premature infants enrolled in the Phase I trial of mesenchymal stem cells transplantation for bronchopulmonary dysplasia","volume":"185","author":"Ahn","year":"2017","journal-title":"J. Pediatr."},{"key":"2022042508513995600_DMM049065C2","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41467-019-09067-3","article-title":"Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour","volume":"10","author":"Akram","year":"2019","journal-title":"Nat. Commun."},{"key":"2022042508513995600_DMM049065C3","doi-asserted-by":"publisher","first-page":"L983","DOI":"10.1152\/ajplung.00178.2014","article-title":"Utility of large-animal models of BPD: chronically ventilated preterm lambs","volume":"308","author":"Albertine","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C4","doi-asserted-by":"publisher","first-page":"L213","DOI":"10.1152\/ajplung.00328.2015","article-title":"Ventilation-induced lung injury is not exacerbated by growth restriction in preterm lambs","volume":"310","author":"Allison","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C5","doi-asserted-by":"publisher","first-page":"9381","DOI":"10.1002\/jcb.28213","article-title":"RhoB antibody alters retinal vascularization in models of murine retinopathy","volume":"120","author":"Almonte-Baldonado","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"2022042508513995600_DMM049065C6","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12887-020-02231-5","article-title":"Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis","volume":"20","author":"Alsaied","year":"2020","journal-title":"BMC Pediatr."},{"key":"2022042508513995600_DMM049065C7","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/s41390-018-0228-0","article-title":"Preventing bronchopulmonary dysplasia: new tools for an old challenge","volume":"85","author":"Alvarez-Fuente","year":"2019","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1053\/j.semperi.2019.05.009","article-title":"Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity","volume":"43","author":"Aranda","year":"2019","journal-title":"Semin. Perinatol."},{"key":"2022042508513995600_DMM049065C9","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1007\/s11538-011-9631-y","article-title":"A continuum mathematical model of the developing murine retinal vasculature","volume":"73","author":"Aubert","year":"2011","journal-title":"Bull. Math. Biol."},{"key":"2022042508513995600_DMM049065C10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s13311-012-0108-y","article-title":"The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant","volume":"9","author":"Back","year":"2012","journal-title":"Neurotherapeutics"},{"key":"2022042508513995600_DMM049065C11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/0022-3468(74)90093-1","article-title":"An experimental study of acute neonatal enterocolitis--the importance of breast milk","volume":"9","author":"Barlow","year":"1974","journal-title":"J. Pediatr. Surg."},{"key":"2022042508513995600_DMM049065C12","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1056\/NEJMoa1501917","article-title":"Early inhaled budesonide for the prevention of bronchopulmonary dysplasia","volume":"373","author":"Bassler","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2022042508513995600_DMM049065C13","doi-asserted-by":"publisher","first-page":"660","DOI":"10.2460\/ajvr.2002.63.660","article-title":"Antimicrobial-induced endotoxin and cytokine activity in an in vitro model of septicemia in foals","volume":"63","author":"Bentley","year":"2002","journal-title":"Am. J. Vet. Res."},{"key":"2022042508513995600_DMM049065C14","doi-asserted-by":"publisher","first-page":"L936","DOI":"10.1152\/ajplung.00159.2014","article-title":"Animal models of bronchopulmonary dysplasia. The term mouse models","volume":"307","author":"Berger","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C15","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1542\/peds.2006-1088","article-title":"Genetic susceptibility to retinopathy of prematurity","volume":"118","author":"Bizzarro","year":"2006","journal-title":"Pediatrics"},{"key":"2022042508513995600_DMM049065C16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12974-019-1595-0","article-title":"Potential biomarkers for neuroinflammation and neurodegeneration at short and long term after neonatal hypoxic-ischemic insult in rat","volume":"16","author":"Borjini","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"2022042508513995600_DMM049065C17","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1128\/iai.22.2.480-485.1978","article-title":"Dynamics of Escherichia coli infection and meningitis in infant rats","volume":"22","author":"Bortolussi","year":"1978","journal-title":"Infect. Immun."},{"key":"2022042508513995600_DMM049065C18","doi-asserted-by":"publisher","DOI":"10.3791\/58574","article-title":"A controlled mouse model for neonatal polymicrobial sepsis","author":"Brook","year":"2019","journal-title":"JoVE"},{"key":"2022042508513995600_DMM049065C19","doi-asserted-by":"publisher","first-page":"e0218714","DOI":"10.1371\/journal.pone.0218714","article-title":"Robust health-score based survival prediction for a neonatal mouse model of polymicrobial sepsis","volume":"14","author":"Brook","year":"2019","journal-title":"PLoS ONE"},{"key":"2022042508513995600_DMM049065C198","first-page":"287","article-title":"Influence of a low atmospheric pressure on the development of the retinal vessels in the rat","volume":"71","author":"Campbell","year":"1951","journal-title":"Tr. Ophth. Soc. U. Kingdom"},{"key":"2022042508513995600_DMM049065C20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/prca.201300101","article-title":"The role of proteomics in understanding biological mechanisms of sepsis","volume":"8","author":"Cao","year":"2014","journal-title":"Proteomics Clin. Appl."},{"key":"2022042508513995600_DMM049065C21","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3109\/15513819409037698","article-title":"Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis","volume":"14","author":"Caplan","year":"1994","journal-title":"Pediatr Pathol."},{"key":"2022042508513995600_DMM049065C22","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1203\/00006450-199712000-00010","article-title":"The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis","volume":"42","author":"Caplan","year":"1997","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C23","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jpeds.2019.05.032","article-title":"Necrotizing enterocolitis: using regulatory science and drug development to improve outcomes","volume":"212","author":"Caplan","year":"2019","journal-title":"J. Pediatr."},{"key":"2022042508513995600_DMM049065C24","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1159\/000491859","article-title":"Melatonin acts in synergy with hypothermia to reduce oxygen-glucose deprivation-induced cell death in rat hippocampus organotypic slice cultures","volume":"114","author":"Carloni","year":"2018","journal-title":"Neonatology"},{"key":"2022042508513995600_DMM049065C25","first-page":"363","article-title":"Intestinal post-ischemic reperfusion injury: studies with neonatal necrotizing enterocolitis","volume":"73","author":"Cassutto","year":"1989","journal-title":"Acta Physiol. Hung."