{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:59:09Z","timestamp":1770461949120,"version":"3.49.0"},"reference-count":107,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Netherlands Food and Consumer Product Safety Authority"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Exposure to cigarette smoke (CS) is the primary risk factor for developing chronic obstructive pulmonary disease. The impact of CS exposure on the molecular mechanisms involved in mitochondrial quality control in airway epithelial cells is incompletely understood. Undifferentiated or differentiated primary bronchial epithelial cells were acutely\/chronically exposed to whole CS (WCS) or CS extract (CSE) in submerged or air\u2013liquid interface conditions. Abundance of key regulators controlling mitochondrial biogenesis, mitophagy and mitochondrial dynamics was assessed. Acute exposure to WCS or CSE increased the abundance of components of autophagy and receptor-mediated mitophagy in all models. Although mitochondrial content and dynamics appeared to be unaltered in response to CS, changes in both the molecular control of mitochondrial biogenesis and a shift toward an increased glycolytic metabolism were observed in particular in differentiated cultures. These alterations persisted, at least in part, after chronic exposure to WCS during differentiation and upon subsequent discontinuation of WCS exposure. In conclusion, smoke exposure alters the regulation of mitochondrial metabolism in airway epithelial cells, but observed alterations may differ between various culture models used.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the joint first authors of the paper.<\/jats:p>","DOI":"10.1242\/dmm.049247","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T13:34:33Z","timestamp":1648474473000},"source":"Crossref","is-referenced-by-count":22,"title":["Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-3036","authenticated-orcid":false,"given":"Christy B. M.","family":"Tulen","sequence":"first","affiliation":[{"name":"School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ 1 Department of Pharmacology and Toxicology , , PO Box 616, 6200 MD Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center 2 Department of Pulmonology , , PO Box 9600, 2300 RC Leiden , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan","family":"Beentjes","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center 2 Department of Pulmonology , , PO Box 9600, 2300 RC Leiden , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis J. J.","family":"Jessen","sequence":"additional","affiliation":[{"name":"School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ 1 Department of Pharmacology and Toxicology , , PO Box 616, 6200 MD Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis K.","family":"Ninaber","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center 2 Department of Pulmonology , , PO Box 9600, 2300 RC Leiden , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki L.","family":"Reynaert","sequence":"additional","affiliation":[{"name":"School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ 3 Department of Respiratory Medicine , , PO Box 616, 6200 MD Maastricht , The Netherlands"},{"name":"Maastricht University Medical Center+ 4 Primary Lung Culture Facility , , PO Box 616, 6200 MD Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik-Jan","family":"van Schooten","sequence":"additional","affiliation":[{"name":"School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ 1 Department of Pharmacology and Toxicology , , PO Box 616, 6200 MD Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoon","family":"Opperhuizen","sequence":"additional","affiliation":[{"name":"School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+ 1 Department of Pharmacology and Toxicology , , PO Box 616, 6200 MD Maastricht , The Netherlands"},{"name":"Office of Risk Assessment and Research, Netherlands Food and Consumer Product Safety Authority 5 , PO Box 8433, 3503 RK Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter S.","family":"Hiemstra","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center 2 Department of Pulmonology , , PO Box 9600, 2300 RC Leiden , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander H. 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