{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:39:10Z","timestamp":1790674750613,"version":"4.1.0"},"reference-count":43,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"crossref","award":["2020ELYA32"],"award-info":[{"award-number":["2020ELYA32"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007423","name":"Duchenne Parent Project","doi-asserted-by":"crossref","award":["22.004"],"award-info":[{"award-number":["22.004"]}],"id":[{"id":"10.13039\/501100007423","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007074","name":"Fondazione CON IL SUD","doi-asserted-by":"crossref","award":["2018-PDR-00351"],"award-info":[{"award-number":["2018-PDR-00351"]}],"id":[{"id":"10.13039\/501100007074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"crossref","award":["AIM1801289-2"],"award-info":[{"award-number":["AIM1801289-2"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The potential role of liver kinase B1 (LKB1) in the altered activation of the master metabolic and epigenetic regulator adenosine monophosphate-activated protein kinase (AMPK) in Duchenne muscular dystrophy has not been investigated so far. Hence, we analyzed both gene and protein levels of LKB1 and its related targets in gastrocnemius muscles of adult C57BL\/10 mdx mice and D2 mdx mice, a model with a more severe dystrophic phenotype, as well as the sensitivity of the LKB1\u2013AMPK pathway to AMPK activators, such as chronic exercise. Our data show, for the first time, a reduction in the levels of LKB1 and accessory proteins, MO25 and STRAD\u03b1, in both mdx strains versus the respective wild type, which was further impaired by exercise, in parallel with a lack of further phosphorylation of AMPK. The AMPK-like kinase salt-inducible kinase (SIK) and class II histone deacetylases, along with expression of the HDAC target gene Mef2c, were also altered, supporting an impairment of LKB1-SIK-class II histone deacetylase signaling. Our results demonstrate that LKB1 may be involved in dystrophic progression, paving the way for future preclinical studies.<\/jats:p>","DOI":"10.1242\/dmm.049930","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T04:04:50Z","timestamp":1688961890000},"source":"Crossref","is-referenced-by-count":17,"title":["LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model"],"prefix":"10.1242","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-8490","authenticated-orcid":false,"given":"Brigida","family":"Boccanegra","sequence":"first","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-2222","authenticated-orcid":false,"given":"Paola","family":"Mantuano","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-5125","authenticated-orcid":false,"given":"Elena","family":"Conte","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Giovanni","family":"Cerchiara","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisamaura","family":"Tulimiero","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Quarta","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Caputo","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sanarica","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Forino","sequence":"additional","affiliation":[{"name":"Italfarmaco S.p.A. 2 Preclinical R&D Department , , Cinisello Balsamo, 20092 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Spadotto","sequence":"additional","affiliation":[{"name":"Italfarmaco S.p.A. 2 Preclinical R&D Department , , Cinisello Balsamo, 20092 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-3502","authenticated-orcid":false,"given":"Ornella","family":"Cappellari","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-5822","authenticated-orcid":false,"given":"Gianluca","family":"Fossati","sequence":"additional","affiliation":[{"name":"Italfarmaco S.p.A. 2 Preclinical R&D Department , , Cinisello Balsamo, 20092 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-9699","authenticated-orcid":false,"given":"Christian","family":"Steink\u00fchler","sequence":"additional","affiliation":[{"name":"Italfarmaco S.p.A. 2 Preclinical R&D Department , , Cinisello Balsamo, 20092 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-7341","authenticated-orcid":false,"given":"Annamaria","family":"De Luca","sequence":"additional","affiliation":[{"name":"University of Bari \u2018Aldo Moro\u2019 1 Department of Pharmacy-Drug Sciences , , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"2023080307334089300_DMM049930C1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nm1573","article-title":"SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes","volume":"13","author":"Berdeaux","year":"2007","journal-title":"Nat. Med."},{"key":"2023080307334089300_DMM049930C2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.nmd.2016.07.002","article-title":"Histological effects of givinostat in boys with Duchenne muscular dystrophy","volume":"26","author":"Bettica","year":"2016","journal-title":"Neuromuscul. Disord."},{"key":"2023080307334089300_DMM049930C3","doi-asserted-by":"publisher","first-page":"5102","DOI":"10.1093\/emboj\/cdg490","article-title":"MO25\/interact with STRAD\/enhancing their ability to bind, activate and localize LKB1 in the cytoplasm","volume":"22","author":"Boudeau","year":"2003","journal-title":"EMBO J."