},{"key":"2022042508513995600_DMM049065C26","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.jpeds.2013.12.011","article-title":"Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial","volume":"164","author":"Chang","year":"2014","journal-title":"J. Pediatr."},{"key":"2022042508513995600_DMM049065C27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1076\/ceyr.24.4.281.8410","article-title":"Duration of acidosis and recovery determine preretinal neovascularization in the rat model of acidosis-induced retinopathy","volume":"24","author":"Chen","year":"2002","journal-title":"Curr. Eye Res."},{"key":"2022042508513995600_DMM049065C28","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1017\/erm.2016.13","article-title":"The immunological landscape in necrotising enterocolitis","volume":"18","author":"Cho","year":"2016","journal-title":"Expert Rev. Mol. Med."},{"key":"2022042508513995600_DMM049065C29","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/0022-3468(91)90716-7","article-title":"Necrotizing enterocolitis in a neonatal piglet model","volume":"26","author":"Cohen","year":"1991","journal-title":"J. Pediatr. Surg."},{"key":"2022042508513995600_DMM049065C30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1203\/PDR.0b013e31817307ac","article-title":"Effects of brief, clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen-induced retinopathy","volume":"64","author":"Coleman","year":"2008","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C31","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.pedneo.2015.09.007","article-title":"Early and late infections in newborns: where do we stand? A review","volume":"57","author":"Cortese","year":"2016","journal-title":"Pediatr. Neonatol."},{"key":"2022042508513995600_DMM049065C32","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/0016-5085(94)90012-4","article-title":"An animal model of necrotizing enterocolitis induced by infant formula and ischemia in developing piglets","volume":"106","author":"Crissinger","year":"1994","journal-title":"Gastroenterology"},{"key":"2022042508513995600_DMM049065C33","doi-asserted-by":"publisher","first-page":"L816","DOI":"10.1152\/ajplung.00249.2018","article-title":"Former-preterm lambs have persistent alveolar simplification at 2 and 5 months corrected postnatal age","volume":"315","author":"Dahl","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C34","doi-asserted-by":"publisher","first-page":"L210","DOI":"10.1152\/ajplung.00224.2012","article-title":"Reproducible uniform equibiaxial stretch of precision-cut lung slices","volume":"304","author":"Davidovich","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C35","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fneur.2015.00198","article-title":"Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy - where to from here?","volume":"6","author":"Davidson","year":"2015","journal-title":"Front. Neurol."},{"key":"2022042508513995600_DMM049065C36","doi-asserted-by":"publisher","first-page":"25178","DOI":"10.1038\/srep25178","article-title":"Extending the duration of hypothermia does not further improve white matter protection after ischemia in term-equivalent fetal sheep","volume":"6","author":"Davidson","year":"2016","journal-title":"Sci. Rep."},{"key":"2022042508513995600_DMM049065C37","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41390-019-0419-3","article-title":"The role of recombinant human CC10 in the prevention of chronic pulmonary insufficiency of prematurity","volume":"86","author":"Davis","year":"2019","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C38","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1053\/j.gastro.2015.12.042","article-title":"Organoid models of human gastrointestinal development and disease","volume":"150","author":"Dedhia","year":"2016","journal-title":"Gastroenterology"},{"key":"2022042508513995600_DMM049065C39","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol."},{"key":"2022042508513995600_DMM049065C40","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1203\/pdr.0b013e3180534219","article-title":"Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis","volume":"61","author":"De Plaen","year":"2007","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C41","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ijdevneu.2009.06.008","article-title":"Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test","volume":"27","author":"Derrick","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"key":"2022042508513995600_DMM049065C42","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.expneurol.2013.10.003","article-title":"Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep","volume":"250","author":"Drury","year":"2013","journal-title":"Exp. Neurol."},{"key":"2022042508513995600_DMM049065C43","doi-asserted-by":"publisher","first-page":"G156","DOI":"10.1152\/ajpgi.00196.2001","article-title":"Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model","volume":"282","author":"Dvorak","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2022042508513995600_DMM049065C44","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1203\/01.PDR.0000050657.56817.E0","article-title":"Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model","volume":"53","author":"Dvorak","year":"2003","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C45","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1128\/IAI.01235-12","article-title":"Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis","volume":"81","author":"Ernst","year":"2013","journal-title":"Infect. Immun."},{"key":"2022042508513995600_DMM049065C46","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.jpedsurg.2020.11.020","article-title":"Plasma citrulline during the first 48 h after onset of necrotizing enterocolitis in preterm infants","volume":"56","author":"Feenstra","year":"2021","journal-title":"J. Pediatr. Surg."},{"key":"2022042508513995600_DMM049065C47","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.jpedsurg.2005.12.020","article-title":"Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis","volume":"41","author":"Feng","year":"2006","journal-title":"J. Pediatr. Surg."},{"key":"2022042508513995600_DMM049065C48","first-page":"775","article-title":"Protein C preserves microcirculation in a model of neonatal septic shock","volume":"5","author":"Fischer","year":"2009","journal-title":"Vasc. Health Risk Manag."},{"key":"2022042508513995600_DMM049065C49","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/dmcn.12723","article-title":"Inflammation-induced sensitization of the brain in term infants","volume":"57","author":"Fleiss","year":"2015","journal-title":"Dev. Med. Child Neurol."},{"key":"2022042508513995600_DMM049065C50","first-page":"957","article-title":"Postnatal retinal vascular development of the puppy","volume":"26","author":"Flower","year":"1985","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2022042508513995600_DMM049065C51","author":"Food and Drug Administration","year":"2019"},{"key":"2022042508513995600_DMM049065C52","doi-asserted-by":"crossref","first-page":"628317","DOI":"10.5402\/2012\/628317","article-title":"What really causes necrotising enterocolitis?","volume":"2012","author":"Fox","year":"2012","journal-title":"ISRN Gastroenterol"},{"key":"2022042508513995600_DMM049065C53","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1053\/j.semperi.2008.01.001","article-title":"The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis","volume":"32","author":"Frost","year":"2008","journal-title":"Semin. Perinatol."