{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:49:16Z","timestamp":1787021356495,"version":"build-2736575974"},"reference-count":85,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01NS104299"],"award-info":[{"award-number":["R01NS104299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32GM007315"],"award-info":[{"award-number":["T32GM007315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["F31NS100391"],"award-info":[{"award-number":["F31NS100391"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01NS128500"],"award-info":[{"award-number":["R01NS128500"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01MH112669"],"award-info":[{"award-number":["R01MH112669"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Down syndrome (DS) is caused by triplication of human chromosome 21 (HSA21). Although several HSA21 genes have been found to be responsible for aspects of DS, whether and how HSA21 genes interact with each other is poorly understood. DS patients and animal models present with a number of neurological changes, including aberrant connectivity and neuronal morphology. Previous studies have indicated that amyloid precursor protein (APP) and Down syndrome cell adhesion molecule (DSCAM) regulate neuronal morphology and contribute to neuronal aberrations in DS. Here, we report the functional interaction between the Drosophila homologs of these two genes, Amyloid precursor protein-like (Appl) and Dscam (Dscam1). We show that Appl requires Dscam to promote axon terminal growth in sensory neurons. Moreover, Appl increases Dscam protein expression post-transcriptionally. We further demonstrate that regulation of Dscam by Appl does not require the Appl intracellular domain or second extracellular domain. This study presents an example of functional interactions between HSA21 genes, providing insights into the pathogenesis of neuronal aberrations in DS.<\/jats:p>","DOI":"10.1242\/dmm.049725","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:35:39Z","timestamp":1694752539000},"source":"Crossref","is-referenced-by-count":7,"title":["The\n                    <i>Drosophila<\/i>\n                    homolog of\n                    <i>APP<\/i>\n                    promotes Dscam expression to drive axon terminal growth, revealing interaction between Down syndrome genes"],"prefix":"10.1242","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8959-6458","authenticated-orcid":false,"given":"Sarah","family":"Pizzano","sequence":"first","affiliation":[{"name":"Life Sciences Institute, University of Michigan 1 , Ann Arbor, MI 48109 , USA"},{"name":"University of Michigan 2 Neuroscience Graduate Program , , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-648X","authenticated-orcid":false,"given":"Gabriella R.","family":"Sterne","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan 1 , Ann Arbor, MI 48109 , USA"},{"name":"University of Michigan 2 Neuroscience Graduate Program , , Ann Arbor, MI 48109 , USA"},{"name":"University of Rochester Medical Center 3 Department of Biomedical Genetics , , Rochester, NY 14642 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-8724","authenticated-orcid":false,"given":"Macy W.","family":"Veling","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan 1 , Ann Arbor, MI 48109 , USA"},{"name":"University of Michigan 4 Cellular and Molecular Biology Program , , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Amanda","family":"Xu","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan 1 , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Hergenreder","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan 1 , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-4065","authenticated-orcid":false,"given":"Bing","family":"Ye","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan 1 , Ann Arbor, MI 48109 , USA"},{"name":"University of Michigan 2 Neuroscience Graduate Program , , Ann Arbor, MI 48109 , USA"},{"name":"University of Michigan 4 Cellular and Molecular Biology Program , , Ann Arbor, MI 48109 , USA"},{"name":"University of Michigan 5 Department of Cell and Developmental Biology , , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"2023091508350229700_DMM049725C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1203\/PDR.0b013e31811ead83","article-title":"Down syndrome cell adhesion molecule--a common determinant of brain and heart wiring","volume":"62","author":"Baumann","year":"2007","journal-title":"Pediatr. Res."},{"key":"2023091508350229700_DMM049725C2","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"2023091508350229700_DMM049725C3","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1073\/pnas.1618606114","article-title":"DSCAM promotes axon fasciculation and growth in the developing optic pathway","volume":"114","author":"Bruce","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C4","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/0092-8674(93)90732-6","article-title":"Axis specification in the developing Drosophila appendage: the role of wingless, decapentaplegic, and the homeobox gene aristaless","volume":"74","author":"Campbell","year":"1993","journal-title":"Cell"},{"key":"2023091508350229700_DMM049725C5","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/bdra.20294","article-title":"National estimates and race\/ethnic-specific variation of selected birth defects in the United States, 1999-2001","volume":"76","author":"Canfield","year":"2006","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"2023091508350229700_DMM049725C6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1126\/science.1058783","article-title":"A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"2023091508350229700_DMM049725C7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.2353\/ajpath.2008.071053","article-title":"Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects","volume":"173","author":"Cataldo","year":"2008","journal-title":"Am. J. Pathol."