},{"key":"2023080307334089300_DMM049930C4","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/hmg\/ddu287","article-title":"Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical-metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy","volume":"23","author":"Camerino","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2023080307334089300_DMM049930C5","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1152\/japplphysiol.00776.2015","article-title":"Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points","volume":"122","author":"Capogrosso","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"2023080307334089300_DMM049930C6","doi-asserted-by":"publisher","first-page":"e41574","DOI":"10.1371\/journal.pone.0041574","article-title":"Micro-RNA-195 and -451 regulate the LKB1\/AMPK signaling axis by targeting MO25","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS ONE"},{"key":"2023080307334089300_DMM049930C7","doi-asserted-by":"publisher","first-page":"165805","DOI":"10.1016\/j.bbadis.2020.165805","article-title":"Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance","volume":"1866","author":"Chen","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"2023080307334089300_DMM049930C8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/hmg\/ddv460","article-title":"Effect of genetic background on the dystrophic phenotype in mdx mice","volume":"25","author":"Coley","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"2023080307334089300_DMM049930C9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2119\/molmed.2011.00049","article-title":"Histone deacetylase inhibitors in the treatment of muscular dystrophies: epigenetic drugs for genetic diseases","volume":"17","author":"Consalvi","year":"2011","journal-title":"Mol. Med."},{"key":"2023080307334089300_DMM049930C10","doi-asserted-by":"publisher","first-page":"15747","DOI":"10.1038\/ncomms15747","article-title":"Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression","volume":"8","author":"Dogliotti","year":"2017","journal-title":"Nat. Commun."},{"key":"2023080307334089300_DMM049930C11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-021-00248-3","article-title":"Duchenne muscular dystrophy","volume":"7","author":"Duan","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2023080307334089300_DMM049930C12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13395-015-0041-y","article-title":"Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia","volume":"5","author":"Duddy","year":"2015","journal-title":"Skelet. Muscle"},{"key":"2023080307334089300_DMM049930C13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/2044-5040-4-10","article-title":"Myofiber branching rather than myofiber hyperplasia contributes to muscle hypertrophy in mdx mice","volume":"4","author":"Faber","year":"2014","journal-title":"Skelet. Muscle"},{"key":"2023080307334089300_DMM049930C14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jprot.2017.09.009","article-title":"Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds","volume":"170","author":"Gamberi","year":"2018","journal-title":"J. Proteomics"},{"key":"2023080307334089300_DMM049930C15","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1002\/cphy.c140048","article-title":"The Dystrophin Complex: structure, function and implications for therapy","volume":"5","author":"Gao","year":"2015","journal-title":"Compr. Physiol."},{"key":"2023080307334089300_DMM049930C16","doi-asserted-by":"publisher","first-page":"105751","DOI":"10.1016\/j.phrs.2021.105751","article-title":"Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy","volume":"170","author":"Giovarelli","year":"2021","journal-title":"Pharmacol. Res."},{"key":"2023080307334089300_DMM049930C17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2008.03.008","article-title":"Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy","volume":"31","author":"Grounds","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"2023080307334089300_DMM049930C18","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1152\/japplphysiol.00885.2005","article-title":"Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice","volume":"100","author":"Hancock","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"2023080307334089300_DMM049930C19","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1093\/hmg\/ddu366","article-title":"Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients","volume":"23","author":"Hathout","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2023080307334089300_DMM049930C20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1475-4924-2-28","article-title":"Complexes between the LKB1 tumor suppressor, STRAD alpha\/beta and MO25 alpha\/beta are upstream kinases in the AMP-activated protein kinase cascade","volume":"2","author":"Hawley","year":"2003","journal-title":"J. Biol."},{"key":"2023080307334089300_DMM049930C21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023080307334089300_DMM049930C22","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.2337\/db12-1160","article-title":"LKB1 regulates lipid oxidation during exercise independently of AMPK","volume":"62","author":"Jeppesen","year":"2013","journal-title":"Diabetes"},{"key":"2023080307334089300_DMM049930C23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2023080307334089300_DMM049930C24","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1","volume":"23","author":"Lizcano","year":"2004","journal-title":"EMBO J."