{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:20:57Z","timestamp":1790659257283,"version":"4.1.0"},"reference-count":62,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["18K19537"],"award-info":[{"award-number":["18K19537"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21K19478"],"award-info":[{"award-number":["21K19478"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012833","name":"Niigata University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012833","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016289","name":"Taiju Life Social Welfare Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016289","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Serotonin (5-HT) is one of the key bioamines of nonalcoholic fatty liver disease (NAFLD). Its mechanism of action in autonomic neural signal pathways remains unexplained; hence, we evaluated the involvement of 5-HT and related signaling pathways via autonomic nerves in NAFLD. Diet-induced NAFLD animal models were developed using wild-type and melanocortin 4 receptor (MC4R) knockout (MC4RKO) mice, and the effects of the autonomic neural axis on NAFLD physiology, 5-HT and its receptors (HTRs), and lipid metabolism-related genes were assessed by applying hepatic nerve blockade. Hepatic neural blockade retarded the progression of NAFLD by reducing 5-HT in the small intestine, hepatic HTR2A and hepatic lipogenic gene expression, and treatment with an HTR2A antagonist reproduced these effects. The effects were milder in MC4RKO mice, and brain 5-HT and HTR2C expression did not correlate with peripheral neural blockade. Our study demonstrates that the autonomic liver-gut neural axis is involved in the etiology of diet-induced NAFLD and that 5-HT and HTR2A are key factors, implying that the modulation of the axis and use of HTR2A antagonists are potentially novel therapeutic strategies for NAFLD treatment.<\/jats:p>\n               <jats:p>This article has an associated First Person interview with the first author of the paper.<\/jats:p>","DOI":"10.1242\/dmm.049612","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T07:19:31Z","timestamp":1656487171000},"source":"Crossref","is-referenced-by-count":19,"title":["Involvement of the liver-gut peripheral neural axis in nonalcoholic fatty liver disease pathologies via hepatic HTR2A"],"prefix":"10.1242","volume":"15","author":[{"given":"Takashi","family":"Owaki","sequence":"first","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-4400","authenticated-orcid":false,"given":"Kenya","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"},{"name":"Niigata University School of Medicine 2 Department of General Medicine , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Ko","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuo","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nagoya","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Shibata","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyumi","family":"Oda","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeki","family":"Sato","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Setsu","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sakamaki","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroteru","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[{"name":"Graduate School of Medical and Dental Sciences, Niigata University 1 Division of Gastroenterology and Hepatology , , Niigata 951-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"2022072608130015000_DMM049612C1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fmed.2020.00062","article-title":"Hepatic autonomic nervous system and neurotrophic factors regulate the pathogenesis and progression of non-alcoholic fatty liver disease","volume":"7","author":"Amir","year":"2020","journal-title":"Front. Med."},{"key":"2022072608130015000_DMM049612C2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1152\/physiolgenomics.00123.2003","article-title":"Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice","volume":"16","author":"Arens","year":"2003","journal-title":"Physiol. Genomics"},{"key":"2022072608130015000_DMM049612C3","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/JOE-18-0596","article-title":"The melanocortin pathway and control of appetite-progress and therapeutic implications","volume":"241","author":"Baldini","year":"2019","journal-title":"J. Endocrinol."},{"key":"2022072608130015000_DMM049612C4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"2022072608130015000_DMM049612C5","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1016\/S0140-6736(18)32328-6","article-title":"Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial","volume":"392","author":"Bohula","year":"2018","journal-title":"Lancet"},{"key":"2022072608130015000_DMM049612C6","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1056\/NEJMoa1808721","article-title":"Cardiovascular safety of lorcaserin in overweight or obese patients","volume":"379","author":"Bohula","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2022072608130015000_DMM049612C7","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/194927b0","article-title":"Aggregation of blood platelets by adenosine diphosphate and its reversal","volume":"194","author":"Born","year":"1962","journal-title":"Nature"},{"key":"2022072608130015000_DMM049612C8","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"2022072608130015000_DMM049612C9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"2022072608130015000_DMM049612C10","doi-asserted-by":"publisher","first-page":"4824","DOI":"10.1038\/s41467-018-07287-7","article-title":"Serotonin signals through a gut-liver axis to regulate hepatic steatosis","volume":"9","author":"Choi","year":"2018","journal-title":"Nat. Commun."