{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:04:35Z","timestamp":1772168675682,"version":"3.50.1"},"reference-count":163,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["SR\/S2\/RJN-42\/2008"],"award-info":[{"award-number":["SR\/S2\/RJN-42\/2008"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Council for Scientific and Industrial Research, Human Resource Development Group","award":["09\/733(0117)\/2009-EMR-I"],"award-info":[{"award-number":["09\/733(0117)\/2009-EMR-I"]}]},{"DOI":"10.13039\/501100005116","name":"Jawaharlal Nehru Centre for Advanced Scientific Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005116","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Circadian disturbances are early features of neurodegenerative diseases, including Huntington's disease (HD). Emerging evidence suggests that circadian decline feeds into neurodegenerative symptoms, exacerbating them. Therefore, we asked whether known neurotoxic modifiers can suppress circadian dysfunction. We performed a screen of neurotoxicity-modifier genes to suppress circadian behavioural arrhythmicity in a Drosophila circadian HD model. The molecular chaperones Hsp40 and HSP70 emerged as significant suppressors in the circadian context, with Hsp40 being the more potent mitigator. Upon Hsp40 overexpression in the Drosophila circadian ventrolateral neurons (LNv), the behavioural rescue was associated with neuronal rescue of loss of circadian proteins from small LNv soma. Specifically, there was a restoration of the molecular clock protein Period and its oscillations in young flies and a long-lasting rescue of the output neuropeptide Pigment dispersing factor. Significantly, there was a reduction in the expanded Huntingtin inclusion load, concomitant with the appearance of a spot-like Huntingtin form. Thus, we provide evidence implicating the neuroprotective chaperone Hsp40 in circadian rehabilitation. The involvement of molecular chaperones in circadian maintenance has broader therapeutic implications for neurodegenerative diseases.<\/jats:p>\n                  <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/dmm.049447","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T03:14:01Z","timestamp":1653880441000},"source":"Crossref","is-referenced-by-count":2,"title":["Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a\n                    <i>Drosophila<\/i>\n                    model of Huntington's disease"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-9625","authenticated-orcid":false,"given":"Pavitra","family":"Prakash","sequence":"first","affiliation":[{"name":"Jawaharlal Nehru Centre for Advanced Scientific Research 1 Evolutionary and Integrative Biology Unit , , Bangalore 560064 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-3404","authenticated-orcid":false,"given":"Arpit Kumar","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Centre for Advanced Scientific Research 2 Neuroscience Unit , , Bangalore 560064 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-7130","authenticated-orcid":false,"given":"Vasu","family":"Sheeba","sequence":"additional","affiliation":[{"name":"Jawaharlal Nehru Centre for Advanced Scientific Research 1 Evolutionary and Integrative Biology Unit , , Bangalore 560064 , India"},{"name":"Jawaharlal Nehru Centre for Advanced Scientific Research 2 Neuroscience Unit , , Bangalore 560064 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"2022062808391570600_DMM049447C1","doi-asserted-by":"publisher","first-page":"e1006613","DOI":"10.1371\/journal.pgen.1006613","article-title":"RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides","volume":"13","author":"Abruzzi","year":"2017","journal-title":"PLoS Genet."},{"key":"2022062808391570600_DMM049447C2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein aggregates in Huntington's disease","volume":"238","author":"Arrasate","year":"2012","journal-title":"Exp. Neurol."},{"key":"2022062808391570600_DMM049447C3","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1093\/hmg\/11.5.515","article-title":"Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy","volume":"11","author":"Bailey","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.semcdb.2003.12.010","article-title":"Roles of molecular chaperones in protein misfolding diseases","volume":"15","author":"Barral","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"2022062808391570600_DMM049447C5","doi-asserted-by":"publisher","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2022062808391570600_DMM049447C6","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1002\/cne.23728","article-title":"Experimental assessment of the network properties of the Drosophila circadian clock","volume":"523","author":"Beckwith","year":"2015","journal-title":"J. Comp. Neurol."},{"key":"2022062808391570600_DMM049447C7","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1242\/jcs.01284","article-title":"\u201cThe stress of dying\u201d: the role of heat shock proteins in the regulation of apoptosis","volume":"117","author":"Beere","year":"2004","journal-title":"J. Cell Sci."},{"key":"2022062808391570600_DMM049447C8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1159\/000495813","article-title":"Ageing population: A neurological challenge","volume":"52","author":"B\u00e9jot","year":"2019","journal-title":"Neuroepidemiology"},{"key":"2022062808391570600_DMM049447C9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.parkreldis.2017.09.013","article-title":"Circadian rhythm and autonomic dysfunction in presymptomatic and early Huntington's disease","volume":"44","author":"Bellosta Diago","year":"2017","journal-title":"Parkinsonism Relat. Disord."