},{"key":"2023091508350229700_DMM049725C8","doi-asserted-by":"publisher","first-page":"6788","DOI":"10.1523\/JNEUROSCI.23-17-06788.2003","article-title":"App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome","volume":"23","author":"Cataldo","year":"2003","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C9","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/s12035-012-8310-9","article-title":"Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis","volume":"46","author":"Cattaneo","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"2023091508350229700_DMM049725C10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00726-002-0336-2","article-title":"Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part I)","volume":"24","author":"Cheon","year":"2003","journal-title":"Amino Acids"},{"key":"2023091508350229700_DMM049725C11","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/j.1365-2788.2006.00842.x","article-title":"Dementia and mortality in persons with Down's syndrome","volume":"50","author":"Coppus","year":"2006","journal-title":"J. Intellect. Disabil. Res."},{"key":"2023091508350229700_DMM049725C12","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.1073\/pnas.0911326107","article-title":"Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein","volume":"107","author":"Dahms","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023091508350229700_DMM049725C13","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3233\/JAD-160836","article-title":"Down syndrome, partial trisomy 21, and absence of Alzheimer's disease: the role of APP","volume":"56","author":"Doran","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"2023091508350229700_DMM049725C14","doi-asserted-by":"publisher","first-page":"13703","DOI":"10.1073\/pnas.95.23.13703","article-title":"Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype","volume":"95","author":"Fossgreen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0092-8674(00)81341-0","article-title":"Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics","volume":"87","author":"Gertler","year":"1996","journal-title":"Cell"},{"key":"2023091508350229700_DMM049725C16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0092-8674(91)90571-F","article-title":"Genetic-analysis of growth cone guidance in drosophila - fasciclin-ii functions as a neuronal recognition molecule","volume":"67","author":"Grenningloh","year":"1991","journal-title":"Cell"},{"key":"2023091508350229700_DMM049725C17","doi-asserted-by":"publisher","first-page":"e1002344","DOI":"10.1371\/journal.pgen.1002344","article-title":"Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects","volume":"7","author":"Grossman","year":"2011","journal-title":"PLoS Genet."},{"key":"2023091508350229700_DMM049725C18","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/S0960-9822(03)00207-0","article-title":"Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion","volume":"13","author":"Grueber","year":"2003","journal-title":"Curr. Biol."},{"key":"2023091508350229700_DMM049725C19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1242\/dev.02666","article-title":"Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology","volume":"134","author":"Grueber","year":"2007","journal-title":"Development"},{"key":"2023091508350229700_DMM049725C20","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.celrep.2014.10.020","article-title":"The role of PPK26 in Drosophila larval mechanical nociception","volume":"9","author":"Guo","year":"2014","journal-title":"Cell Rep"},{"key":"2023091508350229700_DMM049725C21","first-page":"398","article-title":"beta-Amyloid, protein processing and Alzheimer's disease","volume":"45","author":"Haas","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"2023091508350229700_DMM049725C22","doi-asserted-by":"publisher","first-page":"9673","DOI":"10.1073\/pnas.1106386108","article-title":"Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila","volume":"108","author":"Han","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1755-5949.2010.00221.x","article-title":"The upside of APP at synapses","volume":"18","author":"Hoe","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"2023091508350229700_DMM049725C24","doi-asserted-by":"publisher","first-page":"7459","DOI":"10.1523\/JNEUROSCI.4872-08.2009","article-title":"Interaction of reelin with amyloid precursor protein promotes neurite outgrowth","volume":"29","author":"Hoe","year":"2009","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C25","doi-asserted-by":"publisher","first-page":"12712","DOI":"10.1073\/pnas.2135347100","article-title":"Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture","volume":"100","author":"Hong","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C26","doi-asserted-by":"publisher","first-page":"100415","DOI":"10.1016\/j.crmeth.2023.100415","article-title":"LabGym: Quantification of user-defined animal behaviors using learning-based holistic assessment","volume":"3","author":"Hu","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"2023091508350229700_DMM049725C27","doi-asserted-by":"publisher","first-page":"4896","DOI":"10.1016\/j.cub.2020.09.045","article-title":"A neural basis for categorizing sensory stimuli to enhance decision accuracy","volume":"30","author":"Hu","year":"2020","journal-title":"Curr. Biol."