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JNK signalling gene variants are associated with schizophrenia risk, and JNK modulates aspects of cognition. We therefore studied the performance of mice hemizygous for genetic deletion of the JNK activator MKK7 (Map2k7+\/\u2212 mice) in a touchscreen version of the Iowa gambling task, additionally incorporating a novel contingency-switching stage. Map2k7+\/\u2212 mice performed slightly better than wild-type (WT) littermates in acquisition and performance of the task. Although Map2k7+\/\u2212 mice adapted well to subtle changes in risk\/reward contingencies, they were profoundly impaired when the positions of \u2018best\u2019 and \u2018worst\u2019 choice selections were switched, and still avoided the previous \u2018worst\u2019 choice location weeks after the switch. This demonstrates a precise role for MKK7\u2013JNK signalling in flexibility of risk\/reward assessment and suggests that genetic variants affecting this molecular pathway may underlie impairment in this cognitive domain in schizophrenia. Importantly, this new contingency shift adaptation of the rodent touchscreen gambling task has translational utility for characterising these cognitive subprocesses in models of neuropsychiatric disorders.<\/jats:p>","DOI":"10.1242\/dmm.049310","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T14:42:23Z","timestamp":1647009743000},"source":"Crossref","is-referenced-by-count":11,"title":["The schizophrenia risk gene <i>Map2k7<\/i> regulates responding in a novel contingency-shifting rodent touchscreen gambling task"],"prefix":"10.1242","volume":"15","author":[{"given":"Rebecca L.","family":"Openshaw","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-0795","authenticated-orcid":false,"given":"Brian J.","family":"Morris","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"2022031114421615900_DMM049310C1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.psychres.2004.04.013","article-title":"Deficit in decision making in catatonic schizophrenia: an exploratory study","volume":"134","author":"Bark","year":"2005","journal-title":"Psychiatry Res."},{"key":"2022031114421615900_DMM049310C2","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.neuropharm.2011.08.023","article-title":"Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method","volume":"61","author":"Bartko","year":"2011","journal-title":"Neuropharmacology"},{"key":"2022031114421615900_DMM049310C3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0010-0277(94)90018-3","article-title":"Insensitivity to future consequences following damage to human prefrontal cortex","volume":"50","author":"Bechara","year":"1994","journal-title":"Cognition"},{"key":"2022031114421615900_DMM049310C4","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0005-7967(92)90007-4","article-title":"Attention and memory for threat in panic disorder","volume":"30","author":"Beck","year":"1992","journal-title":"Behav. 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