},{"key":"2022062808391570600_DMM049447C10","doi-asserted-by":"publisher","first-page":"14914","DOI":"10.1073\/pnas.0902882106","article-title":"Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging","volume":"106","author":"Ben-Zvi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C11","doi-asserted-by":"publisher","first-page":"6236","DOI":"10.1074\/jbc.M113.499608","article-title":"Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries","volume":"289","author":"Benbahouche","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2022062808391570600_DMM049447C12","doi-asserted-by":"publisher","first-page":"16407","DOI":"10.1073\/pnas.152330499","article-title":"Chaperoning brain degeneration","volume":"99","author":"Bonini","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fimmu.2012.00095","article-title":"The anti-inflammatory mechanisms of Hsp70","volume":"3","author":"Borges","year":"2012","journal-title":"Front Immunol"},{"key":"2022062808391570600_DMM049447C14","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1172\/JCI27607","article-title":"Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase","volume":"116","author":"Borrell-Pages","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2022062808391570600_DMM049447C15","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/hmg\/ddm315","article-title":"Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases","volume":"17","author":"Branco","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C16","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1242\/dmm.024703","article-title":"Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity","volume":"9","author":"Brehme","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"2022062808391570600_DMM049447C17","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.celrep.2014.09.042","article-title":"A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease","volume":"9","author":"Brehme","year":"2014","journal-title":"Cell Rep."},{"key":"2022062808391570600_DMM049447C18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/0748730419841468","article-title":"Neuronal activity in non-LNv clock cells is required to produce free-running rest:activity rhythms in Drosophila","volume":"34","author":"Bulthuis","year":"2019","journal-title":"J. Biol. Rhythms"},{"key":"2022062808391570600_DMM049447C19","doi-asserted-by":"publisher","first-page":"644747","DOI":"10.3389\/fmolb.2021.644747","article-title":"The molecular clock and neurodegenerative disease: a stressful time","volume":"8","author":"Carter","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"2022062808391570600_DMM049447C20","doi-asserted-by":"publisher","first-page":"10338","DOI":"10.1523\/JNEUROSCI.19-23-10338.1999","article-title":"Analysis of the role of Heat Shock Protein (Hsp) molecular chaperones in polyglutamine disease","volume":"19","author":"Chai","year":"1999","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C21","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/hmg\/9.19.2811","article-title":"Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila","volume":"9","author":"Chan","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C22","doi-asserted-by":"publisher","first-page":"19831","DOI":"10.1074\/jbc.M109613200","article-title":"Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently","volume":"277","author":"Chuang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2022062808391570600_DMM049447C23","doi-asserted-by":"publisher","first-page":"e148288","DOI":"10.1172\/JCI148288","article-title":"Defining circadian disruption in neurodegenerative disorders","volume":"131","author":"Colwell","year":"2021","journal-title":"J. Clin. Invest."},{"key":"2022062808391570600_DMM049447C24","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s12192-016-0708-2","article-title":"Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol","volume":"21","author":"Deane","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"2022062808391570600_DMM049447C25","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48308","article-title":"Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption","volume":"8","author":"Delventhal","year":"2019","journal-title":"eLife"},{"key":"2022062808391570600_DMM049447C26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-3-319-64543-8_8","article-title":"Circadian rhythms and proteostasis in aging","volume":"7","author":"Desvergne","year":"2017","journal-title":"Healthy Ageing and Longevity Circadian Rhythms and Their Impact on Aging"},{"key":"2022062808391570600_DMM049447C27","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3389\/fphar.2019.00920","article-title":"Heat-Shock proteins in neuroinflammation","volume":"10","author":"Dukay","year":"2019","journal-title":"Front. Pharmacol."},{"key":"2022062808391570600_DMM049447C28","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/nature11088","article-title":"Peroxiredoxins are conserved markers of circadian rhythms","volume":"485","author":"Edgar","year":"2012","journal-title":"Nature"},{"key":"2022062808391570600_DMM049447C29","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/ncb2838","article-title":"Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress","volume":"15","author":"Escusa-Toret","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2022062808391570600_DMM049447C30","doi-asserted-by":"publisher","first-page":"105029","DOI":"10.1016\/j.nbd.2020.105029","article-title":"Circadian alterations in patients with neurodegenerative diseases: Neuropathological basis of underlying network mechanisms","volume":"144","author":"Fifel","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"2022062808391570600_DMM049447C31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/embor.2010.203","article-title":"BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins","volume":"12","author":"Gamerdinger","year":"2011","journal-title":"EMBO Rep."},{"key":"2022062808391570600_DMM049447C32","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.molcel.2015.07.012","article-title":"Human Hsp70 disaggregase reverses Parkinson's-linked \u03b1-Synuclein amyloid fibrils","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"2022062808391570600_DMM049447C33","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1083\/jcb.146.6.1239","article-title":"Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera","volume":"146","author":"Garc\u00eda-Mata","year":"1999","journal-title":"J. Cell Biol."