},{"key":"2022042508513995600_DMM049065C54","doi-asserted-by":"publisher","first-page":"L949","DOI":"10.1152\/ajplung.00162.2020","article-title":"Intratracheal budesonide\/surfactant attenuates hyperoxia-induced lung injury in preterm rabbits","volume":"319","author":"Gie","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C55","doi-asserted-by":"publisher","first-page":"dmm047753","DOI":"10.1242\/dmm.047753","article-title":"Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies","volume":"14","author":"Giusto","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"2022042508513995600_DMM049065C56","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/jp.2010.193","article-title":"The age of necrotizing enterocolitis onset: an application of Sartwell's incubation period model","volume":"31","author":"Gonzalez-Rivera","year":"2011","journal-title":"J. Perinatol."},{"key":"2022042508513995600_DMM049065C57","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/pr.2012.134","article-title":"Endothelin receptor antagonist attenuates oxidative stress in a neonatal sepsis piglet model","volume":"72","author":"Goto","year":"2012","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C58","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.resuscitation.2015.03.026","article-title":"Animal studies of neonatal hypothermic neuroprotection have translated well in to practice","volume":"97","author":"Gunn","year":"2015","journal-title":"Resuscitation"},{"key":"2022042508513995600_DMM049065C59","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"2022042508513995600_DMM049065C60","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1203\/00006450-200206000-00012","article-title":"Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis","volume":"51","author":"Halpern","year":"2002","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C61","doi-asserted-by":"publisher","first-page":"G757","DOI":"10.1152\/ajpgi.00408.2005","article-title":"Reduction of experimental necrotizing enterocolitis with anti-TNF-alpha","volume":"290","author":"Halpern","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2022042508513995600_DMM049065C62","doi-asserted-by":"publisher","first-page":"G20","DOI":"10.1152\/ajpgi.00168.2007","article-title":"Decreased development of necrotizing enterocolitis in IL-18-deficient mice","volume":"294","author":"Halpern","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2022042508513995600_DMM049065C199","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2020.113457","article-title":"Animal models for neonatal brain injury induced by hypoxic ischemic conditions in rodents","volume":"334","author":"Hamdy","year":"2020","journal-title":"Exp. Neurol."},{"key":"2022042508513995600_DMM049065C63","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1177\/1933719116660846","article-title":"Potential role of prenatal inflammation in the impairment of lung development following mechanical ventilation of preterm lambs","volume":"24","author":"Hanita","year":"2017","journal-title":"Reprod. Sci."},{"key":"2022042508513995600_DMM049065C64","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1186\/scrt366","article-title":"Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems","volume":"4","author":"Hartman","year":"2013","journal-title":"Stem Cell Res Ther."},{"key":"2022042508513995600_DMM049065C65","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3928\/23258160-20190401-05","article-title":"Experimental evidence behind clinical trial outcomes in retinopathy of prematurity","volume":"50","author":"Hartnett","year":"2019","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"2022042508513995600_DMM049065C66","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/apa.13350","article-title":"Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development","volume":"105","author":"Hellstrom","year":"2016","journal-title":"Acta Paediatrica (Oslo, Norway: 1992)"},{"key":"2022042508513995600_DMM049065C67","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41390-020-01267-8","article-title":"Budesonide with surfactant decreases systemic responses in mechanically ventilated preterm lambs exposed to fetal intra-amniotic lipopolysaccharide","volume":"90","author":"Hillman","year":"2020","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C68","doi-asserted-by":"publisher","first-page":"L41","DOI":"10.1152\/ajplung.00203.2019","article-title":"Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep","volume":"318","author":"Hillman","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C69","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1080\/02713689808951233","article-title":"Carbon dioxide-induced retinopathy in the neonatal rat","volume":"17","author":"Holmes","year":"1998","journal-title":"Curr. Eye Res."},{"key":"2022042508513995600_DMM049065C70","first-page":"804","article-title":"Metabolic acidosis-induced retinopathy in the neonatal rat","volume":"40","author":"Holmes","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2022042508513995600_DMM049065C71","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1136\/bjo.2007.117283","article-title":"Genetic susceptibility to retinopathy of prematurity: the evidence from clinical and experimental animal studies","volume":"91","author":"Holmstrom","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"2022042508513995600_DMM049065C72","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1742-2094-11-87","article-title":"Neonatal systemic inflammation in rats alters retinal vessel development and simulates pathologic features of retinopathy of prematurity","volume":"11","author":"Hong","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"2022042508513995600_DMM049065C73","doi-asserted-by":"publisher","first-page":"647862","DOI":"10.1155\/2009\/647862","article-title":"Lactobacillus rhamnosus GG suppresses meningitic E. coli K1 penetration across human intestinal epithelial cells in vitro and protects neonatal rats against experimental hematogenous meningitis","volume":"2009","author":"Huang","year":"2009","journal-title":"Int. J. Microbiol."},{"key":"2022042508513995600_DMM049065C74","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neuroscience.2015.07.086","article-title":"Organotypic brain slice cultures: a review","volume":"305","author":"Humpel","year":"2015","journal-title":"Neuroscience"},{"key":"2022042508513995600_DMM049065C75","first-page":"5387","volume":"55","author":"Ifantides","year":"2014","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"2022042508513995600_DMM049065C76","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"2022042508513995600_DMM049065C77","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1055\/s-0040-1713406","article-title":"Plasma citrulline as a biomarker for early diagnosis of necrotizing enterocolitis in preterm infants","volume":"38","author":"Jawale","year":"2021","journal-title":"Am. J. Perinatol."