{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:57:34Z","timestamp":1769507854972,"version":"3.49.0"},"reference-count":46,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070963"],"award-info":[{"award-number":["82070963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82121003"],"award-info":[{"award-number":["82121003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371083"],"award-info":[{"award-number":["82371083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Department of Sichuan Province","award":["23ZYKJCX0013"],"award-info":[{"award-number":["23ZYKJCX0013"]}]},{"name":"Science and Technology Department of Sichuan Province","award":["2023ZYD0172"],"award-info":[{"award-number":["2023ZYD0172"]}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"crossref","award":["2019-12M-5-032"],"award-info":[{"award-number":["2019-12M-5-032"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sichuan Provincial People's Hospital","award":["2022BH02"],"award-info":[{"award-number":["2022BH02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>N-methyl-D-aspartate (NMDA)-induced retinal damage has been well studied in rodents, but the detailed mechanisms have not yet been characterized in nonhuman primates. Here, we characterized the retinal degenerative effects of NMDA on rhesus monkeys in vivo. NMDA saline or saline-only control was injected intravitreally to the randomly assigned eyes and contralateral eyes of four rhesus monkeys, respectively. The structural and functional changes of retina were characterized by optical coherence tomography and electroretinography on days 0, 4, 30 and 60 post injection. Both optic discs and macular areas of the NMDA-injected eyes initially presented with a transient retinal thickening, followed by continued retinal thinning. The initial, transient retinal thickening has also been observed in glaucoma patients, but this has not been reported in rodent NMDA models. This initial response was followed by loss of retina ganglion cells (RGCs), which is similar to glaucomatous optic neuropathy and other RGC-related retinal degenerations. The amplitudes of both the photopic negative response and pattern electroretinogram decreased significantly and remained low until the end of the study. Thus, the NMDA monkey model may serve as a more clinically relevant animal model of retinal damage.<\/jats:p>","DOI":"10.1242\/dmm.050033","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T07:27:33Z","timestamp":1721978853000},"source":"Crossref","is-referenced-by-count":2,"title":["Characterization of a monkey model with experimental retinal damage induced by N-methyl-D-aspartate"],"prefix":"10.1242","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-4227","authenticated-orcid":false,"given":"Guo","family":"Liu","sequence":"first","affiliation":[{"name":"Sichuan Provincial People's Hospital 1 Sichuan Provincial Key Laboratory for Human Disease Gene Study , , , Chengdu, 610072 , China"},{"name":"University of Electronic Science and Technology of China 1 Sichuan Provincial Key Laboratory for Human Disease Gene Study , , , Chengdu, 610072 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-4221","authenticated-orcid":false,"given":"Longxiang","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Fujian Medical University 2 , Fuzhou, Fujian, 350005 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-1355","authenticated-orcid":false,"given":"Junkai","family":"Tan","sequence":"additional","affiliation":[{"name":"Xiamen Eye Center, Xiamen University 3 , Xiamen, 361004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-6242","authenticated-orcid":false,"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Jinan University 4 Shenzhen Key Laboratory of Ophthalmology , , Shenzhen, 518040 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-1704","authenticated-orcid":false,"given":"Chunlin","family":"Lan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Fujian Medical University 2 , Fuzhou, Fujian, 350005 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8578-5020","authenticated-orcid":false,"given":"Yaxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Jinan University 4 Shenzhen Key Laboratory of Ophthalmology , , Shenzhen, 518040 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2734-2694","authenticated-orcid":false,"given":"Yukai","family":"Mao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Fujian Medical University 2 , Fuzhou, Fujian, 350005 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-0530","authenticated-orcid":false,"given":"Xizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Jinan University 4 Shenzhen Key Laboratory of Ophthalmology , , Shenzhen, 518040 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-4441","authenticated-orcid":false,"given":"Ning","family":"Fan","sequence":"additional","affiliation":[{"name":"Shenzhen Eye Hospital, Jinan University 4 Shenzhen Key Laboratory of Ophthalmology , , Shenzhen, 518040 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-669X","authenticated-orcid":false,"given":"Yihua","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Fujian