{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:16Z","timestamp":1790775256288,"version":"4.1.0"},"reference-count":225,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Cancer Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS\/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous syndrome, Costello syndrome and Legius syndrome, among others, have overlapping clinical features due to RAS\/MAPK dysfunction. Although several of the RASopathies are very rare, collectively, these disorders are relatively common. In this Review, we discuss the pathogenesis of the RASopathy-associated genetic variants and the knowledge gained about RAS\/MAPK signaling that resulted from studying RASopathies. We also describe the cell and animal models of the RASopathies and explore emerging RASopathy genes. Preclinical and clinical experiences with targeted agents as therapeutics for RASopathies are also discussed. Finally, we review how the recently developed drugs targeting RAS\/MAPK-driven malignancies, such as inhibitors of RAS activation, direct RAS inhibitors and RAS\/MAPK pathway inhibitors, might be leveraged for patients with RASopathies.<\/jats:p>","DOI":"10.1242\/dmm.049107","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T07:45:18Z","timestamp":1645170318000},"source":"Crossref","is-referenced-by-count":150,"title":["The RASopathies: from pathogenetics to therapeutics"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-8930","authenticated-orcid":false,"given":"Katie E.","family":"Hebron","sequence":"first","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute Pediatric Oncology Branch , , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edjay Ralph","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute Pediatric Oncology Branch , , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-9426","authenticated-orcid":false,"given":"Marielle E.","family":"Yohe","sequence":"additional","affiliation":[{"name":"Center for Cancer Research, National Cancer Institute Pediatric Oncology Branch , , Bethesda, MD 20892 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"2024061306453265000_DMM049107C1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/ajmg.a.35292","article-title":"Prevalence and clinical features of Costello syndrome and cardio-facio-cutaneous syndrome in Japan: findings from a nationwide epidemiological survey","volume":"158A","author":"Abe","year":"2012","journal-title":"Am. 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