},{"key":"2022042508513995600_DMM049065C78","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1203\/01.PDR.0000113463.70435.74","article-title":"Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis","volume":"55","author":"Jilling","year":"2004","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C79","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.4049\/jimmunol.177.5.3273","article-title":"The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis","volume":"177","author":"Jilling","year":"2006","journal-title":"J. Immunol."},{"key":"2022042508513995600_DMM049065C80","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","article-title":"Bronchopulmonary dysplasia","volume":"163","author":"Jobe","year":"2001","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2022042508513995600_DMM049065C81","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1046\/j.1365-2958.2000.02099.x","article-title":"Identification of Streptococcus agalactiae virulence genes in the neonatal rat sepsis model using signature-tagged mutagenesis","volume":"37","author":"Jones","year":"2000","journal-title":"Mol. Microbiol."},{"key":"2022042508513995600_DMM049065C82","doi-asserted-by":"publisher","first-page":"R1105","DOI":"10.1152\/ajpregu.00535.2005","article-title":"Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination","volume":"290","author":"Kanaan","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2022042508513995600_DMM049065C83","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1038\/s41598-018-21201-7","article-title":"Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids","volume":"8","author":"Kasendra","year":"2018","journal-title":"Sci. Rep."},{"key":"2022042508513995600_DMM049065C84","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.4049\/jimmunol.176.5.3181","article-title":". c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis","volume":"176","author":"Kenzel","year":"2006","journal-title":"J. Immunol."},{"key":"2022042508513995600_DMM049065C85","doi-asserted-by":"publisher","first-page":"G940","DOI":"10.1152\/ajpgi.00141.2009","article-title":"Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis","volume":"297","author":"Khailova","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2022042508513995600_DMM049065C86","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.micpath.2015.01.007","article-title":"Streptococcus agalactiae infection in zebrafish larvae","volume":"79","author":"Kim","year":"2015","journal-title":"Microb. Pathog."},{"key":"2022042508513995600_DMM049065C87","doi-asserted-by":"publisher","first-page":"2924848","DOI":"10.1155\/2017\/2924848","article-title":"Effects of poly(ADP-ribose) polymerase-1 inhibition in a neonatal rodent model of hypoxic-ischemic injury","volume":"2017","author":"Klofers","year":"2017","journal-title":"BioMed Res. Int."},{"key":"2022042508513995600_DMM049065C88","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1177\/0271678X18797328","article-title":"Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy","volume":"38","author":"Koehler","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2022042508513995600_DMM049065C89","doi-asserted-by":"publisher","first-page":"L193","DOI":"10.1152\/ajplung.00528.2017","article-title":"Effects of budesonide and surfactant in preterm fetal sheep","volume":"315","author":"Kothe","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C90","doi-asserted-by":"publisher","first-page":"L888","DOI":"10.1152\/ajplung.00477.2018","article-title":"Surfactant plus budesonide decreases lung and systemic inflammation in mechanically ventilated preterm sheep","volume":"316","author":"Kothe","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C91","doi-asserted-by":"publisher","first-page":"dmm044388","DOI":"10.1242\/dmm.044388","article-title":"Precision-based modeling approaches for necrotizing enterocolitis","volume":"13","author":"Kovler","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"2022042508513995600_DMM049065C92","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.4049\/jimmunol.179.7.4808","article-title":"A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair","volume":"179","author":"Leaphart","year":"2007","journal-title":"J. Immunol."},{"key":"2022042508513995600_DMM049065C93","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1177\/014860719902300502","article-title":"The ontogeny of the small intestinal epithelium","volume":"23","author":"Lebenthal","year":"1999","journal-title":"JPEN J. Parenter. Enteral. Nutr."},{"key":"2022042508513995600_DMM049065C94","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1128\/JB.01153-13","article-title":"The ssbL gene harbored by the ColV plasmid of an Escherichia coli neonatal meningitis strain is an auxiliary virulence factor boosting the production of siderophores through the shikimate pathway","volume":"196","author":"Lemaitre","year":"2014","journal-title":"J. Bacteriol."},{"key":"2022042508513995600_DMM049065C95","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/sur.2016.021","article-title":"Current murine models of sepsis","volume":"17","author":"Lewis","year":"2016","journal-title":"Surg. Infect. (Larchmt)"},{"key":"2022042508513995600_DMM049065C96","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/pr.2012.146","article-title":"Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety","volume":"73","author":"Ley","year":"2013","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C97","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1007\/s12035-015-9362-4","article-title":"Organotypic hippocampal slices as models for stroke and traumatic brain injury","volume":"53","author":"Li","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"2022042508513995600_DMM049065C98","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00383-018-4369-3","article-title":"Neonatal intestinal organoids as an ex vivo approach to study early intestinal epithelial disorders","volume":"35","author":"Li","year":"2019","journal-title":"Pediatr. Surg. Int."},{"key":"2022042508513995600_DMM049065C99","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1152\/japplphysiol.00300.2021","article-title":"Lung ultrasound features and relationships with respiratory mechanics of evolving BPD in preterm rabbits and human neonates","volume":"131","author":"Loi","year":"2021","journal-title":"J. Appl. Physiol. (1985)"},{"key":"2022042508513995600_DMM049065C100","doi-asserted-by":"publisher","first-page":"G917","DOI":"10.1152\/ajpgi.00422.2013","article-title":"Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges","volume":"306","author":"Lu","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2022042508513995600_DMM049065C101","doi-asserted-by":"crossref","first-page":"d1030","DOI":"10.2741\/1056","article-title":"Animal models of oxygen-induced retinopathy","volume":"8","author":"Madan","year":"2003","journal-title":"Front. Biosci."