},{"key":"2022062808391570600_DMM049447C34","doi-asserted-by":"publisher","first-page":"e4595","DOI":"10.1371\/journal.pone.0004595","article-title":"Hsp40 couples with the CSPalpha chaperone complex upon induction of the heat shock response","volume":"4","author":"Gibbs","year":"2009","journal-title":"PLoS ONE"},{"key":"2022062808391570600_DMM049447C35","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2022062808391570600_DMM049447C36","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11910-010-0163-x","article-title":"Asymptomatic sleep abnormalities are a common early feature in patients with Huntington's disease","volume":"11","author":"Goodman","year":"2011","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"2022062808391570600_DMM049447C37","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3389\/fnins.2017.00248","article-title":"The role of co-chaperones in synaptic proteostasis and neurodegenerative disease","volume":"11","author":"Gorenberg","year":"2017","journal-title":"Front. Neurosci."},{"key":"2022062808391570600_DMM049447C38","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/nature02935","article-title":"Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain","volume":"431","author":"Grima","year":"2004","journal-title":"Nature"},{"key":"2022062808391570600_DMM049447C39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","article-title":"Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila","volume":"40","author":"Gunawardena","year":"2003","journal-title":"Neuron"},{"key":"2022062808391570600_DMM049447C40","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.tibs.2006.06.009","article-title":"Huntington's disease: seeing the pathogenic process through a genetic lens","volume":"31","author":"Gusella","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"2022062808391570600_DMM049447C41","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1093\/hmg\/ddr314","article-title":"Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of Huntington disease","volume":"20","author":"Guzhova","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C42","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molcel.2010.01.001","article-title":"A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation","volume":"37","author":"Hageman","year":"2010","journal-title":"Mol. Cell"},{"key":"2022062808391570600_DMM049447C43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0006-8993(02)04275-0","article-title":"Overexpression of heat shock protein 70 in R6\/2 Huntington's disease mice has only modest effects on disease progression","volume":"970","author":"Hansson","year":"2003","journal-title":"Brain Res."},{"key":"2022062808391570600_DMM049447C44","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nsmb.1591","article-title":"Converging concepts of protein folding in vitro and in vivo","volume":"16","author":"Hartl","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2022062808391570600_DMM049447C45","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1093\/hmg\/ddh144","article-title":"Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach","volume":"13","author":"Hay","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C46","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1073\/pnas.92.2.612","article-title":"The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster","volume":"92","author":"Helfrich-F\u00f6rster","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C47","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/(SICI)1096-9861(19970414)380:3&lt;335::AID-CNE4&gt;3.0.CO;2-3","article-title":"Development of pigment-dispersing hormone-immunoreactive neurons in the nervous system of Drosophila melanogaster","volume":"380","author":"Helfrich-Forster","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"2022062808391570600_DMM049447C48","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in ageing","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022062808391570600_DMM049447C49","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fnagi.2017.00170","article-title":"Neurodegeneration and the circadian clock","volume":"9","author":"Hood","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"2022062808391570600_DMM049447C50","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1471-2202-9-119","article-title":"CLOCK expression identifies developing circadian oscillator neurons in the brains of Drosophila embryos","volume":"9","author":"Houl","year":"2008","journal-title":"BMC Neurosci."},{"key":"2022062808391570600_DMM049447C163","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1177\/0748730409333171","article-title":"HSP90, a capacitor of behavioral variation","volume":"24","author":"Hung","year":"2009","journal-title":"J. Biol. Rhythms"},{"key":"2022062808391570600_DMM049447C51","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1002\/ijc.2910600520","article-title":"Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells","volume":"60","author":"J\u00e4\u00e4ttel\u00e4","year":"1995","journal-title":"Int. J. Cancer"},{"key":"2022062808391570600_DMM049447C52","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1093\/hmg\/9.13.2009","article-title":"Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity","volume":"9","author":"Jana","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C53","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.neulet.2012.03.074","article-title":"GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins","volume":"516","author":"Jiang","year":"2012","journal-title":"Neurosci. Lett."},{"key":"2022062808391570600_DMM049447C54","doi-asserted-by":"publisher","first-page":"4464","DOI":"10.1111\/febs.15617","article-title":"Alternative systems for misfolded protein clearance: life beyond the proteasome","volume":"288","author":"Johnston","year":"2021","journal-title":"FEBS J."