},{"key":"2023091508350229700_DMM049725C28","doi-asserted-by":"publisher","first-page":"9439","DOI":"10.1073\/pnas.89.20.9439","article-title":"Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage","volume":"89","author":"Hung","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C29","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.cub.2007.11.029","article-title":"Nociceptive neurons protect Drosophila larvae from parasitoid wasps","volume":"17","author":"Hwang","year":"2007","journal-title":"Curr. Biol."},{"key":"2023091508350229700_DMM049725C30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0896-6273(03)00631-7","article-title":"The control of dendrite development","volume":"40","author":"Jan","year":"2003","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C31","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1352\/0047-6765(2000)038&lt;0276:PODAIO&gt;2.0.CO;2","article-title":"Prevalence of dementia and impact on intellectual disability services","volume":"38","author":"Janicki","year":"2000","journal-title":"Ment. Retard."},{"key":"2023091508350229700_DMM049725C32","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.neuron.2017.06.034","article-title":"Serotonergic modulation enables pathway-specific plasticity in a developing sensory circuit in drosophila","volume":"95","author":"Kaneko","year":"2017","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C33","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/0006-291X(90)90992-V","article-title":"Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain","volume":"166","author":"Kang","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023091508350229700_DMM049725C34","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.neuron.2013.05.020","article-title":"Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons","volume":"78","author":"Kim","year":"2013","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nature10801","article-title":"The role of Drosophila Piezo in mechanical nociception","volume":"483","author":"Kim","year":"2012","journal-title":"Nature"},{"key":"2023091508350229700_DMM049725C36","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.1523\/JNEUROSCI.1673-12.2012","article-title":"Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists","volume":"32","author":"Kleschevnikov","year":"2012","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C37","doi-asserted-by":"publisher","first-page":"8153","DOI":"10.1523\/JNEUROSCI.1766-04.2004","article-title":"Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome","volume":"24","author":"Kleschevnikov","year":"2004","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C38","doi-asserted-by":"publisher","first-page":"4748","DOI":"10.1073\/pnas.90.10.4748","article-title":"Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth","volume":"90","author":"Koo","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C39","doi-asserted-by":"publisher","first-page":"12031","DOI":"10.1073\/pnas.0813248106","article-title":"The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies","volume":"106","author":"Korbel","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C40","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.1074\/jbc.270.8.3565","article-title":"Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain","volume":"270","author":"Lai","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2023091508350229700_DMM049725C41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C42","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1038\/sj.emboj.7600757","article-title":"Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain","volume":"24","author":"Leyssen","year":"2005","journal-title":"EMBO J."},{"key":"2023091508350229700_DMM049725C43","doi-asserted-by":"publisher","first-page":"e3002078","DOI":"10.1371\/journal.pbio.3002078","article-title":"DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models","volume":"21","author":"Liu","year":"2023","journal-title":"PLoS Biol."},{"key":"2023091508350229700_DMM049725C44","doi-asserted-by":"publisher","first-page":"641152","DOI":"10.3389\/fcell.2021.641152","article-title":"Association analysis of variants of DSCAM and BACE2 with hirschsprung disease susceptibility in han chinese and functional evaluation in zebrafish","volume":"9","author":"Lu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2023091508350229700_DMM049725C45","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0896-6273(92)90024-8","article-title":"Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene","volume":"9","author":"Luo","year":"1992","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C46","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.brainres.2007.05.050","article-title":"Expression of APP pathway mRNAs and proteins in Alzheimer's disease","volume":"1161","author":"Matsui","year":"2007","journal-title":"Brain Res."