{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:04:44Z","timestamp":1753884284444,"version":"3.41.2"},"reference-count":22,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Brain diseases are a major cause of death and disability worldwide and contribute significantly to years of potential life lost. Although there have been considerable advances in biological mechanisms associated with brain disorders as well as drug discovery paradigms in recent years, these have not been sufficiently translated into effective treatments. This Special Article expands on Keystone Symposia's pre- and post-pandemic panel discussions on translational neuroscience research. In the article, we discuss how lessons learned from the COVID-19 pandemic can catalyze critical progress in translational research, with efficient collaboration bridging the gap between basic discovery and clinical application. To achieve this, we must place patients at the center of the research paradigm. Furthermore, we need commitment from all collaborators to jointly mitigate the risk associated with the research process. This will require support from investors, the public sector and pharmaceutical companies to translate disease mechanisms into world-class drugs. We also discuss the role of scientific publishing in supporting these models of open innovation. Open science journals can now function as hubs to accelerate progress from discovery to treatments, in neuroscience in particular, making this process less tortuous by bringing scientists together and enabling them to exchange data, tools and knowledge effectively. As stakeholders from a broad range of scientific professions, we feel an urgency to advance brain disease therapies and encourage readers to work together in tackling this challenge.<\/jats:p>","DOI":"10.1242\/dmm.049755","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T14:09:15Z","timestamp":1671631755000},"source":"Crossref","is-referenced-by-count":0,"title":["Collaboration and knowledge integration for successful brain therapeutics \u2013 lessons learned from the pandemic"],"prefix":"10.1242","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-0863","authenticated-orcid":false,"given":"Maria Isabel","family":"Loza","sequence":"first","affiliation":[{"name":"Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Pharmacology Department, School of Pharmacy, University of Santiago de Compostela, Health Research Institute (IDIS), K\u00e6rtor Foundation 1 , 15706 Santiago de Compostela , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-8000","authenticated-orcid":false,"given":"Julija","family":"Hmeljak","sequence":"additional","affiliation":[{"name":"The Company of Biologists 2 Disease Models & Mechanisms , , Bidder Building, Station Road, Histon, Cambridge CB24 9LF , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chas","family":"Bountra","sequence":"additional","affiliation":[{"name":"Dorothy Crowfoot Hodgkin Building, Dorothy Hodgkin Road, University of Oxford 3 , Oxford OX1 3QU , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Audia","sequence":"additional","affiliation":[{"name":"Flare Therapeutics 4 , 215 1st Street, Cambridge, MA, 02142 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohini","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"The Michael J. Fox Foundation for Parkinson's Research 5 , 111 West 33 Street, New York, NY 10120 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Weiman","sequence":"additional","affiliation":[{"name":"Keystone Symposia, 160 U.S. Highway 6, Suite 201, PO Box 1630, Silverthorne, CO 80498, USA 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9403","authenticated-orcid":false,"given":"Kalpana","family":"Merchant","sequence":"additional","affiliation":[{"name":"Northwestern University 7 , 303 E Chicago Ave., Chicago, IL 60611 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4333-365X","authenticated-orcid":false,"given":"Maria-Jesus","family":"Blanco","sequence":"additional","affiliation":[{"name":"Atavistik Bio 8 , 38 Sidney Street, Cambridge MA 02139 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"2022122114091229000_DMM049755C1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-3-030-86495-8_4","article-title":"Integrating neurologic and psychiatric perspectives in functional movement disorder","volume-title":"Functional Movement Disorder. Current Clinical Neurology","author":"Anderson","year":"2022"},{"key":"2022122114091229000_DMM049755C2","doi-asserted-by":"publisher","first-page":"e001764","DOI":"10.1136\/bmjopen-2012-001764","article-title":"The natural history of early-onset dementia: the Artemis Project","volume":"2012","author":"Atkins","year":"2012","journal-title":"BMJ Open"},{"key":"2022122114091229000_DMM049755C3","doi-asserted-by":"publisher","first-page":"e1009224","DOI":"10.1371\/journal.pgen.1009224","article-title":"Gaunt TR; AMP-AD eQTL working group. Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome","volume":"17","author":"Baird","year":"2021","journal-title":"PLoS Genet."},{"key":"2022122114091229000_DMM049755C4","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.molmed.2021.05.004","article-title":"mRNA therapeutics: beyond vaccine applications","volume":"27","author":"Bhat","year":"2021","journal-title":"Trends Mol. Med."