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Genetic surveys of host susceptibilities to such infections using mammalian models have certain disadvantages in that obtaining results is time-consuming, owing to relatively long lifespans, and these results have low statistical resolution because sample sizes are usually small. Here, we report a targeted genetic screening of 5698 RNAi lines encompassing 4135 Drosophila genes with human homologues, several of which we identify as important for host survival after Candida albicans infection. These include genes in a variety of functional classes encompassing gene expression, intracellular signalling, metabolism and enzymatic regulation. Analysis of one of the screen hits, the infection-induced \u03b1-(1,3)-fucosylase FucTA, showed that N-glycan fucosylation has several targets among proteins involved in host defence, which provides multiple avenues of investigation for the mechanistic analysis of host survival to systemic C. albicans infection.<\/jats:p>","DOI":"10.1242\/dmm.049218","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T10:36:12Z","timestamp":1644489372000},"source":"Crossref","is-referenced-by-count":6,"title":["A genetic screen in<i>Drosophila<\/i>reveals the role of fucosylation in host susceptibility to<i>Candida<\/i>infection"],"prefix":"10.1242","volume":"15","author":[{"given":"Marcus T.","family":"Glittenberg","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"},{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-0457","authenticated-orcid":false,"given":"Ilias","family":"Kounatidis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"},{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-2023","authenticated-orcid":false,"given":"Magda","family":"Atilano","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"},{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-9993","authenticated-orcid":false,"given":"Petros","family":"Ligoxygakis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"},{"name":"Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"2022050908483988200_DMM049218C1","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1074\/jbc.M412106200","article-title":"Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila","volume":"280","author":"Auluck","year":"2005","journal-title":"J. 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