},{"key":"2022072608130015000_DMM049612C11","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/JOE-19-0546","article-title":"Serotonergic regulation of energy metabolism in peripheral tissues","volume":"245","author":"Choi","year":"2020","journal-title":"J. Endocrinol."},{"key":"2022072608130015000_DMM049612C12","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/nm.3766","article-title":"Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis","volume":"21","author":"Crane","year":"2015","journal-title":"Nat. Med."},{"key":"2022072608130015000_DMM049612C13","doi-asserted-by":"publisher","first-page":"119951","DOI":"10.1016\/j.lfs.2021.119951","article-title":"Overfeeding during development induces temporally-dependent changes in areas controlling food intake in the brains of male Wistar rats","volume":"285","author":"de Andrade Silva","year":"2021","journal-title":"Life Sci."},{"key":"2022072608130015000_DMM049612C14","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1517\/13543784.13.7.865","article-title":"Sarpogrelate: cardiovascular and renal clinical potential","volume":"13","author":"Doggrell","year":"2004","journal-title":"Expert Opin. Investig. Drugs"},{"key":"2022072608130015000_DMM049612C15","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1038\/nm.2490","article-title":"Stimulating healthy tissue regeneration by targeting the 5-HTB receptor in chronic liver disease","volume":"17","author":"Ebrahimkhani","year":"2011","journal-title":"Nat. Med."},{"key":"2022072608130015000_DMM049612C16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"2022072608130015000_DMM049612C17","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1124\/jpet.111.181834","article-title":"Serotonin receptor type 3 antagonists improve obesity-associated fatty liver disease in mice","volume":"339","author":"Haub","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2022072608130015000_DMM049612C18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1126\/science.aaq0365","article-title":"Nerves switch on angiogenic metabolism","volume":"358","author":"Hayakawa","year":"2017","journal-title":"Science"},{"key":"2022072608130015000_DMM049612C19","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.jhep.2019.01.035","article-title":"The degree of hepatic steatosis associates with impaired cardiac and autonomic function","volume":"70","author":"Houghton","year":"2019","journal-title":"J. Hepatol."},{"key":"2022072608130015000_DMM049612C20","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1113\/JP277994","article-title":"Liver sympathetic denervation reverses obesity-induced hepatic steatosis","volume":"597","author":"Hurr","year":"2019","journal-title":"J. Physiol."},{"key":"2022072608130015000_DMM049612C21","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1507\/endocrj.EJ18-0241","article-title":"Regulation of compensatory \u03b2-cell proliferation by inter-organ networks from the liver to pancreatic \u03b2-cells","volume":"65","author":"Imai","year":"2018","journal-title":"Endocr. J."},{"key":"2022072608130015000_DMM049612C22","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1126\/science.1163971","article-title":"Regulation of pancreatic \u03b2 cell mass by neuronal signals from the liver","volume":"322","author":"Imai","year":"2008","journal-title":"Science"},{"key":"2022072608130015000_DMM049612C23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/2211-5463.12382","article-title":"Effect of a neural relay on liver regeneration in mice: activation of serotonin release from the gastrointestinal tract","volume":"8","author":"Inoue","year":"2018","journal-title":"FEBS Open Bio."},{"key":"2022072608130015000_DMM049612C24","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1016\/j.ajpath.2011.07.014","article-title":"Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis","volume":"179","author":"Itoh","year":"2011","journal-title":"Am. J. Pathol."},{"key":"2022072608130015000_DMM049612C25","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.3748\/wjg.v24.i15.1616","article-title":"Autonomic nervous system network and liver regeneration","volume":"24","author":"Kamimura","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"2022072608130015000_DMM049612C26","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41593-019-0430-3","article-title":"Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression","volume":"22","author":"Kamiya","year":"2019","journal-title":"Nat. Neurosci."