{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:59:57Z","timestamp":1791874797583,"version":"4.3.4"},"reference-count":161,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Human Frontier Science Program","award":["LT000937\/2016"],"award-info":[{"award-number":["LT000937\/2016"]}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cachexia, a wasting syndrome that is often associated with cancer, is one of the primary causes of death in cancer patients. Cancer cachexia occurs largely due to systemic metabolic alterations stimulated by tumors. Despite the prevalence of cachexia, our understanding of how tumors interact with host tissues and how they affect metabolism is limited. Among the challenges of studying tumor\u2013host tissue crosstalk are the complexity of cancer itself and our insufficient knowledge of the factors that tumors release into the blood. Drosophila is emerging as a powerful model in which to identify tumor-derived factors that influence systemic metabolism and tissue wasting. Strikingly, studies that are characterizing factors derived from different fly tumor cachexia models are identifying both common and distinct cachectic molecules, suggesting that cachexia is more than one disease and that fly models can help identify these differences. Here, we review what has been learned from studies of tumor-induced organ wasting in Drosophila and discuss the open questions.<\/jats:p>","DOI":"10.1242\/dmm.049298","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T09:15:01Z","timestamp":1648026901000},"source":"Crossref","is-referenced-by-count":55,"title":["Cancer cachexia: lessons from\n                    <i>Drosophila<\/i>"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-1980","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-472X","authenticated-orcid":false,"given":"Norbert","family":"Perrimon","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA"},{"name":"Howard Hughes Medical Institute, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"2022032914242423500_DMM049298C1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2016.03.003","article-title":"The Drosophila TNF Eiger is an adipokine that acts on insulin-producing cells to mediate nutrient response","volume":"23","author":"Agrawal","year":"2016","journal-title":"Cell Metab."},{"key":"2022032914242423500_DMM049298C2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.semcdb.2014.03.023","article-title":"JAK\/STAT pathway dysregulation in tumors: a Drosophila perspective","volume":"28","author":"Amoyel","year":"2014","journal-title":"Semin. 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