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Understanding the mechanisms of cellular damage induced by radiation treatment is important in order to design methods of radioprotection. In addition, it is crucial to recognize the indirect effects of irradiation and the systemic responses that may alter saliva secretion. In this study, radiation was delivered to murine submandibular glands (SMGs) bilaterally, using a 137Cs gamma ray irradiator, or unilaterally, using a small-animal radiation research platform (SARRP). Analysis at 3, 24 and 48\u2005h showed dynamic changes in mRNA and protein expression in SMGs irradiated bilaterally. Unilateral irradiation using the SARRP caused similar changes in the irradiated SMGs, as well as significant off-target, bystander effects in the non-irradiated contralateral SMGs.<\/jats:p>","DOI":"10.1242\/dmm.049570","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T03:41:45Z","timestamp":1666237305000},"source":"Crossref","is-referenced-by-count":10,"title":["Short-term and bystander effects of radiation on murine submandibular glands"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8952-2061","authenticated-orcid":false,"given":"Hitoshi","family":"Uchida","sequence":"first","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center 1 , Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-9785","authenticated-orcid":false,"given":"Matthew H.","family":"Ingalls","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center 1 , Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-2754","authenticated-orcid":false,"given":"Eri O.","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center 1 , Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-6988","authenticated-orcid":false,"given":"Carl J.","family":"Johnston","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 2 Department of Pediatrics , , Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-5282","authenticated-orcid":false,"given":"Eric","family":"Hernady","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 3 Department of Radiation Oncology , , Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-4971","authenticated-orcid":false,"given":"Roberta C.","family":"Faustoferri","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, University of Rochester Medical Center 1 , Rochester, NY 14642 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8045-3119","authenticated-orcid":false,"given":"Catherine E.","family":"Ovitt","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 4 Department of Biomedical Genetics , , Rochester, NY 14642 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"2022111010084441800_DMM049570C1","doi-asserted-by":"publisher","first-page":"L30","DOI":"10.1152\/ajplung.2001.280.1.L30","article-title":"Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells","volume":"280","author":"Araya","year":"2001","journal-title":"Am. 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