},{"key":"2022072608130015000_DMM049612C27","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"2022072608130015000_DMM049612C28","doi-asserted-by":"publisher","first-page":"dmm048922","DOI":"10.1242\/dmm.048922","article-title":"Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver","volume":"14","author":"Ko","year":"2021","journal-title":"Dis. Model Mech."},{"key":"2022072608130015000_DMM049612C29","doi-asserted-by":"publisher","first-page":"507","DOI":"10.2174\/1568026023393796","article-title":"Molecular biology of serotonin receptors - structure and function at the molecular level","volume":"2","author":"Kroeze","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"2022072608130015000_DMM049612C30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.pbb.2010.09.003","article-title":"Brain serotonin system in the coordination of food intake and body weight","volume":"97","author":"Lam","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"2022072608130015000_DMM049612C31","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Science"},{"key":"2022072608130015000_DMM049612C32","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.orcp.2016.03.015","article-title":"5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats","volume":"12","author":"Li","year":"2018","journal-title":"Obes. Res. Clin. Pract."},{"key":"2022072608130015000_DMM049612C33","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1210\/en.2016-1839","article-title":"The diverse metabolic roles of peripheral serotonin","volume":"158","author":"Martin","year":"2017","journal-title":"Endocrinology"},{"key":"2022072608130015000_DMM049612C34","doi-asserted-by":"publisher","first-page":"e13869","DOI":"10.1111\/nmo.13869","article-title":"Diet differentially regulates enterochromaffin cell serotonin content, density and nutrient sensitivity in the mouse small and large intestine","volume":"32","author":"Martin","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"2022072608130015000_DMM049612C35","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1002\/hep.32055","article-title":"Hepatic nervous system in development, regeneration, and disease","volume":"74","author":"Miller","year":"2021","journal-title":"Hepatology"},{"key":"2022072608130015000_DMM049612C36","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbrc.2011.03.133","article-title":"Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver","volume":"408","author":"Miyamura","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2022072608130015000_DMM049612C37","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/hepr.12760","article-title":"Autonomic nervous system and the liver","volume":"47","author":"Mizuno","year":"2017","journal-title":"Hepatol. Res."},{"key":"2022072608130015000_DMM049612C38","doi-asserted-by":"publisher","first-page":"e13799","DOI":"10.1111\/nmo.13799","article-title":"Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease","volume":"32","author":"Nagoya","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"2022072608130015000_DMM049612C39","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.14348\/molcells.2015.0258","article-title":"Peripheral serotonin: a new player in systemic energy homeostasis","volume":"38","author":"Namkung","year":"2015","journal-title":"Mol. Cells"},{"key":"2022072608130015000_DMM049612C40","doi-asserted-by":"publisher","first-page":"233","DOI":"10.4093\/dmj.2017.0084","article-title":"Inhibition of serotonin synthesis induces negative hepatic lipid balance","volume":"42","author":"Namkung","year":"2018","journal-title":"Diabetes Metab. J."},{"key":"2022072608130015000_DMM049612C41","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00535-016-1304-z","article-title":"Hepatic vagus nerve regulates Kupffer cell activation via \u03b17 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis","volume":"52","author":"Nishio","year":"2017","journal-title":"J. Gastroenterol."},{"key":"2022072608130015000_DMM049612C42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.bbrc.2012.05.115","article-title":"GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model","volume":"423","author":"Nishizawa","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2022072608130015000_DMM049612C43","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.3390\/ijms23031600","article-title":"The regulatory role of the central and peripheral serotonin network on feeding signals in metabolic diseases","volume":"23","author":"Nonogaki","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2022072608130015000_DMM049612C44","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1136\/gut.2003.026658","article-title":"Hepatic fibrogenesis requires sympathetic neurotransmitters","volume":"53","author":"Oben","year":"2004","journal-title":"Gut"},{"key":"2022072608130015000_DMM049612C45","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1148\/radiol.10101233","article-title":"Biopsy-proven nonsteatotic liver in adults: estimation of reference range for difference in attenuation between the liver and the spleen at nonenhanced CT","volume":"258","author":"Park","year":"2011","journal-title":"Radiology"},{"key":"2022072608130015000_DMM049612C46","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3803\/EnM.2021.1331","article-title":"Serotonergic regulation of hepatic energy metabolism","volume":"36","author":"Park","year":"2021","journal-title":"Endocrinol. Metab."