},{"key":"2023080307334089300_DMM049930C25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bcp.2018.04.022","article-title":"Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy","volume":"154","author":"Mantuano","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"2023080307334089300_DMM049930C26","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.3390\/nu12082295","article-title":"Ergogenic effect of BCAAs and L-alanine supplementation: proof-of-concept study in a murine model of physiological exercise","volume":"12","author":"Mantuano","year":"2020","journal-title":"Nutrients"},{"key":"2023080307334089300_DMM049930C27","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3390\/biom11111742","article-title":"\u03b2-dystroglycan restoration and pathology progression in the dystrophic mdx mouse: outcome and implication of a clinically oriented study with a novel oral dasatinib formulation","volume":"11","author":"Mantuano","year":"2021","journal-title":"Biomolecules"},{"key":"2023080307334089300_DMM049930C28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1440-1681.2009.05311.x","article-title":"Histone modifications and skeletal muscle metabolic gene expression","volume":"37","author":"McGee","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2023080307334089300_DMM049930C29","doi-asserted-by":"publisher","first-page":"e31583","DOI":"10.1371\/journal.pone.0031583","article-title":"LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation","volume":"7","author":"Mian","year":"2012","journal-title":"PLoS ONE"},{"key":"2023080307334089300_DMM049930C43","doi-asserted-by":"publisher","first-page":"e24826","DOI":"10.1371\/journal.pone.0024826","article-title":"A new extensively characterised conditionally immortal muscle cell-line for investigating therapeutic strategies in muscular dystrophies","volume":"6","author":"Muses","year":"2011","journal-title":"PLoS One"},{"key":"2023080307334089300_DMM049930C30","doi-asserted-by":"publisher","first-page":"e0237138","DOI":"10.1371\/journal.pone.0237138","article-title":"Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle","volume":"15","author":"Ramos","year":"2020","journal-title":"PLoS ONE"},{"key":"2023080307334089300_DMM049930C31","doi-asserted-by":"publisher","first-page":"104260","DOI":"10.1016\/j.phrs.2019.104260","article-title":"Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies","volume":"145","author":"Sanarica","year":"2019","journal-title":"Pharmacol. Res."},{"key":"2023080307334089300_DMM049930C32","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/stem.1788","article-title":"Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis","volume":"32","author":"Shan","year":"2014","journal-title":"Stem Cells"},{"key":"2023080307334089300_DMM049930C33","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1002\/jcp.25786","article-title":"Lkb1 regulation of skeletal muscle development, metabolism and muscle progenitor cell homeostasis: roles of Lkb1 in skeletal muscle and progenitors","volume":"232","author":"Shan","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"2023080307334089300_DMM049930C34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41392-020-00265-w","article-title":"The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis","volume":"5","author":"Sun","year":"2020","journal-title":"Sig. Transduct. Target Ther."},{"key":"2023080307334089300_DMM049930C35","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3390\/ijms19103125","article-title":"The role of AMPK in the regulation of skeletal muscle size, hypertrophy, and regeneration","volume":"19","author":"Thomson","year":"2018","journal-title":"IJMS"},{"key":"2023080307334089300_DMM049930C36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.celrep.2018.06.011","article-title":"CaMKK2 regulates mechanosensitive assembly of contractile actin stress fibers","volume":"24","author":"Tojkander","year":"2018","journal-title":"Cell Rep."},{"key":"2023080307334089300_DMM049930C37","doi-asserted-by":"publisher","first-page":"8110","DOI":"10.1096\/fj.201802488R","article-title":"Natural disease history of the D2-mdx mouse model for Duchenne muscular dystrophy","volume":"33","author":"van Putten","year":"2019","journal-title":"FASEB J."},{"key":"2023080307334089300_DMM049930C38","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.ajpath.2017.05.010","article-title":"Magnetic Resonance Monitoring of Disease Progression in mdx Mice on Different Genetic Backgrounds","volume":"187","author":"Vohra","year":"2017","journal-title":"Am. J. Pathol."},{"key":"2023080307334089300_DMM049930C39","doi-asserted-by":"publisher","first-page":"9345","DOI":"10.1074\/jbc.M113.456996","article-title":"The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases","volume":"288","author":"Walkinshaw","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2023080307334089300_DMM049930C40","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1128\/MCB.20.18.6904-6912.2000","article-title":"Regulation of histone deacetylase 4 by binding of 14-3-3 proteins","volume":"20","author":"Wang","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2023080307334089300_DMM049930C41","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3390\/ijms17101695","article-title":"CaMKK2 suppresses muscle regeneration through the inhibition of myoblast proliferation and differentiation","volume":"17","author":"Ye","year":"2016","journal-title":"IJMS"},{"key":"2023080307334089300_DMM049930C42","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1178377","article-title":"Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation","volume":"326","author":"Zeqiraj","year":"2009","journal-title":"Science"}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049930\/3099822\/dmm049930.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.049930\/3099822\/dmm049930.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T03:34:03Z","timestamp":1691033643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/16\/7\/dmm049930\/323412\/LKB1-signaling-is-altered-in-skeletal-muscle-of-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.049930","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"article-number":"dmm049930"}}