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Here, we summarise transcriptome analyses of young adult (pre-disease) brains from a collection of 11 early-onset familial Alzheimer's disease (EOFAD)-like and non-EOFAD-like mutations in three zebrafish genes. The one cellular activity consistently predicted as affected by only the EOFAD-like mutations is oxidative phosphorylation, which produces most of the energy of the brain. All the mutations were predicted to affect protein synthesis. We extended our analysis to knock-in mouse models of APOE alleles and found the same effect for the late onset Alzheimer's disease risk allele \u03b54. Our results support a common molecular basis for the initiation of the pathological processes leading to both early and late onset forms of Alzheimer's disease, and illustrate the utility of zebrafish and knock-in single EOFAD mutation models for understanding the causes of this disease.<\/jats:p>","DOI":"10.1242\/dmm.049187","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T11:02:43Z","timestamp":1638183763000},"source":"Crossref","is-referenced-by-count":13,"title":["Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4693-8833","authenticated-orcid":false,"given":"Karissa","family":"Barthelson","sequence":"first","affiliation":[{"name":"Alzheimer's Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-4529","authenticated-orcid":false,"given":"Morgan","family":"Newman","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-444X","authenticated-orcid":false,"given":"Michael","family":"Lardelli","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"2022012613454182100_DMM049187C1","first-page":"1134","article-title":"\u00dcber einen eigenartigen schweren erkrankungsproze\u03b2 der hirnrincle","volume":"25","author":"Alzheimer","year":"1906","journal-title":"Neurol Cent."},{"key":"2022012613454182100_DMM049187C2","doi-asserted-by":"publisher","first-page":"13461","DOI":"10.1073\/pnas.0503689102","article-title":"Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein","volume":"102","author":"Andersen","year":"2005","journal-title":"Proc. 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