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However, as neurofibromin is a large cytoplasmic protein the RAS regulatory domain of which occupies only 10% of its entire coding sequence, both canonical and non-canonical RAS pathway modulation, as well as the existence of potential non-RAS functions, are becoming apparent. In this Special article, we discuss our current understanding of neurofibromin function.<\/jats:p>","DOI":"10.1242\/dmm.049362","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T04:46:17Z","timestamp":1645418777000},"source":"Crossref","is-referenced-by-count":84,"title":["RAS and beyond: the many faces of the neurofibromatosis type 1 protein"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-6488","authenticated-orcid":false,"given":"Corina","family":"Anastasaki","sequence":"first","affiliation":[{"name":"Washington University School of Medicine Department of Neurology , , St Louis , MO 63110 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Orozco","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine Department of Neurology , , St Louis , MO 63110 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-5045","authenticated-orcid":false,"given":"David H.","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine Department of Neurology , , St Louis , MO 63110 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"2024061306453199400_DMM049362C1","doi-asserted-by":"publisher","first-page":"6712","DOI":"10.1093\/hmg\/ddu389","article-title":"Neuronal NF1\/RAS regulation of cyclic AMP requires atypical PKC activation","volume":"23","author":"Anastasaki","year":"2014","journal-title":"Hum. 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