},{"key":"2022062808391570600_DMM049447C55","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","article-title":"Aggresomes: a cellular response to misfolded proteins","volume":"143","author":"Johnston","year":"1998","journal-title":"J. Cell Biol."},{"key":"2022062808391570600_DMM049447C56","doi-asserted-by":"publisher","first-page":"47870","DOI":"10.1074\/jbc.M203159200","article-title":"Parkin accumulation in aggresomes due to proteasome impairment","volume":"277","author":"Junn","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2022062808391570600_DMM049447C57","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/s41556-021-00800-z","article-title":"Reciprocal regulation of chaperone-mediated autophagy and the circadian clock","volume":"23","author":"Juste","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"2022062808391570600_DMM049447C58","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.molcel.2016.03.017","article-title":"The S\/T-rich motif in the DNAJB6 chaperone delays polyglutamine aggregation and the onset of disease in a mouse model","volume":"62","author":"Kakkar","year":"2016","journal-title":"Mol. Cell"},{"key":"2022062808391570600_DMM049447C59","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.addr.2009.02.003","article-title":"Induction of heat shock proteins for protection against oxidative stress","volume":"61","author":"Kalmar","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"2022062808391570600_DMM049447C60","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrm2941","article-title":"The HSP70 chaperone machinery: J proteins as drivers of functional specificity","volume":"11","author":"Kampinga","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022062808391570600_DMM049447C61","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/S1474-4422(16)00099-5","article-title":"Heat shock proteins as potential targets for protective strategies in neurodegeneration","volume":"15","author":"Kampinga","year":"2016","journal-title":"Lancet Neurol."},{"key":"2022062808391570600_DMM049447C62","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12192-018-0948-4","article-title":"Function, evolution, and structure of J-domain proteins","volume":"24","author":"Kampinga","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"2022062808391570600_DMM049447C63","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nm0202-143","article-title":"Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine","volume":"8","author":"Karpuj","year":"2002","journal-title":"Nat. Med."},{"key":"2022062808391570600_DMM049447C64","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/iub.1274","article-title":"Regulation of apoptosis by heat shock proteins","volume":"66","author":"Kennedy","year":"2014","journal-title":"IUBMB Life"},{"key":"2022062808391570600_DMM049447C65","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/ncb863","article-title":"Polyglutamine protein aggregates are dynamic","volume":"4","author":"Kim","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"2022062808391570600_DMM049447C66","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-biochem-060208-092442","article-title":"Molecular chaperone functions in protein folding and proteostasis","volume":"82","author":"Kim","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"2022062808391570600_DMM049447C67","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.bbrc.2017.12.021","article-title":"Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease","volume":"495","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2022062808391570600_DMM049447C68","doi-asserted-by":"publisher","first-page":"8772","DOI":"10.1074\/jbc.275.12.8772","article-title":"Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract","volume":"275","author":"Kobayashi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2022062808391570600_DMM049447C69","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","article-title":"Aggresomes, inclusion bodies and protein aggregation","volume":"10","author":"Kopito","year":"2000","journal-title":"Trends Cell Biol."},{"key":"2022062808391570600_DMM049447C70","doi-asserted-by":"publisher","first-page":"100285","DOI":"10.1016\/j.xpro.2020.100285","article-title":"Open-source computational framework for studying Drosophila behavioral phase","volume":"2","author":"Kostadinov","year":"2021","journal-title":"STAR Protoc."},{"key":"2022062808391570600_DMM049447C71","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.nbd.2011.12.034","article-title":"Loss of circadian clock accelerates aging in neurodegeneration-prone mutants","volume":"45","author":"Krishnan","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"2022062808391570600_DMM049447C72","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.expneurol.2010.12.011","article-title":"Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease","volume":"228","author":"Kudo","year":"2011","journal-title":"Exp. Neurol."},{"key":"2022062808391570600_DMM049447C73","doi-asserted-by":"publisher","first-page":"13497","DOI":"10.1073\/pnas.1002081107","article-title":"Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila","volume":"107","author":"Kula-Eversole","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C74","doi-asserted-by":"publisher","first-page":"e833","DOI":"10.1038\/cddis.2013.351","article-title":"Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110","volume":"4","author":"Kuo","year":"2013","journal-title":"Cell Death Dis."},{"key":"2022062808391570600_DMM049447C75","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/brain\/aws022","article-title":"Suppression of protein aggregation by chaperone modification of high molecular weight complexes","volume":"135","author":"Labbadia","year":"2012","journal-title":"Brain"},{"key":"2022062808391570600_DMM049447C76","doi-asserted-by":"publisher","first-page":"6_92","DOI":"10.5363\/tits.22.6_92","article-title":"The challenge of neurodegenerative diseases in an aging population","volume":"22","author":"Lassonde","year":"2017","journal-title":"Trends Sci."