Medical University 2 , Fuzhou, Fujian, 350005 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2531-7552","authenticated-orcid":false,"given":"Xianjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sichuan Provincial People's Hospital 1 Sichuan Provincial Key Laboratory for Human Disease Gene Study , , , Chengdu, 610072 , China"},{"name":"University of Electronic Science and Technology of China 1 Sichuan Provincial Key Laboratory for Human Disease Gene Study , , , Chengdu, 610072 , China"},{"name":"Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital 5 , Chengdu, Sichuan, 610072 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-0098","authenticated-orcid":false,"given":"Xuyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen Eye Center, Xiamen University 3 , Xiamen, 361004 , China"},{"name":"Shenzhen People's Hospital, the 2nd Clinical Medical College, Jinan University 6 Department of Ophthalmology , , Shenzhen, 518020 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"2024091813195632700_DMM050033C1","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00401-011-0807-1","article-title":"The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma","volume":"121","author":"Chidlow","year":"2011","journal-title":"Acta Neuropathol."},{"key":"2024091813195632700_DMM050033C2","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1167\/iovs.17-23387","article-title":"Retinal nerve fiber layer features identified by unsupervised machine learning on optical coherence tomography scans predict glaucoma progression","volume":"59","author":"Christopher","year":"2018","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1017\/S0952523800001668","article-title":"The role of NMDA and non-NMDA excitatory amino acid receptors in the functional organization of primate retinal ganglion cells","volume":"11","author":"Cohen","year":"1994","journal-title":"Vis. Neurosci."},{"key":"2024091813195632700_DMM050033C4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1017\/S0952523813000461","article-title":"A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina","volume":"31","author":"Crook","year":"2014","journal-title":"Vis. Neurosci."},{"key":"2024091813195632700_DMM050033C5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10633-021-09854-8","article-title":"Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT","volume":"144","author":"Cvenkel","year":"2022","journal-title":"Doc. Ophthalmol."},{"key":"2024091813195632700_DMM050033C6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1001\/jamaophthalmol.2017.6256","article-title":"Disorganization of inner retina and outer retinal morphology in diabetic macular edema","volume":"136","author":"Das","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"2024091813195632700_DMM050033C7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10633-018-9638-x","article-title":"ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram","volume":"136","author":"Frishman","year":"2018","journal-title":"Doc. Ophthalmol."},{"key":"2024091813195632700_DMM050033C8","doi-asserted-by":"publisher","first-page":"15859","DOI":"10.1523\/JNEUROSCI.0038-12.2012","article-title":"Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma","volume":"32","author":"Fu","year":"2012","journal-title":"J. Neurosci."},{"key":"2024091813195632700_DMM050033C9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1097\/WCO.0000000000000777","article-title":"Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions","volume":"33","author":"Gokoffski","year":"2020","journal-title":"Curr. Opin. Neurol."},{"key":"2024091813195632700_DMM050033C10","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1006\/exnr.1998.6881","article-title":"Glutamate receptor subunit GluR2 and NMDAR1 immunoreactivity in the retina of macaque monkeys with experimental glaucoma does not identify vulnerable neurons","volume":"153","author":"Hof","year":"1998","journal-title":"Exp. Neurol."},{"key":"2024091813195632700_DMM050033C11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1136\/bjo.71.3.166","article-title":"Significance of abnormal pattern electroretinography in anterior visual pathway dysfunction","volume":"71","author":"Holder","year":"1987","journal-title":"Br. J. Ophthalmol."},{"key":"2024091813195632700_DMM050033C12","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S1350-9462(00)00030-6","article-title":"Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis","volume":"20","author":"Holder","year":"2001","journal-title":"Prog. Retin Eye Res."},{"key":"2024091813195632700_DMM050033C44","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1167\/iovs.19-27145","article-title":"Survival of alpha and intrinsically photosensitive retinal ganglion cells in NMDA-induced neurotoxicity and a mouse model of normal tension glaucoma","volume":"60","author":"Honda","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C13","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1016\/S0042-6989(98)00296-X","article-title":"Identifying inner retinal contributions to the human multifocal ERG","volume":"39","author":"Hood","year":"1999","journal-title":"Vision Res."