},{"key":"2022072608130015000_DMM049612C47","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.jhep.2008.01.006","article-title":"The function of serotonin within the liver","volume":"48","author":"Ruddell","year":"2008","journal-title":"J. Hepatol."},{"key":"2022072608130015000_DMM049612C48","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1111\/obr.12308","article-title":"Non-alcoholic fatty liver disease as a consequence of autonomic imbalance and circadian desynchronization","volume":"16","author":"Sabath","year":"2015","journal-title":"Obes. Rev."},{"key":"2022072608130015000_DMM049612C49","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/hep.23412","article-title":"Insulin-like growth factor I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats","volume":"51","author":"Sobrevals","year":"2010","journal-title":"Hepatology"},{"key":"2022072608130015000_DMM049612C50","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s41586-020-2425-3","article-title":"The liver-brain-gut neural arc maintains the T(reg) cell niche in the gut","volume":"585","author":"Teratani","year":"2020","journal-title":"Nature"},{"key":"2022072608130015000_DMM049612C51","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"2022072608130015000_DMM049612C52","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/gutjnl-2019-320490","article-title":"Liver tissue microbiome in NAFLD: next step in understanding the gut-liver axis?","volume":"69","author":"Tilg","year":"2020","journal-title":"Gut"},{"key":"2022072608130015000_DMM049612C53","doi-asserted-by":"publisher","first-page":"e87478","DOI":"10.1371\/journal.pone.0087478","article-title":"Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model","volume":"9","author":"Valdivia","year":"2014","journal-title":"PLoS One"},{"key":"2022072608130015000_DMM049612C54","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cmet.2011.10.009","article-title":"NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways","volume":"14","author":"Vella","year":"2011","journal-title":"Cell Metab."},{"key":"2022072608130015000_DMM049612C55","first-page":"4995","article-title":"Image analysis of breast cancer immunohistochemistry-stained sections using ImageJ: an RGB-based model","volume":"29","author":"Vrekoussis","year":"2009","journal-title":"Anticancer Res."},{"key":"2022072608130015000_DMM049612C56","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3389\/fphar.2020.00553","article-title":"Gut-derived serotonin contributes to the progression of non-alcoholic steatohepatitis via the liver HTR2A\/PPAR\u03b32 pathway","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2022072608130015000_DMM049612C57","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1113\/jphysiol.2007.135996","article-title":"Afferent signalling through the common hepatic branch of the vagus inhibits voluntary lard intake and modifies plasma metabolite levels in rats","volume":"583","author":"Warne","year":"2007","journal-title":"J. Physiol."},{"key":"2022072608130015000_DMM049612C58","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.jhep.2017.05.007","article-title":"Targeting the gut-liver axis in liver disease","volume":"67","author":"Wiest","year":"2017","journal-title":"J. Hepatol."},{"key":"2022072608130015000_DMM049612C59","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1053\/j.gastro.2007.06.017","article-title":"Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors","volume":"133","author":"Wouters","year":"2007","journal-title":"Gastroenterology"},{"key":"2022072608130015000_DMM049612C60","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"2022072608130015000_DMM049612C61","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.acra.2012.02.022","article-title":"Computed tomography scans in the evaluation of fatty liver disease in a population-based study: the multiethnic study of atherosclerosis","volume":"19","author":"Zeb","year":"2012","journal-title":"Acad. Radiol."},{"key":"2022072608130015000_DMM049612C62","doi-asserted-by":"publisher","first-page":"978","DOI":"10.2174\/1389203721666200615171928","article-title":"Gut barrier protein S mediate liver regulation by the effects of serotonin on the non-alcoholic fatty liver","volume":"21","author":"Zhang","year":"2020","journal-title":"Protein Pept. Sci."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049612\/2150376\/dmm049612.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049612\/2154523\/dmm049612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049612\/2154523\/dmm049612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T08:13:19Z","timestamp":1658823199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/15\/7\/dmm049612\/276108\/Involvement-of-the-liver-gut-peripheral-neural"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.049612","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]},"article-number":"dmm049612"}}