{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:53:41Z","timestamp":1773176021812,"version":"3.50.1"},"reference-count":44,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"crossref","award":["MOE2017-T3-1-002"],"award-info":[{"award-number":["MOE2017-T3-1-002"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Alzheimer's disease (AD) is a degenerative brain disorder with a long prodromal period. An APPNL-G-F knock-in mouse model is a preclinical model to study incipient pathologies during the early stages of AD. Despite behavioral tests revealing broad cognitive deficits in APPNL-G-F mice, detecting these impairments at the early disease phase has been challenging. In a cognitively demanding task that assessed episodic-like memory, 3-month-old wild-type mice could incidentally form and retrieve \u2018what\u2013where\u2013when\u2019 episodic associations of their past encounters. However, 3-month-old APPNL-G-F mice, corresponding to an early disease stage without prominent amyloid plaque pathology, displayed impairment in recalling \u2018what\u2013where\u2019 information of past episodes. Episodic-like memory is also sensitive to the effect of age. Eight-month-old wild-type mice failed to retrieve conjunctive \u2018what\u2013where\u2013when\u2019 memories. This deficit was also observed in 8-month-old APPNL-G-F mice. c-Fos expression revealed that impaired memory retrieval in APPNL-G-F mice was accompanied by abnormal neuronal hyperactivity in the medial prefrontal cortex and CA1 dorsal hippocampus. These observations can be used for risk stratification during preclinical AD to detect and delay the progression into dementia.<\/jats:p>","DOI":"10.1242\/dmm.049945","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T13:14:47Z","timestamp":1678454087000},"source":"Crossref","is-referenced-by-count":5,"title":["Impaired episodic-like memory in a mouse model of Alzheimer's disease is associated with hyperactivity in prefrontal\u2013hippocampal regions"],"prefix":"10.1242","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-7222","authenticated-orcid":false,"given":"Sijie","family":"Tan","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University 1 , Singapore 637551"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University 2 , Singapore 308232"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-9604","authenticated-orcid":false,"given":"Wen Han","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University 1 , Singapore 637551"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University 2 , Singapore 308232"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-6796","authenticated-orcid":false,"given":"Ajai","family":"Vyas","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University 1 , Singapore 637551"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"2023031013140807300_","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.bbr.2008.02.009","article-title":"A new test paradigm for social recognition evidenced by urinary scent marking behavior in C57BL\/6J mice","volume":"190","author":"Arakawa","year":"2008","journal-title":"Behav. 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