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The risk of CHIKV transmission is rising due to increased global interactions, year-round presence of mosquito vectors, and the ability of CHIKV to produce high host viral loads and undergo mutation. Although CHIKV disease is rarely fatal, it can progress to a chronic stage, during which patients experience severe debilitating arthritis that can last from several weeks to months or years. At present, there are no licensed vaccines or antiviral drugs for CHIKV disease, and treatment is primarily symptomatic. This Review provides an overview of CHIKV pathogenesis and explores the available therapeutic options and the most recent advances in novel therapeutic strategies against CHIKV infections.<\/jats:p>","DOI":"10.1242\/dmm.049804","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T12:02:20Z","timestamp":1680609740000},"source":"Crossref","is-referenced-by-count":16,"title":["Evolution and immunopathology of chikungunya virus informs therapeutic development"],"prefix":"10.1242","volume":"16","author":[{"given":"Filipa","family":"Henderson Sousa","sequence":"first","affiliation":[{"name":"School of Applied Sciences, Edinburgh Napier University 1 , Sighthill Campus, Edinburgh EH11 4BN , UK"},{"name":"Centre for Discovery Brain Sciences and UK Dementia Research Institute, The University of Edinburgh 2 , Edinburgh EH16 4SB , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalina","family":"Ghaisani Komarudin","sequence":"additional","affiliation":[{"name":"Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Cibinong Science Center, Cibinong, Kabupaten Bogor 16911 3 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-9077","authenticated-orcid":false,"given":"Fern","family":"Findlay-Greene","sequence":"additional","affiliation":[{"name":"School of Applied Sciences, Edinburgh Napier University 1 , Sighthill Campus, Edinburgh EH11 4BN , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-1460","authenticated-orcid":false,"given":"Anom","family":"Bowolaksono","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Mechanisms in Biological System (CEMBIOS) Research Group 4 , Department of Biology, Faculty of Mathematics and Natural Sciences , , Depok 16424 , Indonesia"},{"name":"Universitas Indonesia 4 , Department of Biology, Faculty of Mathematics and Natural Sciences , , Depok 16424 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-2590","authenticated-orcid":false,"given":"R. 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