},{"key":"2024091813195632700_DMM050033C14","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3390\/ijms21030981","article-title":"Modulation of AMPA receptors by nitric oxide in nerve cells","volume":"21","author":"Ivanova","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2024091813195632700_DMM050033C15","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/NEN.0b013e31824deb21","article-title":"Hypoxia-induced activation of N-methyl-D-aspartate receptors causes retinal ganglion cell death in the neonatal retina","volume":"71","author":"Kaur","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2024091813195632700_DMM050033C16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2131\/jts.45.261","article-title":"Outer retinal involvement in N-methyl-D-aspartate-induced inner retinal injury in rabbits assessed by optical coherence tomography","volume":"45","author":"Kinoshita","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"2024091813195632700_DMM050033C17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/nrendo.2017.161","article-title":"Animal models of obesity and diabetes mellitus","volume":"14","author":"Kleinert","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"2024091813195632700_DMM050033C18","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/s41433-020-1006-x","article-title":"The agreement between optical coherence tomography angiography and non-mydriatic retinal camera in estimating the optic nerve head parameters and relations with the peripapillary vessel density in primary open-angle glaucoma","volume":"35","author":"Koylu","year":"2021","journal-title":"Eye (Lond)"},{"key":"2024091813195632700_DMM050033C19","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1001\/archophthalmol.2012.669","article-title":"Distribution of damage to the entire retinal ganglion cell pathway: quantified using spectral-domain optical coherence tomography analysis in patients with glaucoma","volume":"130","author":"Lee","year":"2012","journal-title":"Arch Ophthalmol."},{"key":"2024091813195632700_DMM050033C43","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.3390\/ijms24043126","article-title":"Origin of retinal oscillatory potentials in the mouse, a tool to specifically locate retinal damage","volume":"24","author":"Liao","year":"2023","journal-title":"Int. J. Mol. Sci"},{"key":"2024091813195632700_DMM050033C20","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12974-022-02626-4","article-title":"GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1\/RIP3\/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"2024091813195632700_DMM050033C21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1167\/iovs.05-0272","article-title":"Retinal thickness and subnormal retinal oxygenation response in experimental diabetic retinopathy","volume":"47","author":"Luan","year":"2006","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C22","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.1167\/iovs.08-1946","article-title":"Photopic negative response of focal electoretinograms in glaucomatous eyes","volume":"49","author":"Machida","year":"2008","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C23","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1097\/WNO.0000000000000295","article-title":"Intracranial pressure and glaucoma","volume":"35","author":"McCulley","year":"2015","journal-title":"J. Neuroophthalmol."},{"key":"2024091813195632700_DMM050033C24","doi-asserted-by":"publisher","first-page":"117700","DOI":"10.1016\/j.neuroimage.2020.117700","article-title":"International primate neuroscience research regulation, public engagement and transparency opportunities","volume":"229","author":"Mitchell","year":"2021","journal-title":"Neuroimage"},{"key":"2024091813195632700_DMM050033C25","doi-asserted-by":"publisher","first-page":"e115291","DOI":"10.1371\/journal.pone.0115291","article-title":"Ganglion cell and displaced amacrine cell density distribution in the retina of the howler monkey (Alouatta caraya)","volume":"9","author":"Muniz","year":"2014","journal-title":"PLoS One"},{"key":"2024091813195632700_DMM050033C26","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1038\/eye.2016.190","article-title":"Clinical evaluation of microcystic macular edema in patients with glaucoma","volume":"30","author":"Murata","year":"2016","journal-title":"Eye (Lond)"},{"key":"2024091813195632700_DMM050033C27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3390\/ijms17010110","article-title":"Retinal cell degeneration in animal models","volume":"17","author":"Niwa","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2024091813195632700_DMM050033C28","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/ajp.22281","article-title":"Why primate models matter","volume":"76","author":"Phillips","year":"2014","journal-title":"Am. J. Primatol."