},{"key":"2022062808391570600_DMM049447C77","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/mp.2016.47","article-title":"Circadian rhythm dysfunction: a novel environmental risk factor for Parkinson's disease","volume":"22","author":"Lauretti","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"2022062808391570600_DMM049447C78","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/ana.24495","article-title":"Sleep deficits but no metabolic deficits in premanifest Huntington's disease","volume":"78","author":"Lazar","year":"2015","journal-title":"Ann. Neurol."},{"key":"2022062808391570600_DMM049447C79","doi-asserted-by":"publisher","first-page":"e0126972","DOI":"10.1371\/journal.pone.0126972","article-title":"Sleep physiology alterations precede plethoric phenotypic changes in R6\/1 Huntington's disease mice","volume":"10","author":"Lebreton","year":"2015","journal-title":"PLoS ONE"},{"key":"2022062808391570600_DMM049447C80","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1073\/pnas.0400243101","article-title":"Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease","volume":"101","author":"Lee","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C81","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S1474-4422(18)30461-7","article-title":"Association between circadian rhythms and neurodegenerative diseases","volume":"18","author":"Leng","year":"2019","journal-title":"Lancet Neurol."},{"key":"2022062808391570600_DMM049447C82","first-page":"D397","article-title":"CGDB: a database of circadian genes in eukaryotes","volume":"45","author":"Li","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2022062808391570600_DMM049447C83","doi-asserted-by":"publisher","first-page":"38183","DOI":"10.1074\/jbc.M110.160218","article-title":"Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle","volume":"285","author":"Lotz","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2022062808391570600_DMM049447C84","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63056","article-title":"A transcriptomic taxonomy of Drosophila circadian neurons around the clock","volume":"10","author":"Ma","year":"2021","journal-title":"eLife"},{"key":"2022062808391570600_DMM049447C85","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1093\/hmg\/ddt667","article-title":"Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease","volume":"23","author":"Maheshwari","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C86","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fnmol.2017.00098","article-title":"Chaperones as suppressors of protein misfolded oligomer toxicity","volume":"10","author":"Mannini","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"2022062808391570600_DMM049447C87","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12192-013-0448-5","article-title":"DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios","volume":"19","author":"M\u00e5nsson","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"2022062808391570600_DMM049447C88","doi-asserted-by":"publisher","first-page":"10199","DOI":"10.1523\/JNEUROSCI.1694-10.2010","article-title":"Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding","volume":"30","author":"Maywood","year":"2010","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C89","volume-title":"Handbook of Biological Statistics","author":"McDonald","year":"2014"},{"key":"2022062808391570600_DMM049447C90","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1096\/fj.07-099689","article-title":"Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease","volume":"22","author":"McLear","year":"2008","journal-title":"FASEB J."},{"key":"2022062808391570600_DMM049447C91","doi-asserted-by":"publisher","first-page":"e1005171","DOI":"10.1371\/journal.pgen.1005171","article-title":"Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy","volume":"11","author":"Means","year":"2015","journal-title":"PLoS Genet."},{"key":"2022062808391570600_DMM049447C92","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.tibs.2009.06.006","article-title":"Post-translational modifications in circadian rhythms","volume":"34","author":"Mehra","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"2022062808391570600_DMM049447C93","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"2022062808391570600_DMM049447C94","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/cells7050037","article-title":"Autophagy in age-associated neurodegeneration","volume":"7","author":"Metaxakis","year":"2018","journal-title":"Cells"},{"key":"2022062808391570600_DMM049447C95","doi-asserted-by":"publisher","first-page":"778","DOI":"10.15252\/embj.201489524","article-title":"Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition","volume":"34","author":"Miller","year":"2015","journal-title":"EMBO J."},{"key":"2022062808391570600_DMM049447C96","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","article-title":"Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease","volume":"25","author":"Morton","year":"2005","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C97","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1093\/hmg\/ddu047","article-title":"Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment","volume":"23","author":"Morton","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C98","doi-asserted-by":"publisher","first-page":"7841","DOI":"10.1073\/pnas.140202897","article-title":"Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils","volume":"97","author":"Muchowski","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C99","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1093\/hmg\/ddn255","article-title":"Protective role of Engrailed in a Drosophila model of Huntington's disease","volume":"17","author":"Mugat","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C100","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1755-8794-6-52","article-title":"NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases","volume":"6","author":"Na","year":"2013","journal-title":"BMC