},{"key":"2022042508513995600_DMM049065C102","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1053\/j.gastro.2010.09.043","article-title":"TGF-beta2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine","volume":"140","author":"Maheshwari","year":"2011","journal-title":"Gastroenterology"},{"key":"2022042508513995600_DMM049065C103","doi-asserted-by":"publisher","first-page":"e95844","DOI":"10.1371\/journal.pone.0095844","article-title":"A hyperoxic lung injury model in premature rabbits: the influence of different gestational ages and oxygen concentrations","volume":"9","author":"Manzano","year":"2014","journal-title":"PLoS ONE"},{"key":"2022042508513995600_DMM049065C104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/2249-4847.128717","article-title":"Predicting disease severity of necrotizing enterocolitis: how to identify infants for future novel therapies","volume":"3","author":"Markel","year":"2014","journal-title":"J Clin Neonatol"},{"key":"2022042508513995600_DMM049065C200","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1007\/s11538-012-9754-9","article-title":"A hybrid discrete-continuum mathematical model of pattern prediction in the developing retinal vasculature","volume":"74","author":"McDougall","year":"2012","journal-title":"Bull. Math. Biol."},{"key":"2022042508513995600_DMM049065C105","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/01.PCC.0000165565.96773.08","article-title":"Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: effect of route of administration","volume":"6","author":"Miller","year":"2005","journal-title":"Pediatr. Crit. Care Med."},{"key":"2022042508513995600_DMM049065C106","first-page":"F424","article-title":"Proton magnetic resonance spectroscopy lactate\/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia","volume":"104","author":"Mitra","year":"2018","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed"},{"key":"2022042508513995600_DMM049065C107","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.prrv.2016.06.001","article-title":"Cell therapy for bronchopulmonary dysplasia: promises and perils","volume":"20","author":"Mobius","year":"2016","journal-title":"Paediatr. Respir. Rev."},{"key":"2022042508513995600_DMM049065C108","doi-asserted-by":"publisher","first-page":"G93","DOI":"10.1152\/ajpgi.00016.2012","article-title":"Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model","volume":"303","author":"MohanKumar","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2022042508513995600_DMM049065C109","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/pr.2016.189","article-title":"Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis","volume":"81","author":"MohanKumar","year":"2017","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C110","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/S0016-5085(99)70193-9","article-title":"Development of the human gastrointestinal tract: twenty years of progress","volume":"116","author":"Montgomery","year":"1999","journal-title":"Gastroenterology"},{"key":"2022042508513995600_DMM049065C111","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1053\/j.semperi.2018.09.001","article-title":"Recent advances in the pathogenesis of BPD","volume":"42","author":"Morty","year":"2018","journal-title":"Semin. Perinatol."},{"key":"2022042508513995600_DMM049065C112","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000506989","article-title":"Using experimental models to identify pathogenic pathways and putative disease management targets in bronchopulmonary dysplasia","volume":"117","author":"Morty","year":"2020","journal-title":"Neonatology"},{"key":"2022042508513995600_DMM049065C113","doi-asserted-by":"publisher","first-page":"4293279","DOI":"10.1155\/2021\/4293279","article-title":"Design-based stereology of the lung in the hyperoxic preterm rabbit model of bronchopulmonary dysplasia","volume":"2021","author":"Muhlfeld","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"2022042508513995600_DMM049065C114","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3109\/02713683.2011.611609","article-title":"Retinal function and morphology in rabbit after intravitreal injection of VEGF inhibitors","volume":"37","author":"Myers","year":"2012","journal-title":"Curr. Eye Res."},{"key":"2022042508513995600_DMM049065C115","first-page":"99","article-title":"Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates. Children (Basel","volume":"5","author":"Nair","year":"2018","journal-title":"Switzerland"},{"key":"2022042508513995600_DMM049065C116","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/jp.2016.108","article-title":"Impact of pulmonary hypertension on neurodevelopmental outcome in preterm infants with bronchopulmonary dysplasia: a cohort study","volume":"36","author":"Nakanishi","year":"2016","journal-title":"J. Perinatol."},{"key":"2022042508513995600_DMM049065C117","first-page":"185","article-title":"Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia","volume":"10","author":"Nardiello","year":"2017","journal-title":"Dis Model Mech"},{"key":"2022042508513995600_DMM049065C118","author":"National Eye Institute","year":"2019"},{"key":"2022042508513995600_DMM049065C119","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1159\/000365130","article-title":"Necrotizing enterocolitis: the mystery goes on","volume":"106","author":"Neu","year":"2014","journal-title":"Neonatology"},{"key":"2022042508513995600_DMM049065C120","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"Neu","year":"2011","journal-title":"New Engl. J. Med."},{"key":"2022042508513995600_DMM049065C121","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s40139-017-0137-7","article-title":"Lung organoids and their use to study cell-cell interaction","volume":"5","author":"Nikolic","year":"2017","journal-title":"Curr. Pathobiol. Reports"},{"key":"2022042508513995600_DMM049065C122","doi-asserted-by":"publisher","first-page":"e26575","DOI":"10.7554\/eLife.26575","article-title":"Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids","volume":"6","author":"Nikolic","year":"2017","journal-title":"eLife"},{"key":"2022042508513995600_DMM049065C123","doi-asserted-by":"publisher","first-page":"14384","DOI":"10.1073\/pnas.1306859110","article-title":"Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia","volume":"110","author":"Nold","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022042508513995600_DMM049065C124","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.clp.2018.01.015","article-title":"Perinatal brain injury: mechanisms, prevention, and outcomes","volume":"45","author":"Novak","year":"2018","journal-title":"Clin. Perinatol."},{"key":"2022042508513995600_DMM049065C125","doi-asserted-by":"publisher","first-page":"L948","DOI":"10.1152\/ajplung.00160.2014","article-title":"Animal models of bronchopulmonary dysplasia. The term rat models","volume":"307","author":"O'Reilly","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C126","doi-asserted-by":"publisher","first-page":"883","DOI":"10.3389\/fneur.2020.00883","article-title":"Proton magnetic resonance spectroscopy lactate\/N-acetylaspartate Within 48 h predicts cell death following varied neuroprotective interventions in a piglet model of hypoxia-ischemia with and without inflammation-sensitization","volume":"11","author":"Pang","year":"2020","journal-title":"Front. Neurol."