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Recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxic mouse model generated by silencing Purkinje cell neurotransmission (L7Cre;Vgatfx\/fx) to better understand how cerebellar dysfunction impacts sleep physiology. We focused our analysis on sleep architecture and electrocorticography (ECoG) patterns based on their relevance to extracting physiological measurements during sleep. We found that circadian activity was unaltered in the mutant mice, although their sleep parameters and ECoG patterns were modified. The L7Cre;Vgatfx\/fx mutant mice had decreased wakefulness and rapid eye movement (REM) sleep, whereas non-REM sleep was increased. The mutants had an extended latency to REM sleep, which is also observed in human patients with ataxia. Spectral analysis of ECoG signals revealed alterations in the power distribution across different frequency bands defining sleep. Therefore, Purkinje cell dysfunction may influence wakefulness and equilibrium of distinct sleep stages in ataxia. Our findings posit a connection between cerebellar dysfunction and disrupted sleep and underscore the importance of examining cerebellar circuit function in sleep disorders.<\/jats:p>","DOI":"10.1242\/dmm.050379","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:47:26Z","timestamp":1712051246000},"source":"Crossref","is-referenced-by-count":12,"title":["Purkinje cell dysfunction causes disrupted sleep in ataxic mice"],"prefix":"10.1242","volume":"17","author":[{"given":"Luis E.","family":"Salazar Leon","sequence":"first","affiliation":[{"name":"Baylor College of Medicine 1 Department of Neuroscience , , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 2 Department of Pathology and Immunology , , Houston, TX 77030 , USA"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital 3 , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine 2 Department of Pathology and Immunology , , Houston, TX 77030 , USA"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital 3 , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heet","family":"Kaku","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine 1 Department of Neuroscience , , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-6190","authenticated-orcid":false,"given":"Roy V.","family":"Sillitoe","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine 1 Department of Neuroscience , , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 2 Department of Pathology and Immunology , , Houston, TX 77030 , USA"},{"name":"Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital 3 , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 4 Department of Pediatrics , , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 5 Development, Disease Models and Therapeutics Graduate Program , , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"2024062510010066800_DMM050379C1","doi-asserted-by":"publisher","first-page":"107913","DOI":"10.1016\/j.neuropharm.2019.107913","article-title":"Dose-dependent alcohol effects on electroencephalogram: sedation\/anesthesia is qualitatively distinct from sleep","volume":"164","author":"Abrahao","year":"2020","journal-title":"Neuropharmacology"},{"key":"2024062510010066800_DMM050379C2","doi-asserted-by":"publisher","first-page":"zsx088","DOI":"10.1093\/sleep\/zsx088","article-title":"Modulation of the muscle activity during sleep in cervical dystonia","volume":"40","author":"Antelmi","year":"2017","journal-title":"Sleep"},{"key":"2024062510010066800_DMM050379C3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.12871\/00039829201833","article-title":"Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes","volume":"156","author":"Bjorness","year":"2018","journal-title":"Arch. 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