Med. Genomics"},{"key":"2022062808391570600_DMM049447C101","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.tibs.2018.02.003","article-title":"Protein disaggregation in multicellular organisms","volume":"43","author":"Nillegoda","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"2022062808391570600_DMM049447C102","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1523\/JNEUROSCI.3915-05.2006","article-title":"Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods","volume":"26","author":"Nitabach","year":"2006","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C103","doi-asserted-by":"publisher","first-page":"12038","DOI":"10.1073\/pnas.201112398","article-title":"Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection","volume":"98","author":"Nollen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C104","first-page":"7139","article-title":"Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion","volume":"62","author":"Nylandsted","year":"2002","journal-title":"Cancer Res."},{"key":"2022062808391570600_DMM049447C105","doi-asserted-by":"publisher","first-page":"37192","DOI":"10.1074\/jbc.M113.486944","article-title":"A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70","volume":"288","author":"Ormsby","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2022062808391570600_DMM049447C106","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.nbscr.2016.11.004","article-title":"Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington's disease","volume":"2","author":"Ouk","year":"2017","journal-title":"Neurobiol. Sleep Circadian Rhythms"},{"key":"2022062808391570600_DMM049447C107","doi-asserted-by":"publisher","first-page":"7869","DOI":"10.1523\/JNEUROSCI.0649-07.2007","article-title":"Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease","volume":"27","author":"Pallier","year":"2007","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C108","doi-asserted-by":"publisher","first-page":"3608","DOI":"10.1073\/pnas.97.7.3608","article-title":"Differential regulation of circadian pacemaker output by separate clock genes in Drosophila","volume":"97","author":"Park","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C109","doi-asserted-by":"publisher","first-page":"pdb prot5519","DOI":"10.1101\/pdb.prot5519","article-title":"Processing circadian data collected from the Drosophila Activity Monitoring (DAM) System","volume":"2010","author":"Pfeiffenberger","year":"2010","journal-title":"Cold Spring Harb. Protoc."},{"key":"2022062808391570600_DMM049447C110","doi-asserted-by":"publisher","first-page":"7479","DOI":"10.1096\/fj.201802366RR","article-title":"Preservation of circadian rhythms by the protein folding chaperone, BiP","volume":"33","author":"Pickard","year":"2019","journal-title":"FASEB J."},{"key":"2022062808391570600_DMM049447C111","doi-asserted-by":"publisher","first-page":"e51069","DOI":"10.1371\/journal.pone.0051069","article-title":"Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism","volume":"7","author":"Popiel","year":"2012","journal-title":"PLoS ONE"},{"key":"2022062808391570600_DMM049447C112","doi-asserted-by":"publisher","first-page":"e0175073","DOI":"10.1371\/journal.pone.0175073","article-title":"Oscillating PDF in termini of circadian pacemaker neurons and synchronous molecular clocks in downstream neurons are not sufficient for sustenance of activity rhythms in constant darkness","volume":"12","author":"Prakash","year":"2017","journal-title":"PLoS ONE"},{"key":"2022062808391570600_DMM049447C113","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0092-8674(00)81676-1","article-title":"A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila","volume":"99","author":"Renn","year":"1999","journal-title":"Cell"},{"key":"2022062808391570600_DMM049447C114","doi-asserted-by":"publisher","first-page":"e8376","DOI":"10.15252\/msb.20188376","article-title":"Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes","volume":"14","author":"Rey","year":"2018","journal-title":"Mol. Syst. Biol."},{"key":"2022062808391570600_DMM049447C115","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1111\/j.1460-9568.2007.05317.x","article-title":"Neuronal death in Drosophila triggered by GAL4 accumulation","volume":"25","author":"Rezaval","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"2022062808391570600_DMM049447C116","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1016\/j.yexcr.2007.07.034","article-title":"Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine","volume":"313","author":"Rujano","year":"2007","journal-title":"Exp. Cell Res."},{"key":"2022062808391570600_DMM049447C117","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1016\/j.celrep.2019.01.072","article-title":"Diurnal rhythms spatially and temporally organize autophagy","volume":"26","author":"Ryzhikov","year":"2019","journal-title":"Cell Rep."},{"key":"2022062808391570600_DMM049447C118","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/hmg\/ddi032","article-title":"Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis","volume":"14","author":"Sang","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C119","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48301","article-title":"Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity","volume":"8","author":"Schlichting","year":"2019","journal-title":"eLife"},{"key":"2022062808391570600_DMM049447C120","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"2022062808391570600_DMM049447C121","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1177\/0748730414523559","article-title":"HSP90 affects the stability of BMAL1 and circadian gene expression","volume":"29","author":"Schneider","year":"2014","journal-title":"J. Biol. Rhythms"},{"key":"2022062808391570600_DMM049447C122","doi-asserted-by":"publisher","first-page":"282","DOI":"10.15252\/embj.201797212","article-title":"Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex","volume":"37","author":"Scior","year":"2018","journal-title":"EMBO J."