{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:10:42Z","timestamp":1793063442940,"version":"4.5.0"},"reference-count":81,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University Grants Commission","award":["F. 6-10\/2017(IC)]"],"award-info":[{"award-number":["F. 6-10\/2017(IC)]"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["IA\/I\/15\/2\/502091"],"award-info":[{"award-number":["IA\/I\/15\/2\/502091"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007488","name":"Indian Institute of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007488","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Under normal physiological conditions, the mammalian brain contains very little glycogen, most of which is stored in astrocytes. However, the aging brain and the subareas of the brain in patients with neurodegenerative disorders tend to accumulate glycogen, the cause and significance of which remain largely unexplored. Using cellular models, we have recently demonstrated a neuroprotective role for neuronal glycogen and glycogen synthase in the context of Huntington's disease. To gain insight into the role of brain glycogen in regulating proteotoxicity, we utilized a Drosophila model of Huntington's disease, in which glycogen synthase is either knocked down or expressed ectopically. Enhancing glycogen synthesis in the brains of flies with Huntington's disease decreased mutant Huntingtin aggregation and reduced oxidative stress by activating auto-lysosomal functions. Further, overexpression of glycogen synthase in the brain rescues photoreceptor degeneration, improves locomotor deficits and increases fitness traits in this Huntington's disease model. We, thus, provide in vivo evidence for the neuroprotective functions of glycogen synthase and glycogen in neurodegenerative conditions, and their role in the neuronal autophagy process.<\/jats:p>","DOI":"10.1242\/dmm.050238","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T03:58:58Z","timestamp":1694145538000},"source":"Crossref","is-referenced-by-count":14,"title":["Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in\n                    <i>Drosophila<\/i>"],"prefix":"10.1242","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-6450","authenticated-orcid":false,"given":"Akanksha","family":"Onkar","sequence":"first","affiliation":[{"name":"Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9582-5643","authenticated-orcid":false,"given":"Deepashree","family":"Sheshadri","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India"},{"name":"Centre of Excellence in Neuroscience, Neurotechnology, and Mental Health, Gangwal School of Medical Sciences and Technology, 2 IIT, Kanpur 208016 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Rai","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjit Kant","family":"Gupta","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-3848","authenticated-orcid":false,"given":"Nitin","family":"Gupta","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India"},{"name":"Centre of Excellence in Neuroscience, Neurotechnology, and Mental Health, Gangwal School of Medical Sciences and Technology, 2 IIT, Kanpur 208016 , India"},{"name":"The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology 3 , Kanpur 208016 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-9177","authenticated-orcid":false,"given":"Subramaniam","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology 1 Department of Biological Sciences and Bioengineering , (IIT), Kanpur 208016 , India"},{"name":"Centre of Excellence in Neuroscience, Neurotechnology, and Mental Health, Gangwal School of Medical Sciences and Technology, 2 IIT, Kanpur 208016 , India"},{"name":"The Mehta Family Centre for Engineering in Medicine, Indian Institute of Technology 3 , Kanpur 208016 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"2023101911012568300_DMM050238C1","doi-asserted-by":"publisher","first-page":"41807","DOI":"10.1038\/srep41807","article-title":"New perspectives on corpora amylacea in the human brain","volume":"7","author":"Aug\u00e9","year":"2017","journal-title":"Sci. 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