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Here, we comprehensively show, for the first time, that mice lacking the \u03b12(I) chain do not have impaired bone biomechanical or structural properties, unlike oim homozygous mice. However, Mendelian inheritance was affected in male mice of both lines, and male mice null for the \u03b12(I) chain exhibited age-related loss of condition. Compound heterozygotes were generated to test whether gene dosage was responsible for the less-severe phenotype of oim heterozygotes, after allelic discrimination showed that the oim mutant allele was not downregulated in heterozygotes. Compound heterozygotes had impaired bone structural properties compared to those of oim heterozygotes, albeit to a lesser extent than those of oim homozygotes. Hence, the presence of heterotrimeric type I collagen in oim heterozygotes alleviates the effect of the oim mutant allele, but a genetic interaction between homotrimeric type I collagen and the oim mutant allele leads to bone fragility.<\/jats:p>","DOI":"10.1242\/dmm.049428","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T04:33:01Z","timestamp":1663216381000},"source":"Crossref","is-referenced-by-count":16,"title":["Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-1547","authenticated-orcid":false,"given":"Katie J.","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool 1 Department of Musculoskeletal and Ageing Science , , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Rambault","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Informatique, Universit\u00e9 de Poitiers 2 , 86073 Poitiers Cedex 9 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-9418","authenticated-orcid":false,"given":"George","family":"Bou-Gharios","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool 1 Department of Musculoskeletal and Ageing Science , , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-0032","authenticated-orcid":false,"given":"Peter D.","family":"Clegg","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool 1 Department of Musculoskeletal and Ageing Science , , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"},{"name":"The Medical Research Council Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA) 3 , Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riaz","family":"Akhtar","sequence":"additional","affiliation":[{"name":"School of Engineering, University of Liverpool 4 Department of Mechanical, Materials and Aerospace Engineering , , Liverpool L69 3GH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-2093","authenticated-orcid":false,"given":"Gabriela","family":"Czanner","sequence":"additional","affiliation":[{"name":"School of Computer Science and Mathematics, Faculty of Engineering and Technology, Liverpool John Moores University 5 , Byrom Street, Liverpool L3 3AF , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-6788","authenticated-orcid":false,"given":"Rob","family":"van \u2018t Hof","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool 1 Department of Musculoskeletal and Ageing Science , , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-1316","authenticated-orcid":false,"given":"Elizabeth G.","family":"Canty-Laird","sequence":"additional","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool 1 Department of Musculoskeletal and Ageing Science , , William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"},{"name":"The Medical Research Council Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA) 3 , Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"2022092807195898500_DMM049428C1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/S1357-2725(01)00107-8","article-title":"Phenotypic expression of osteoblast collagen in osteoarthritic bone: production of type I homotrimer","volume":"34","author":"Bailey","year":"2002","journal-title":"Int. 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