},{"key":"2022122114091229000_DMM049755C5","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"2022122114091229000_DMM049755C7","doi-asserted-by":"publisher","first-page":"e1605","DOI":"10.1212\/WNL.0000000000008359","article-title":"Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers","volume":"93","author":"Cammack","year":"2019","journal-title":"Neurology"},{"key":"2022122114091229000_DMM049755C8","doi-asserted-by":"publisher","first-page":"dmm041434","DOI":"10.1242\/dmm.041434","article-title":"Translational medicine in neuromuscular disorders: from academia to industry","volume":"13","author":"Cowling","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"2022122114091229000_DMM049755C9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-022-00282-2","article-title":"Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures","volume":"8","author":"Dhanwani","year":"2022","journal-title":"npj Parkinsons Dis."},{"key":"2022122114091229000_DMM049755C10","doi-asserted-by":"publisher","first-page":"dmm048983","DOI":"10.1242\/dmm.048983","article-title":"(Dis)Solving the problem of aberrant protein states","volume":"14","author":"Fare","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"2022122114091229000_DMM049755C11","doi-asserted-by":"publisher","first-page":"114228","DOI":"10.1016\/j.psychres.2021.114228","article-title":"Suicide, self-harm and suicidal ideation during COVID-19: A systematic review","volume":"306","author":"Farooq","year":"2021","journal-title":"Psychiatry Res."},{"key":"2022122114091229000_DMM049755C12","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1186\/s12888-020-02749-z","article-title":"Trends in psychiatric diagnoses, medications and psychological therapies in a large Swedish region: a population-based study","volume":"20","author":"Forlund","year":"2020","journal-title":"BMC Psychiatry"},{"key":"2022122114091229000_DMM049755C13","doi-asserted-by":"publisher","first-page":"113264","DOI":"10.1016\/j.psychres.2020.113264","article-title":"Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown","volume":"291","author":"Guessoum","year":"2020","journal-title":"Psychiatry Res."},{"key":"2022122114091229000_DMM049755C14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3233\/JPD-202038","article-title":"The impact of the COVID-19 pandemic on Parkinson's disease: hidden sorrows and emerging opportunities","volume":"10","author":"Helmich","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"2022122114091229000_DMM049755C15","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s00213-021-05838-3","article-title":"Challenges in CNS drug development and the role of imaging","volume":"238","author":"Howes","year":"2021","journal-title":"Psychopharmacology"},{"key":"2022122114091229000_DMM049755C16","doi-asserted-by":"publisher","first-page":"dmm049010","DOI":"10.1242\/dmm.049010","article-title":"Caenorhabditis elegans for rare disease modeling and drug discovery: strategies and strengths","volume":"14","author":"Kropp","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"2022122114091229000_DMM049755C17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jpsychires.2019.08.002","article-title":"Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burden of Disease study","volume":"126","author":"Liu","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"2022122114091229000_DMM049755C18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41398-020-0827-5","article-title":"Drug repositioning for psychiatric and neurological disorders through a network medicine approach","volume":"10","author":"L\u00fcscher Dias","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"2022122114091229000_DMM049755C19","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/alz.12143","article-title":"Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future","volume":"16","author":"Mok","year":"2020","journal-title":"Alzheimers Dement."},{"key":"2022122114091229000_DMM049755C20","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.2174\/1381612826666200224112534","article-title":"Drug development for central nervous system diseases using in vitro blood-brain barrier models and drug repositioning","volume":"26","author":"Morofuji","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"2022122114091229000_DMM049755C21","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1056\/NEJMc1504261","article-title":"Trends in Mental Health Care among Children and Adolescents","volume":"373","author":"Olfson","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2022122114091229000_DMM049755C22","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1017\/S0033583520000025","article-title":"Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases","volume":"49","author":"Sinnige","year":"2020","journal-title":"Q. Rev. Biophys."},{"key":"2022122114091229000_DMM049755C23","doi-asserted-by":"publisher","first-page":"dmm049549","DOI":"10.1242\/dmm.049549","article-title":"The power of Drosophila in modeling human disease mechanisms","volume":"15","author":"Verheyen","year":"2022","journal-title":"Dis. Model. Mech."}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049755\/2392838\/dmm049755.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049755\/2392838\/dmm049755.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T14:09:18Z","timestamp":1671631758000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/15\/12\/dmm049755\/286134\/Collaboration-and-knowledge-integration-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.049755","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"type":"print","value":"1754-8403"},{"type":"electronic","value":"1754-8411"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"article-number":"dmm049755"}}