},{"key":"2022042508513995600_DMM049065C127","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1042\/BST20130247","article-title":"Neonatal encephalopathy: pre-clinical studies in neuroprotection","volume":"42","author":"Patel","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"2022042508513995600_DMM049065C128","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2119\/molmed.2016.00188","article-title":"Development of a zebrafish sepsis model for high-throughput drug discovery","volume":"23","author":"Philip","year":"2017","journal-title":"Mol. Med."},{"key":"2022042508513995600_DMM049065C129","first-page":"Cd011932","article-title":"Mesenchymal stem cells for the prevention and treatment of bronchopulmonary dysplasia in preterm infants","volume":"11","author":"Pierro","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"2022042508513995600_DMM049065C130","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1203\/PDR.0b013e3181994a53","article-title":"Treatment of methicillin-resistant Staphylococcus aureus in neonatal mice: lysostaphin versus vancomycin","volume":"65","author":"Placencia","year":"2009","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C131","doi-asserted-by":"publisher","first-page":"F285","DOI":"10.1136\/archdischild-2017-314264","article-title":"Prevention of bronchopulmonary dysplasia in extremely low gestational age neonates: current evidence","volume":"103","author":"Poets","year":"2018","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"2022042508513995600_DMM049065C132","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1159\/000327241","article-title":"Involvement of neuronal nitric oxide synthase in ongoing fetal brain injury following near-term rabbit hypoxia-ischemia","volume":"33","author":"Rao","year":"2011","journal-title":"Dev. Neurosci."},{"key":"2022042508513995600_DMM049065C133","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1515\/jpm-2018-0360","article-title":"Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis","volume":"47","author":"Razak","year":"2019","journal-title":"J. Perinat. Med."},{"key":"2022042508513995600_DMM049065C134","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/1574884710666150929100210","article-title":"Pharmacokinetics of budesonide administered with surfactant in premature lambs: implications for neonatal clinical trials","volume":"11","author":"Roberts","year":"2016","journal-title":"Curr. Clin. Pharmacol."},{"key":"2022042508513995600_DMM049065C135","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2174\/157339631001140408120613","article-title":"Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications","volume":"10","author":"Robertson","year":"2014","journal-title":"Curr. Pediatr. Rev."},{"key":"2022042508513995600_DMM049065C136","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.nbd.2018.10.004","article-title":"Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: A translational study","volume":"121","author":"Robertson","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"2022042508513995600_DMM049065C137","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/infdis\/166.3.635","article-title":"Neonatal mouse model of group B streptococcal infection","volume":"166","author":"Rodewald","year":"1992","journal-title":"J. Infect. Dis."},{"key":"2022042508513995600_DMM049065C138","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1111\/jcmm.13044","article-title":"Refining anti-inflammatory therapy strategies for bronchopulmonary dysplasia","volume":"21","author":"Rudloff","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"2022042508513995600_DMM049065C139","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fneur.2016.00057","article-title":"Rodent hypoxia-ischemia models for cerebral palsy research: a systematic review","volume":"7","author":"Rumajogee","year":"2016","journal-title":"Front. Neurol."},{"key":"2022042508513995600_DMM049065C140","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1161\/STROKEAHA.112.674481","article-title":"Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats","volume":"43","author":"Sabir","year":"2012","journal-title":"Stroke"},{"key":"2022042508513995600_DMM049065C141","doi-asserted-by":"publisher","first-page":"e109845","DOI":"10.1371\/journal.pone.0109845","article-title":"Combined treatment of xenon and hypothermia in newborn rats--additive or synergistic effect?","volume":"9","author":"Sabir","year":"2014","journal-title":"PLoS ONE"},{"key":"2022042508513995600_DMM049065C142","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.2174\/1381612823666170926123550","article-title":"Modelling bronchopulmonary dysplasia in animals: arguments for the preterm rabbit model","volume":"23","author":"Salaets","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"2022042508513995600_DMM049065C143","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1177\/153537020623101106","article-title":"Gut responses to enteral nutrition in preterm infants and animals","volume":"231","author":"Sangild","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"2022042508513995600_DMM049065C144","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.2527\/jas.2013-6359","article-title":"Invited review: the preterm pig as a model in pediatric gastroenterology","volume":"91","author":"Sangild","year":"2013","journal-title":"J. Anim. Sci."},{"key":"2022042508513995600_DMM049065C201","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"2022042508513995600_DMM049065C145","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"2022042508513995600_DMM049065C146","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.braindev.2011.07.006","article-title":"Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation","volume":"34","author":"Schneider","year":"2012","journal-title":"Brain Dev."},{"key":"2022042508513995600_DMM049065C147","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/eye.2009.306","article-title":"Oxygen-induced retinopathy: a model for vascular pathology in the retina","volume":"24","author":"Scott","year":"2010","journal-title":"Eye"},{"key":"2022042508513995600_DMM049065C148","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1164\/rccm.201910-1975OC","article-title":"rhIGF-1\/BP3 preserves lung growth and prevents pulmonary hypertension in experimental bronchopulmonary dysplasia","volume":"201","author":"Seedorf","year":"2020","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2022042508513995600_DMM049065C149","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1128\/JB.188.6.2096-2105.2006","article-title":"Abundance of the delta subunit of RNA polymerase is linked to the virulence of Streptococcus agalactiae","volume":"188","author":"Seepersaud","year":"2006","journal-title":"J. Bacteriol."},{"key":"2022042508513995600_DMM049065C150","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1099\/mic.0.28516-0","article-title":"A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae. Microbiology (Reading","volume":"152","author":"Seifert","year":"2006","journal-title":"England"},{"key":"2022042508513995600_DMM049065C151","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.jcmgh.2018.01.014","article-title":"Human fetal-derived enterospheres provide insights on intestinal development and a novel model to study necrotizing enterocolitis (NEC)","volume":"5","author":"Senger","year":"2018","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"2022042508513995600_DMM049065C152","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.3389\/fnins.2019.01445","article-title":"A robust model system for retinal hypoxia: live imaging of calcium dynamics and gene expression studies in primary human mixed retinal culture","volume":"13","author":"Shahulhameed","year":"2019","journal-title":"Front. Neurosci."