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Metals, such as copper, iron and zinc, are critical for various biological and cellular processes across phyla. In mammals, these metals are important determinants of immune responses, but pathogenic microbes, including fungi, also require access to these metals to fuel their own growth and drive expression of major virulence traits. Therefore, host immune cells have developed strategies to either restrict access to metals to induce starvation of invading pathogens or deploy toxic concentrations within phagosomes to cause metal poisoning. In this Review, we describe the mechanisms regulating fungal scavenging and detoxification of copper, iron and zinc and the importance of these mechanisms for virulence and infection. We also outline how these metals are involved in host immune responses and the consequences of metal deficiencies or overloads on how the host controls invasive fungal infections.<\/jats:p>","DOI":"10.1242\/dmm.050393","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:34:00Z","timestamp":1698726840000},"source":"Crossref","is-referenced-by-count":18,"title":["How metals fuel fungal virulence, yet promote anti-fungal immunity"],"prefix":"10.1242","volume":"16","author":[{"given":"Alanoud","family":"Alselami","sequence":"first","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham 1 , Birmingham B15 2TT ,","place":["UK"]},{"name":"Biology Department, University Collage of Aldarb, Jazan University 2 , Jazan 45142 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7074","authenticated-orcid":false,"given":"Rebecca A.","family":"Drummond","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, University of Birmingham 1 , Birmingham B15 2TT ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"2026010805170031500_DMM050393C1","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.4103\/jfmpc.jfmpc_599_19","article-title":"Does anemia affects cognitive functions in neurologically intact adult patients: Two year cross sectional study at rural tertiary care hospital","volume":"8","author":"Agrawal","year":"2019","journal-title":"J. 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