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Although an important human pathogen, the host response to S. flexneri has not been fully described. Zebrafish larvae represent a valuable model for studying human infections in vivo. Here, we use a Shigella-zebrafish infection model to generate mRNA expression profiles of host response to Shigella infection at the whole-animal level. Immune response-related processes dominate the signature of early Shigella infection (6\u2005h post-infection). Consistent with its clearance from the host, the signature of late Shigella infection (24\u2005h post-infection) is significantly changed, and only a small set of immune-related genes remain differentially expressed, including acod1 and gpr84. Using mutant lines generated by ENU, CRISPR mutagenesis and F0 crispants, we show that acod1- and gpr84-deficient larvae are more susceptible to Shigella infection. Together, these results highlight the power of zebrafish to model infection by bacterial pathogens and reveal the mRNA expression of the early (acutely infected) and late (clearing) host response to Shigella infection.<\/jats:p>","DOI":"10.1242\/dmm.050431","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:13:56Z","timestamp":1703218436000},"source":"Crossref","is-referenced-by-count":2,"title":["Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to\n                    <i>Shigella flexneri<\/i>"],"prefix":"10.1242","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-0249","authenticated-orcid":false,"given":"Vincenzo","family":"Torraca","sequence":"first","affiliation":[{"name":"London School of Hygiene & Tropical Medicine 1 Department of Infection Biology , , London WC1E 7HT , UK"},{"name":"MRC Centre for Molecular Bacteriology and Infection, Imperial College London 2 Section of Microbiology , , London SW7 2AZ , UK"},{"name":"School of Immunology and Microbial Sciences, King's College London 3 Department of Infectious Diseases , , London SE1 9RT , UK"},{"name":"University of Westminster 4 School of Life Sciences , , London W1W 6UW , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-412X","authenticated-orcid":false,"given":"Richard J.","family":"White","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge 5 , Cambridge CB2 0AW , UK"},{"name":"Queen Mary University of London 6 School of Biological and Behavioural Sciences, Faculty of Science and Engineering , , London E1 4NS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-6635","authenticated-orcid":false,"given":"Ian M.","family":"Sealy","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge 5 , Cambridge CB2 0AW , UK"},{"name":"Queen Mary University of London 6 School of Biological and Behavioural Sciences, Faculty of Science and Engineering , , London E1 4NS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-3266","authenticated-orcid":false,"given":"Maria","family":"Mazon-Moya","sequence":"additional","affiliation":[{"name":"MRC Centre for Molecular Bacteriology and Infection, Imperial College London 2 Section of Microbiology , , London SW7 2AZ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Duggan","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine 1 Department of Infection Biology , , London WC1E 7HT , UK"},{"name":"MRC Centre for Molecular Bacteriology and Infection, Imperial College London 2 Section of Microbiology , , London SW7 2AZ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-9580","authenticated-orcid":false,"given":"Alexandra R.","family":"Willis","sequence":"additional","affiliation":[{"name":"MRC Centre for Molecular Bacteriology and Infection, Imperial College London 2 Section of Microbiology , , London SW7 2AZ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-744X","authenticated-orcid":false,"given":"Elisabeth M.","family":"Busch-Nentwich","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge 5 , Cambridge CB2 0AW , UK"},{"name":"Queen Mary University of London 6 School of Biological and Behavioural Sciences, Faculty of Science and Engineering , , London E1 4NS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-6503","authenticated-orcid":false,"given":"Serge","family":"Mostowy","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine 1 Department of Infection Biology , , London WC1E 7HT , UK"},{"name":"MRC Centre for Molecular Bacteriology and Infection, Imperial College London 2 Section of Microbiology , , London SW7 2AZ , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"2024012608492521200_DMM050431C1","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1093\/bioinformatics\/btl140","article-title":"Improved scoring of functional groups from gene expression data by decorrelating GO graph 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