{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:29:39Z","timestamp":1788881379670,"version":"build-2803163510"},"reference-count":386,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NIHR Biomedical Research Centre at Guy's and St Thomas\u2019 NHS Foundation Trust and King's College London","award":["IS-BRC-1215-20006"],"award-info":[{"award-number":["IS-BRC-1215-20006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The association between ear and kidney anomalies has long been recognized. However, little is known about the underlying mechanisms. In the last two decades, embryonic development of the inner ear and kidney has been studied extensively. Here, we describe the developmental pathways shared between both organs with particular emphasis on the genes that regulate signalling cross talk and the specification of progenitor cells and specialised cell types. We relate this to the clinical features of oto-renal syndromes and explore links to developmental mechanisms.<\/jats:p>","DOI":"10.1242\/dmm.050447","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T04:30:50Z","timestamp":1707885050000},"source":"Crossref","is-referenced-by-count":7,"title":["Shared features in ear and kidney development \u2013 implications for oto-renal syndromes"],"prefix":"10.1242","volume":"17","author":[{"given":"Scarlet Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King's College London , London SE1 9RT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7664-7917","authenticated-orcid":false,"given":"Andrea","family":"Streit","sequence":"additional","affiliation":[{"name":"Centre for Craniofacial and Regenerative Biology, King's College London , London SE1 9RT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"2024021409303864800_DMM050447C1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/ng0297-157","article-title":"A human homologue of the Drosophila eyes absent gene underlies branchio- oto-renal (BOR) syndrome and identifies a novel gene family","volume":"15","author":"Abdelhak","year":"1997","journal-title":"Nat. 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