},{"key":"2022062808391570600_DMM049447C123","doi-asserted-by":"publisher","first-page":"e8298","DOI":"10.1371\/journal.pone.0008298","article-title":"RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide's circadian functions","volume":"4","author":"Shafer","year":"2009","journal-title":"PLoS One"},{"key":"2022062808391570600_DMM049447C124","doi-asserted-by":"publisher","first-page":"5946","DOI":"10.1523\/JNEUROSCI.22-14-05946.2002","article-title":"Sequential nuclear accumulation of the clock proteins Period and Timeless in the pacemaker neurons of Drosophila melanogaster","volume":"22","author":"Shafer","year":"2002","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C125","doi-asserted-by":"publisher","first-page":"172892","DOI":"10.1016\/j.pbb.2020.172892","article-title":"Long-term exposure to constant light induces dementia, oxidative stress and promotes aggregation of sub-pathological Abeta42 in Wistar rats","volume":"192","author":"Sharma","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"2022062808391570600_DMM049447C126","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.cub.2008.08.033","article-title":"Large ventral lateral neurons modulate arousal and sleep in Drosophila","volume":"18","author":"Sheeba","year":"2008","journal-title":"Curr. Biol."},{"key":"2022062808391570600_DMM049447C127","doi-asserted-by":"publisher","first-page":"e11628","DOI":"10.1371\/journal.pone.0011628","article-title":"Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila","volume":"5","author":"Sheeba","year":"2010","journal-title":"PLoS ONE"},{"key":"2022062808391570600_DMM049447C128","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/genetics\/165.3.1233","article-title":"Genetic modifiers of tauopathy in Drosophila","volume":"165","author":"Shulman","year":"2003","journal-title":"Genetics"},{"key":"2022062808391570600_DMM049447C129","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1093\/hmg\/10.12.1307","article-title":"Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease","volume":"10","author":"Sittler","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C130","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/jnr.24505","article-title":"Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis","volume":"97","author":"Smarr","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"2022062808391570600_DMM049447C131","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.nbd.2010.07.013","article-title":"Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis","volume":"40","author":"Soneson","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"2022062808391570600_DMM049447C132","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ceb.2013.12.006","article-title":"Sorting out the trash: the spatial nature of eukaryotic protein quality control","volume":"26","author":"Sontag","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"2022062808391570600_DMM049447C133","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1083\/jcb.201106037","article-title":"Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae","volume":"195","author":"Specht","year":"2011","journal-title":"J. Cell Biol."},{"key":"2022062808391570600_DMM049447C134","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/35099568","article-title":"Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"2022062808391570600_DMM049447C135","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fnmol.2014.00069","article-title":"A central role for ubiquitination within a circadian clock protein modification code","volume":"7","author":"Stojkovic","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"2022062808391570600_DMM049447C136","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nature02926","article-title":"Coupled oscillators control morning and evening locomotor behaviour of Drosophila","volume":"431","author":"Stoleru","year":"2004","journal-title":"Nature"},{"key":"2022062808391570600_DMM049447C137","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/hmg\/dds441","article-title":"Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease","volume":"22","author":"Sutton","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C138","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1523\/JNEUROSCI.4522-06.2007","article-title":"The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes","volume":"27","author":"Tagawa","year":"2007","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C139","doi-asserted-by":"publisher","first-page":"e24521","DOI":"10.1371\/journal.pone.0024521","article-title":"Synchronization of circadian Per2 rhythms and HSF1-BMAL1:CLOCK interaction in mouse fibroblasts after short-term heat shock pulse","volume":"6","author":"Tamaru","year":"2011","journal-title":"PLoS ONE"},{"key":"2022062808391570600_DMM049447C140","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/bs.mie.2016.09.084","article-title":"Kinetics of protein aggregates disposal by aggrephagy","volume":"588","author":"Tan","year":"2017","journal-title":"Methods Enzymol."},{"key":"2022062808391570600_DMM049447C141","doi-asserted-by":"publisher","first-page":"a004440","DOI":"10.1101\/cshperspect.a004440","article-title":"Aging as an event of proteostasis collapse","volume":"3","author":"Taylor","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"2022062808391570600_DMM049447C142","doi-asserted-by":"publisher","first-page":"581374","DOI":"10.3389\/fnagi.2020.581374","article-title":"Molecular chaperones: a double-edged sword in neurodegenerative diseases","volume":"12","author":"Tittelmeier","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"2022062808391570600_DMM049447C143","doi-asserted-by":"publisher","first-page":"e103954","DOI":"10.15252\/embj.2019103954","article-title":"The HSP110\/HSP70 disaggregation system generates spreading-competent toxic alpha-synuclein species","volume":"39","author":"Tittelmeier","year":"2020","journal-title":"EMBO J."