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With global increases in ageing populations and obesity, multimorbidity is a rapidly growing clinical issue in the context of cancer. Cancer is also genetically heterogeneous, with a tumour's unique profile determining its incidence of metastasis, degree of cachexia and response to therapeutics. These complexities of human cancer are difficult to replicate in animal models and are, in part, responsible for the failures in translational cancer research. In this Perspective, we highlight the fruit fly, Drosophila melanogaster, as a powerful model organism to investigate multimorbidity and tumour diversity. We also highlight how harnessing these complexities in Drosophila can, potentially, enhance cancer research and advance therapeutic discoveries.<\/jats:p>","DOI":"10.1242\/dmm.049513","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T12:54:37Z","timestamp":1648472077000},"source":"Crossref","is-referenced-by-count":9,"title":["Embracing complexity in <i>Drosophila<\/i> cancer models"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-5932","authenticated-orcid":false,"given":"Courtney","family":"Choutka","sequence":"first","affiliation":[{"name":"Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, United Kingdom"},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, United Kingdom"},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-4241","authenticated-orcid":false,"given":"Susumu","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, United Kingdom"},{"name":"Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"2022032812542544100_DMM049513C1","doi-asserted-by":"publisher","first-page":"3798","DOI":"10.3390\/cancers12123798","article-title":"Obesity and cancer metastasis: molecular and translational perspectives","volume":"12","author":"Annett","year":"2020","journal-title":"Cancers"},{"key":"2022032812542544100_DMM049513C2","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1016\/j.afos.2021.03.002","article-title":"Sarcopenia and mortality in cancer: a meta-analysis","volume":"7","author":"Au","year":"2021","journal-title":"Osteoporos. 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