},{"key":"2024091813195632700_DMM050033C29","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1167\/iovs.06-0733","article-title":"The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA\/2J mouse model of glaucoma","volume":"48","author":"Porciatti","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C30","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1167\/iovs.03-0009","article-title":"Regional variations in local contributions to the primate photopic flash ERG: revealed using the slow-sequence mfERG","volume":"44","author":"Rangaswamy","year":"2003","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C31","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1167\/iovs.04-0458","article-title":"Photopic ERGs in patients with optic neuropathies: comparison with primate ERGs after pharmacologic blockade of inner retina","volume":"45","author":"Rangaswamy","year":"2004","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-017-9621-y","article-title":"ISCEV guide to visual electrodiagnostic procedures","volume":"136","author":"Robson","year":"2018","journal-title":"Doc. Ophthalmol."},{"key":"2024091813195632700_DMM050033C33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10633-022-09872-0","article-title":"ISCEV Standard for full-field clinical electroretinography (2022 update)","volume":"144","author":"Robson","year":"2022","journal-title":"Doc. Ophthalmol."},{"key":"2024091813195632700_DMM050033C34","doi-asserted-by":"publisher","first-page":"22879","DOI":"10.1038\/s41598-021-02048-x","article-title":"PERG adaptation for detection of retinal ganglion cell dysfunction in glaucoma: a pilot diagnostic accuracy study","volume":"11","author":"Salgarello","year":"2021","journal-title":"Sci. Rep."},{"key":"2024091813195632700_DMM050033C35","first-page":"1025","article-title":"Primate models for cardiovascular drug research and development","volume":"11","author":"Shen","year":"2010","journal-title":"Curr. Opin. Investig Drugs"},{"key":"2024091813195632700_DMM050033C36","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.exer.2005.08.001","article-title":"Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys","volume":"82","author":"Shimazawa","year":"2006","journal-title":"Exp. Eye Res."},{"key":"2024091813195632700_DMM050033C46","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1364\/OL.514637","article-title":"Chirped flicker optoretinography for in vivo characterization of human photoreceptors' frequency response to light","volume":"49","author":"Tomczewski","year":"2024","journal-title":"Opt. Lett"},{"key":"2024091813195632700_DMM050033C37","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1167\/iovs.03-0657","article-title":"Luminance dependence of neural components that underlies the primate photopic electroretinogram","volume":"45","author":"Ueno","year":"2004","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2024091813195632700_DMM050033C38","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.visres.2005.05.026","article-title":"Contribution of retinal neurons to d-wave of primate photopic electroretinograms","volume":"46","author":"Ueno","year":"2006","journal-title":"Vision Res."},{"key":"2024091813195632700_DMM050033C39","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1023\/A:1020505104334","article-title":"Inner-retinal contributions to the photopic sinusoidal flicker electroretinogram of macaques. Macaque photopic sinusoidal flicker ERG","volume":"105","author":"Viswanathan","year":"2002","journal-title":"Doc. Ophthalmol."},{"key":"2024091813195632700_DMM050033C40","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3390\/cells9040882","article-title":"Large animal models of inherited retinal degenerations: a review","volume":"9","author":"Winkler","year":"2020","journal-title":"Cells"},{"key":"2024091813195632700_DMM050033C45","doi-asserted-by":"publisher","first-page":"eaay3302","DOI":"10.1126\/science.aay3302","article-title":"Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants","volume":"370","author":"Yan","year":"2020","journal-title":"Science"},{"key":"2024091813195632700_DMM050033C41","doi-asserted-by":"publisher","first-page":"12753","DOI":"10.3390\/ijms232112753","article-title":"Neuroprotective effects of transferrin in experimental glaucoma models","volume":"23","author":"Youale","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2024091813195632700_DMM050033C42","doi-asserted-by":"publisher","first-page":"447","DOI":"10.13918\/j.issn.2095-8137.2014.6.447","article-title":"Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress","volume":"35","author":"Zhang","year":"2014","journal-title":"Dongwuxue Yanjiu"}],"container-title":["Disease Models &amp; Mechanisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.050033\/3566595\/dmm050033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dmm\/article-pdf\/doi\/10.1242\/dmm.050033\/3566595\/dmm050033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T13:20:19Z","timestamp":1726665619000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dmm\/article\/17\/8\/dmm050033\/361266\/Characterization-of-a-monkey-model-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dmm.050033","relation":{},"ISSN":["1754-8403","1754-8411"],"issn-type":[{"value":"1754-8403","type":"print"},{"value":"1754-8411","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,26]]},"article-number":"dmm050033"}}