},{"key":"2022042508513995600_DMM049065C153","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/sj.jp.7211510","article-title":"Impact of gestational age on the clinical presentation and surgical outcome of necrotizing enterocolitis","volume":"26","author":"Sharma","year":"2006","journal-title":"J. Perinatol."},{"key":"2022042508513995600_DMM049065C154","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1177\/0192623318770379","article-title":"Gottingen minipigs in ocular research","volume":"46","author":"Shrader","year":"2018","journal-title":"Toxicol. Pathol."},{"key":"2022042508513995600_DMM049065C155","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/MOP.0000000000000463","article-title":"Challenges and opportunities to enhance global drug development in neonates","volume":"29","author":"Smith","year":"2017","journal-title":"Curr. Opin. Pediatr."},{"key":"2022042508513995600_DMM049065C156","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1242\/dmm.000315","article-title":"The development of animal models for the study of necrotizing enterocolitis","volume":"1","author":"Sodhi","year":"2008","journal-title":"Dis. Model. Mech."},{"key":"2022042508513995600_DMM049065C157","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jcmgh.2017.11.003","article-title":"Taming the wild west of organoids, enteroids, and mini-guts","volume":"5","author":"Spence","year":"2018","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"2022042508513995600_DMM049065C158","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","article-title":"Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network","volume":"126","author":"Stoll","year":"2010","journal-title":"Pediatrics"},{"key":"2022042508513995600_DMM049065C159","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1001\/jama.2015.10244","article-title":"Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012","volume":"314","author":"Stoll","year":"2015","journal-title":"JAMA"},{"key":"2022042508513995600_DMM049065C160","doi-asserted-by":"publisher","first-page":"L889","DOI":"10.1152\/ajplung.00446.2015","article-title":"A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology","volume":"310","author":"Sucre","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C161","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.ajpath.2017.12.004","article-title":"A shared pattern of beta-catenin activation in bronchopulmonary dysplasia and idiopathic pulmonary fibrosis","volume":"188","author":"Sucre","year":"2018","journal-title":"Am. J. Pathol."},{"key":"2022042508513995600_DMM049065C162","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1165\/rcmb.2017-0442MA","article-title":"Successful establishment of primary type II alveolar epithelium with 3D organotypic coculture","volume":"59","author":"Sucre","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2022042508513995600_DMM049065C163","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1164\/rccm.201908-1513OC","article-title":"hyperoxia injury in the developing lung is mediated by mesenchymal expression of Wnt5A","volume":"201","author":"Sucre","year":"2020","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2022042508513995600_DMM049065C164","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/BF02064356","article-title":"Endotoxin-resistant mice are protected from PAF-induced bowel injury and death. Role of TNF, complement activation, and endogenous PAF production","volume":"40","author":"Sun","year":"1995","journal-title":"Dig. Dis. Sci."},{"key":"2022042508513995600_DMM049065C165","doi-asserted-by":"publisher","first-page":"955","DOI":"10.3791\/955","article-title":"The hypoxic-ischemic encephalopathy model of perinatal ischemia","author":"Taniguchi","year":"2008","journal-title":"JoVE"},{"key":"2022042508513995600_DMM049065C166","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ajpath.2014.08.028","article-title":"Pathogenesis of necrotizing enterocolitis: modeling the innate immune response","volume":"185","author":"Tanner","year":"2015","journal-title":"Am. J. Pathol."},{"key":"2022042508513995600_DMM049065C167","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","article-title":"A piglet survival model of posthypoxic encephalopathy","volume":"40","author":"Thoresen","year":"1996","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C168","doi-asserted-by":"publisher","first-page":"14","DOI":"10.47338\/jns.v4.167","article-title":"Spontaneous intestinal perforation in neonates","volume":"4","author":"Tiwari","year":"2015","journal-title":"J. Neonatal. Surg."},{"key":"2022042508513995600_DMM049065C169","doi-asserted-by":"publisher","first-page":"e83304","DOI":"10.1371\/journal.pone.0083304","article-title":"Intestinal microbial ecology and environmental factors affecting necrotizing enterocolitis","volume":"8","author":"Torrazza","year":"2013","journal-title":"PLoS ONE"},{"key":"2022042508513995600_DMM049065C170","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1159\/000355460","article-title":"Concurrent erythropoietin and hypothermia treatment improve outcomes in a term nonhuman primate model of perinatal asphyxia","volume":"35","author":"Traudt","year":"2013","journal-title":"Dev. Neurosci."},{"key":"2022042508513995600_DMM049065C171","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0014-4835(73)90149-8","article-title":"Effect of oxygen on the developing retinal vessels of the rabbit. 3. Mode of growth of rabbit retinal vessels in tissue culture","volume":"15","author":"Tripathi","year":"1973","journal-title":"Exp. Eye Res."},{"key":"2022042508513995600_DMM049065C202","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.expneurol.2013.04.015","article-title":"A novel reproducible model of neonatal stroke in mice: Comparison with a hypoxia-ischemia model","volume":"247","author":"Tsuji","year":"2013","journal-title":"Exp. Neurol."},{"key":"2022042508513995600_DMM049065C172","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.brainresrev.2008.04.007","article-title":"Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia\/ischemia","volume":"59","author":"van der Kooij","year":"2008","journal-title":"Brain Res. Rev."},{"key":"2022042508513995600_DMM049065C173","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000085978","article-title":"Perinatal hypoxic-ischemic brain damage: evolution of an animal model","volume":"27","author":"Vannucci","year":"2005","journal-title":"Dev. Neurosci."},{"key":"2022042508513995600_DMM049065C174","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/BF02877698","article-title":"Prophylaxis with lactoferrin, a novel antimicrobial agent, in a neonatal rat model of coinfection","volume":"24","author":"Venkatesh","year":"2007","journal-title":"Adv. Ther."