{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:16:20Z","timestamp":1771892180852,"version":"3.50.1"},"reference-count":110,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008532","name":"Universidade Federal do Rio Grande do Norte","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008532","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001688","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"crossref","award":["CRP\/BRA18\u221205_EC"],"award-info":[{"award-number":["CRP\/BRA18\u221205_EC"]}],"id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>An outbreak of births of microcephalic patients in Brazil motivated multiple studies on this incident. The data left no doubt that infection by Zika virus (ZIKV) was the cause, and that this virus promotes reduction in neuron numbers and neuronal death. Analysis of patients' characteristics revealed additional aspects of the pathology alongside the decrease in neuronal number. Here, we review the data from human, molecular, cell and animal model studies attempting to build the natural history of ZIKV in the embryonic central nervous system (CNS). We discuss how identifying the timing of infection and the pathways through which ZIKV may infect and spread through the CNS can help explain the diversity of phenotypes found in congenital ZIKV syndrome (CZVS). We suggest that intraneuronal viral transport is the primary mechanism of ZIKV spread in the embryonic brain and is responsible for most cases of CZVS. According to this hypothesis, the viral transport through the blood\u2013brain barrier and cerebrospinal fluid is responsible for more severe pathologies in which ZIKV-induced malformations occur along the entire anteroposterior CNS axis.<\/jats:p>","DOI":"10.1242\/dmm.050005","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T08:55:51Z","timestamp":1689584151000},"source":"Crossref","is-referenced-by-count":5,"title":["Zika virus infection histories in brain development"],"prefix":"10.1242","volume":"16","author":[{"given":"Bruna L. M.","family":"Marcelino","sequence":"first","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte 1 , 59056-450 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-9157","authenticated-orcid":false,"given":"Brendha L.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Rio de Janeiro \u2013 Rio de Janeiro 2 Morphological Sciences Program , , 21941-590 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-5868","authenticated-orcid":false,"given":"Jhulimar G.","family":"Doerl","sequence":"additional","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte 1 , 59056-450 Natal , Brazil"},{"name":"Federal University of Rio Grande do Norte 3 Neurosciences Graduate Program , , 59056-450 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha F.","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte 1 , 59056-450 Natal , Brazil"},{"name":"Federal University of Rio Grande do Norte 3 Neurosciences Graduate Program , , 59056-450 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara N.","family":"Maia","sequence":"additional","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte 1 , 59056-450 Natal , Brazil"},{"name":"Federal University of Rio Grande do Norte 3 Neurosciences Graduate Program , , 59056-450 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-311X","authenticated-orcid":false,"given":"Nivia M. R.","family":"Arrais","sequence":"additional","affiliation":[{"name":"Onofre Lopes University Hospital, Federal University of Rio Grande do Norte 4 Department of Pediatrics , , 59012-300 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7677-0034","authenticated-orcid":false,"given":"Andrea","family":"Zin","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, National Institute for Women's, Child and Adolescent Health Fernandes Figueira, Oswaldo Cruz Foundation 5 , 59056-450 Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-9904","authenticated-orcid":false,"given":"Selma M. B.","family":"Jeronimo","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte 6 , 59056-450 Natal , Brazil"},{"name":"National Institute of Science and Technology of Tropical Diseases 7 , Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-7702","authenticated-orcid":false,"given":"Claudio","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte 1 , 59056-450 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-5122","authenticated-orcid":false,"given":"Cecilia","family":"Hedin-Pereira","sequence":"additional","affiliation":[{"name":"Vice-Presidency of Research and Biological Collections (VPPCB), Oswaldo Cruz Foundation 8 , 21040-900 Rio de Janeiro , Brazil"},{"name":"National Institute for Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, 21040-900 Rio de Janeiro 9 , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-9843","authenticated-orcid":false,"given":"Eduardo B.","family":"Sequerra","sequence":"additional","affiliation":[{"name":"Brain Institute, Federal University of Rio Grande do Norte 1 , 59056-450 Natal , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"2023071708554212100_DMM050005C1","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3201\/eid2306.161702","article-title":"Severe neurologic disorders in 2 fetuses with Zika virus infection, Colombia","volume":"23","author":"Acosta-Reyes","year":"2017","journal-title":"Emerg. 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