},{"key":"2023091508350229700_DMM049725C47","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1242\/dmm.012104","article-title":"Synaptic abnormalities in a Drosophila model of Alzheimer's disease","volume":"7","author":"Mhatre","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"2023091508350229700_DMM049725C48","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1091\/mbc.e06-04-0283","article-title":"Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)","volume":"18","author":"M\u00fcller","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"2023091508350229700_DMM049725C49","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1126\/science.1114535","article-title":"An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes","volume":"309","author":"O'Doherty","year":"2005","journal-title":"Science"},{"key":"2023091508350229700_DMM049725C50","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1074\/jbc.270.9.4205","article-title":"Ligand-dependent G-protein coupling function of amyloid transmembrane precursor","volume":"270","author":"Okamoto","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2023091508350229700_DMM049725C51","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.neuron.2016.01.042","article-title":"Down syndrome developmental brain transcriptome reveals defective oligodendrocyte differentiation and myelination","volume":"89","author":"Olmos-Serrano","year":"2016","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C52","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1046\/j.1471-4159.1994.62031062.x","article-title":"Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination","volume":"62","author":"Oyama","year":"1994","journal-title":"J. Neurochem."},{"key":"2023091508350229700_DMM049725C53","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0027-5107(88)90229-1","article-title":"The nature of N\u2013ethyl\u2013N\u2013nitrosourea\u2013induced mutations at the white locus of Drosophila melanogaster","volume":"199","author":"Pastink","year":"1988","journal-title":"Mutat. Res."},{"key":"2023091508350229700_DMM049725C54","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1523\/JNEUROSCI.15-03-02157.1995","article-title":"Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner","volume":"15","author":"Qiu","year":"1995","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C55","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0169-328X(97)00045-4","article-title":"Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes","volume":"47","author":"Rohan de Silva","year":"1997","journal-title":"Brain Res. Mol. Brain Res."},{"key":"2023091508350229700_DMM049725C56","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1073\/pnas.86.7.2478","article-title":"A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor","volume":"86","author":"Rosen","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023091508350229700_DMM049725C57","doi-asserted-by":"publisher","first-page":"5407","DOI":"10.1523\/JNEUROSCI.23-13-05407.2003","article-title":"The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo","volume":"23","author":"Sabo","year":"2003","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C58","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/s004010000230","article-title":"The developmental and aging changes of Down's syndrome cell adhesion molecule expression in normal and Down's syndrome brains","volume":"100","author":"Saito","year":"2000","journal-title":"Acta Neuropathol."},{"key":"2023091508350229700_DMM049725C59","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuron.2006.05.022","article-title":"Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration","volume":"51","author":"Salehi","year":"2006","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C60","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1074\/jbc.M108357200","article-title":"Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)","volume":"277","author":"Scheinfeld","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2023091508350229700_DMM049725C61","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0092-8674(00)80878-8","article-title":"Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity","volume":"101","author":"Schmucker","year":"2000","journal-title":"Cell"},{"key":"2023091508350229700_DMM049725C62","doi-asserted-by":"publisher","first-page":"6723","DOI":"10.1523\/JNEUROSCI.1517-07.2007","article-title":"specific drosophila dscam juxtamembrane variants control dendritic elaboration and axonal Arborization","volume":"27","author":"Shi","year":"2007","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C63","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1046\/j.1440-169X.1996.00012.x","article-title":"A nuclear GFP\/ beta-galactosidase fusion protein as a marker for morphogenesis in living Drosophila","volume":"38","author":"Shiga","year":"1996","journal-title":"Dev. Growth Differ."},{"key":"2023091508350229700_DMM049725C64","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1523\/JNEUROSCI.14-04-02117.1994","article-title":"A heparin-binding domain in the amyloid protein-precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth","volume":"14","author":"Small","year":"1994","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C65","doi-asserted-by":"publisher","first-page":"e1001562","DOI":"10.1371\/journal.pbio.1001562","article-title":"The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling","volume":"11","author":"Soldano","year":"2013","journal-title":"PLoS Biol."},{"key":"2023091508350229700_DMM049725C66","doi-asserted-by":"publisher","first-page":"e05196","DOI":"10.7554\/eLife.05196","article-title":"Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors","volume":"4","author":"Sterne","year":"2015","journal-title":"eLife"},{"key":"2023091508350229700_DMM049725C67","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0960-9822(99)80215-2","article-title":"Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport","volume":"9","author":"Torroja","year":"1999","journal-title":"Curr. Biol."