},{"key":"2022062808391570600_DMM049447C144","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.cmet.2018.05.023","article-title":"Autophagy regulates the liver clock and glucose metabolism by degrading CRY1","volume":"28","author":"Toledo","year":"2018","journal-title":"Cell Metab."},{"key":"2022062808391570600_DMM049447C145","doi-asserted-by":"publisher","first-page":"117","DOI":"10.5665\/sleep.2314","article-title":"Suprachiasmatic Nucleus neuropeptide expression in patients with Huntington's Disease","volume":"36","author":"van Wamelen","year":"2013","journal-title":"Sleep"},{"key":"2022062808391570600_DMM049447C146","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.cub.2003.09.030","article-title":"A self-sustaining, light-entrainable circadian oscillator in the Drosophila brain","volume":"13","author":"Veleri","year":"2003","journal-title":"Curr. Biol."},{"key":"2022062808391570600_DMM049447C147","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1007\/s00415-020-10334-3","article-title":"The sleep and circadian problems of Huntington's disease: when, why and their importance","volume":"268","author":"Voysey","year":"2021","journal-title":"J. Neurol."},{"key":"2022062808391570600_DMM049447C148","doi-asserted-by":"publisher","first-page":"9104","DOI":"10.1523\/JNEUROSCI.2250-09.2009","article-title":"Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease","volume":"29","author":"Wacker","year":"2009","journal-title":"J. Neurosci."},{"key":"2022062808391570600_DMM049447C149","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.nbscr.2016.12.002","article-title":"Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease","volume":"2","author":"Wang","year":"2017","journal-title":"Neurobiol. Sleep Circadian Rhythms"},{"key":"2022062808391570600_DMM049447C150","doi-asserted-by":"publisher","first-page":"616434","DOI":"10.3389\/fcell.2020.616434","article-title":"Rheostatic balance of circadian rhythm and autophagy in metabolism and disease","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2022062808391570600_DMM049447C151","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.cub.2005.04.058","article-title":"HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome","volume":"15","author":"Westhoff","year":"2005","journal-title":"Curr. Biol."},{"key":"2022062808391570600_DMM049447C152","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1177\/0748730418790401","article-title":"Circadian-based treatment strategy effective in the BACHD mouse model of Huntington's disease","volume":"33","author":"Whittaker","year":"2018","journal-title":"J. Biol. Rhythms"},{"key":"2022062808391570600_DMM049447C153","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1093\/hmg\/11.9.1137","article-title":"Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin","volume":"11","author":"Wyttenbach","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2022062808391570600_DMM049447C154","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-0-387-39954-6_7","article-title":"The role of heat shock proteins during neurodegeneration in Alzheimer's, Parkinson's and Huntington's disease","volume-title":"Heat Shock Proteins in Neural Cells","author":"Wyttenbach","year":"2009"},{"key":"2022062808391570600_DMM049447C155","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1073\/pnas.97.6.2898","article-title":"Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease","volume":"97","author":"Wyttenbach","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022062808391570600_DMM049447C156","doi-asserted-by":"publisher","first-page":"e1008356","DOI":"10.1371\/journal.pgen.1008356","article-title":"Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons","volume":"15","author":"Xu","year":"2019","journal-title":"PLoS Genet."},{"key":"2022062808391570600_DMM049447C157","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.celrep.2019.03.015","article-title":"Circadian clocks function in concert with heat shock organizing protein to modulate mutant Huntingtin aggregation and toxicity","volume":"27","author":"Xu","year":"2019","journal-title":"Cell Rep."},{"key":"2022062808391570600_DMM049447C158","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1016\/j.celrep.2016.11.053","article-title":"The Drosophila clock neuron network features diverse coupling modes and requires network-wide coherence for robust circadian rhythms","volume":"17","author":"Yao","year":"2016","journal-title":"Cell Rep."},{"key":"2022062808391570600_DMM049447C159","volume-title":"Biostatistical Analysis","author":"Zar","year":"2010"},{"key":"2022062808391570600_DMM049447C160","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1091\/mbc.e11-05-0388","article-title":"Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes","volume":"22","author":"Zhang","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"2022062808391570600_DMM049447C161","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1242\/dmm.000653","article-title":"Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model","volume":"2","author":"Zhang","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"2022062808391570600_DMM049447C162","doi-asserted-by":"publisher","first-page":"48417","DOI":"10.1074\/jbc.M104140200","article-title":"Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation","volume":"276","author":"Zhou","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049447\/2146380\/dmm049447.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049447\/2150076\/dmm049447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049447\/2150076\/dmm049447.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T04:39:40Z","timestamp":1656391180000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/15\/6\/dmm049447\/275822\/Hsp40-overexpression-in-pacemaker-neurons-delays"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":163,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.049447","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.27.474320","asserted-by":"object"}]},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"article-number":"dmm049447"}}