{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:00:52Z","timestamp":1793059252471,"version":"4.5.0"},"reference-count":66,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["BR 5143\/5-1"],"award-info":[{"award-number":["BR 5143\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The uterus is responsible for the nourishment and mechanical protection of the developing embryo and fetus and is an essential part in mammalian reproduction. Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser (MRKH) syndrome is characterized by agenesis of the uterus and upper part of the vagina in females with normal ovarian function. Although heavily studied, the cause of the disease is still enigmatic. Current research in the field of MRKH mainly focuses on DNA-sequencing efforts and, so far, has been unable to decipher the nature and heterogeneity of the disease, thereby holding back scientific and clinical progress. Here, we developed long-term expandable organoid cultures from endometrium found in uterine rudiment horns of MRKH patients. Phenotypically, they share great similarity with healthy control organoids and are surprisingly fully hormone responsive. Transcriptome analyses, however, identified an array of dysregulated genes that point to potentially disease-causing pathways altered during the development of the female reproductive tract. We consider the endometrial organoid cultures to be a powerful research tool that promise to enable an array of studies into the pathogenic origins of MRKH syndrome and possible treatment opportunities to improve patient quality of life.<\/jats:p>","DOI":"10.1242\/dmm.049379","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T07:57:03Z","timestamp":1649404623000},"source":"Crossref","is-referenced-by-count":18,"title":["Endometrial organoids derived from Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser syndrome patients provide insights into disease-causing pathways"],"prefix":"10.1242","volume":"15","author":[{"given":"Sara Y.","family":"Brucker","sequence":"first","affiliation":[{"name":"University of T\u00fcbingen, 72076 T\u00fcbingen 1 Department of Women's Health , , Germany"},{"name":"Rare Disease Center T\u00fcbingen, University of T\u00fcbingen, 72076 T\u00fcbingen 2 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1488-9096","authenticated-orcid":false,"given":"Thomas","family":"Hentrich","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Applied Genomics, University of T\u00fcbingen, 72076 T\u00fcbingen 3 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-2096","authenticated-orcid":false,"given":"Julia M.","family":"Schulze-Hentrich","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics and Applied Genomics, University of T\u00fcbingen, 72076 T\u00fcbingen 3 , Germany"},{"name":"Institute for Bioinformatics and Medical Informatics (IBMI), University of T\u00fcbingen, 72076 T\u00fcbingen 4 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pietzsch","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen, 72076 T\u00fcbingen 1 Department of Women's Health , , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Wajngarten","sequence":"additional","affiliation":[{"name":"Research Institute for Women's Health, University of T\u00fcbingen, 72076 T\u00fcbingen 5 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali Ralhan","family":"Singh","sequence":"additional","affiliation":[{"name":"Research Institute for Women's Health, University of T\u00fcbingen, 72076 T\u00fcbingen 5 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Rall","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen, 72076 T\u00fcbingen 1 Department of Women's Health , , Germany"},{"name":"Rare Disease Center T\u00fcbingen, University of T\u00fcbingen, 72076 T\u00fcbingen 2 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-382X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Koch","sequence":"additional","affiliation":[{"name":"Research Institute for Women's Health, University of T\u00fcbingen, 72076 T\u00fcbingen 5 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2024061306492691500_DMM049379C1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.semcdb.2007.10.008","article-title":"Uterine receptivity to human embryonic implantation: histology, biomarkers, and transcriptomics","volume":"19","author":"Aghajanova","year":"2008","journal-title":"Semin. 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