},{"key":"2023091508350229700_DMM049725C68","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1523\/JNEUROSCI.16-15-04638.1996","article-title":"APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons","volume":"16","author":"Torroja","year":"1996","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C69","doi-asserted-by":"publisher","first-page":"7793","DOI":"10.1523\/JNEUROSCI.19-18-07793.1999","article-title":"The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction","volume":"19","author":"Torroja","year":"1999","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C70","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0092-8674(03)00272-1","article-title":"painless, a Drosophila gene essential for nociception","volume":"113","author":"Tracey","year":"2003","journal-title":"Cell"},{"key":"2023091508350229700_DMM049725C71","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.neuron.2004.06.033","article-title":"Transmembrane\/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis","volume":"43","author":"Wang","year":"2004","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C72","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0896-6273(02)00570-6","article-title":"Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons","volume":"33","author":"Wang","year":"2002","journal-title":"Neuron"},{"key":"2023091508350229700_DMM049725C73","doi-asserted-by":"publisher","first-page":"e1001572","DOI":"10.1371\/journal.pbio.1001572","article-title":"Bimodal control of dendritic and axonal growth by the dual leucine zipper kinase pathway","volume":"11","author":"Wang","year":"2013","journal-title":"PLoS Biol."},{"key":"2023091508350229700_DMM049725C74","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.1074\/jbc.274.9.5823","article-title":"Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases","volume":"274","author":"Weidemann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023091508350229700_DMM049725C75","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1093\/brain\/awy159","article-title":"Trisomy of human chromosome 21 enhances amyloid-\u03b2 deposition independently of an extra copy of APP","volume":"141","author":"Wiseman","year":"2018","journal-title":"Brain"},{"key":"2023091508350229700_DMM049725C76","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","article-title":"Analysis of genetic mosaics in developing and adult Drosophila tissues","volume":"117","author":"Xu","year":"1993","journal-title":"Development"},{"key":"2023091508350229700_DMM049725C77","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1172\/JCI82409","article-title":"Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration","volume":"126","author":"Xu","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2023091508350229700_DMM049725C78","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1523\/JNEUROSCI.6307-10.2011","article-title":"Differential regulation of dendritic and axonal development by the novel Kr\u00fcppel-like factor Dar1","volume":"31","author":"Ye","year":"2011","journal-title":"J. Neurosci."},{"key":"2023091508350229700_DMM049725C79","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1749-8104-3-15","article-title":"Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1","volume":"3","author":"Young-Pearse","year":"2008","journal-title":"Neural Dev."},{"key":"2023091508350229700_DMM049725C80","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0092-8674(01)00589-X","article-title":"Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function","volume":"107","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"2023091508350229700_DMM049725C81","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1021\/bi027117f","article-title":"The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway","volume":"42","author":"Zhao","year":"2003","journal-title":"Biochemistry"},{"key":"2023091508350229700_DMM049725C82","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.celrep.2011.11.002","article-title":"Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel","volume":"1","author":"Zhong","year":"2012","journal-title":"Cell Rep."},{"key":"2023091508350229700_DMM049725C83","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1126\/science.8310297","article-title":"Paralysis and early death in cysteine string protein mutants of Drosophila","volume":"263","author":"Zinsmaier","year":"1994","journal-title":"Science"},{"key":"2023091508350229700_DMM049725C84","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1146\/annurev-neuro-062111-150414","article-title":"The molecular basis of self-avoidance","volume":"36","author":"Zipursky","year":"2013","journal-title":"Annu. Rev. Neurosci."},{"key":"2023091508350229700_DMM049725C85","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cell.2010.10.009","article-title":"Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly","volume":"143","author":"Zipursky","year":"2010","journal-title":"Cell"}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049725\/3145102\/dmm049725.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049725\/3145102\/dmm049725.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:35:43Z","timestamp":1694752543000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/16\/9\/dmm049725\/328130\/The-Drosophila-homolog-of-APP-promotes-Dscam"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.049725","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]},"article-number":"dmm049725"}}