},{"key":"2022042508513995600_DMM049065C175","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.clp.2010.02.002","article-title":"Group B streptococcal disease in infants: progress in prevention and continued challenges","volume":"37","author":"Verani","year":"2010","journal-title":"Clin. Perinatol."},{"key":"2022042508513995600_DMM049065C176","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1177\/0300985820954551","article-title":"Neonatal and juvenile ocular development in gottingen minipigs and domestic pigs: a histomorphological and immunohistochemical study","volume":"57","author":"Vrolyk","year":"2020","journal-title":"Vet. Pathol."},{"key":"2022042508513995600_DMM049065C177","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1038\/ismej.2009.37","article-title":"16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis","volume":"3","author":"Wang","year":"2009","journal-title":"ISME J."},{"key":"2022042508513995600_DMM049065C178","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1002\/emmm.201201375","article-title":"New approaches to the study of sepsis","volume":"4","author":"Ward","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"2022042508513995600_DMM049065C179","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1098\/rsif.2012.0067","article-title":"Dynamics of angiogenesis during murine retinal development: a coupled in vivo and in silico study","volume":"9","author":"Watson","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"2022042508513995600_DMM049065C180","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/pr.2012.115","article-title":"Appropriate antibiotic therapy improves Ureaplasma sepsis outcome in the neonatal mouse","volume":"72","author":"Weisman","year":"2012","journal-title":"Pediatr. Res."},{"key":"2022042508513995600_DMM049065C181","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/gutjnl-2011-301551","article-title":"Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)\/effector (CD4, CD8) T cell ratios","volume":"62","author":"Weitkamp","year":"2013","journal-title":"Gut"},{"key":"2022042508513995600_DMM049065C182","doi-asserted-by":"publisher","first-page":"F291","DOI":"10.1152\/ajprenal.00328.2017","article-title":"A zebrafish model of infection-associated acute kidney injury","volume":"315","author":"Wen","year":"2018","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"2022042508513995600_DMM049065C183","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.jcmgh.2019.11.002","article-title":"A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis","volume":"9","author":"Werts","year":"2020","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"2022042508513995600_DMM049065C184","first-page":"727","article-title":"Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling","volume":"10","author":"White","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2022042508513995600_DMM049065C185","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1055\/s-0028-1090587","article-title":"Recombinant human Clara cell secretory protein treatment increases lung mRNA expression of surfactant proteins and vascular endothelial growth factor in a premature lamb model of respiratory distress syndrome","volume":"25","author":"Wolfson","year":"2008","journal-title":"Am. J. Perinatol."},{"key":"2022042508513995600_DMM049065C186","doi-asserted-by":"crossref","first-page":"e0126750","DOI":"10.1371\/journal.pone.0126750","article-title":"Hypoxia-induced retinal neovascularization in zebrafish embryos: a potential model of retinopathy of prematurity","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS ONE"},{"key":"2022042508513995600_DMM049065C187","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/shk.0b013e3180556d09","article-title":"Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock (Augusta","volume":"28","author":"Wynn","year":"2007","journal-title":"Ga"},{"key":"2022042508513995600_DMM049065C188","first-page":"99","article-title":"Animal models for retinal diseases","volume-title":"Neuromethods","author":"Yanni","year":"2010"},{"key":"2022042508513995600_DMM049065C189","doi-asserted-by":"publisher","first-page":"e1310","DOI":"10.1542\/peds.2007-1973","article-title":"Early intratracheal instillation of budesonide using surfactant as a vehicle to prevent chronic lung disease in preterm infants: a pilot study","volume":"121","author":"Yeh","year":"2008","journal-title":"Pediatrics"},{"key":"2022042508513995600_DMM049065C190","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1164\/rccm.201505-0861OC","article-title":"Intratracheal administration of budesonide\/surfactant to prevent bronchopulmonary dysplasia","volume":"193","author":"Yeh","year":"2016","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"2022042508513995600_DMM049065C191","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1080\/14737175.2017.1259567","article-title":"Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment","volume":"17","author":"Yildiz","year":"2017","journal-title":"Expert Rev. Neurother"},{"key":"2022042508513995600_DMM049065C192","doi-asserted-by":"publisher","first-page":"L970","DOI":"10.1152\/ajplung.00171.2014","article-title":"Animal models of bronchopulmonary dysplasia. The preterm baboon models","volume":"307","author":"Yoder","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2022042508513995600_DMM049065C193","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1051\/rnd:19990101","article-title":"Development of gastrointestinal and pancreatic functions in mammalians (mainly bovine and porcine species): influence of age and ingested food","volume":"39","author":"Zabielski","year":"1999","journal-title":"Reprod. Nutr. Dev."},{"key":"2022042508513995600_DMM049065C194","first-page":"522","article-title":"Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice","volume":"5","author":"Zhang","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"2022042508513995600_DMM049065C195","first-page":"1066","article-title":"Preretinal neovascularization associated with acetazolamide-induced systemic acidosis in the neonatal rat","volume":"42","author":"Zhang","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2022042508513995600_DMM049065C196","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fped.2020.00271","article-title":"An innovative model of bronchopulmonary dysplasia in premature infants","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Pediatr."},{"key":"2022042508513995600_DMM049065C197","first-page":"1445","article-title":"Establishment of the vascular injury model of retinopathy of prematurity in vitro","volume-title":"EAP 2017 Congress and MasterCourse","author":"Zhu","year":"2017"}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049065\/2141011\/dmm049065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049065\/2141011\/dmm049065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T04:52:09Z","timestamp":1650862329000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/15\/4\/dmm049065\/275112\/The-benefits-limitations-and-opportunities-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":202,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.049065","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]},"article-number":"dmm049065"}}