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Using a C57Bl\/6 mouse model in which decidualized endometrial tissue is injected subcutaneously in the abdomen of recipient mice, we generated a comprehensive profile of gene expression in decidualized endometrial tissue (n=4), and in endometriosis-like lesions at Day 7 (n=4) and Day 14 (n=4) of formation. High-throughput mRNA sequencing allowed identification of genes and pathways involved in the initiation and progression of endometriosis-like lesions. We observed distinct patterns of gene expression with substantial differences between the lesions and the decidualized endometrium that remained stable across the two lesion timepoints, and showed similarity to transcriptional changes implicated in human endometriosis lesion formation. Pathway enrichment analysis revealed several immune and inflammatory response-associated canonical pathways, multiple potential upstream regulators, and involvement of genes not previously implicated in endometriosis pathogenesis, including IRF2BP2 and ZBTB10, suggesting novel roles in disease progression. Collectively, the provided data will be a useful resource to inform research on the molecular mechanisms contributing to endometriosis-like lesion development in this mouse model.<\/jats:p>","DOI":"10.1242\/dmm.050566","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:43:16Z","timestamp":1728560596000},"source":"Crossref","is-referenced-by-count":2,"title":["RNA sequencing reveals molecular mechanisms of endometriosis lesion development in mice"],"prefix":"10.1242","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-819X","authenticated-orcid":false,"given":"Kavita","family":"Panir","sequence":"first","affiliation":[{"name":"Robinson Research Institute and School of Biomedicine, The University of Adelaide 1 , Adelaide, SA 5006 ,","place":["Australia"]},{"name":"Adelaide Medical School 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"University of Adelaide 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-6160","authenticated-orcid":false,"given":"John E.","family":"Schjenken","sequence":"additional","affiliation":[{"name":"Robinson Research Institute and School of Biomedicine, The University of Adelaide 1 , Adelaide, SA 5006 ,","place":["Australia"]},{"name":"Adelaide Medical School 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"University of Adelaide 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"School of Environmental and Life Sciences, College of Engineering, Science and Environment, The University of Newcastle 3 , Callaghan, NSW 2308 ,","place":["Australia"]},{"name":"Infertility and Reproduction Research Program, Hunter Medical Research Institute 4 , New Lambton Heights, NSW 2305 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-0925","authenticated-orcid":false,"given":"James","family":"Breen","sequence":"additional","affiliation":[{"name":"Robinson Research Institute and School of Biomedicine, The University of Adelaide 1 , Adelaide, SA 5006 ,","place":["Australia"]},{"name":"Adelaide Medical School 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"University of Adelaide 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"South Australian Genomics Centre (SAGC), South Australian Health and Medical Research Institute (SAHMRI) 5 , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"South Australian Health and Medical Research Institute (SAHMRI) 6 Computational and Systems Biology Program, Precision Medicine Theme , , Adelaide, SA 5000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-2094","authenticated-orcid":false,"given":"Hon Yeung","family":"Chan","sequence":"additional","affiliation":[{"name":"Robinson Research Institute and School of Biomedicine, The University of Adelaide 1 , Adelaide, SA 5006 ,","place":["Australia"]},{"name":"Adelaide Medical School 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"University of Adelaide 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-5851","authenticated-orcid":false,"given":"Erin","family":"Greaves","sequence":"additional","affiliation":[{"name":"Centre for Early Life 7 , Division of Biomedical Sciences , ,","place":["UK"]},{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL 7 , Division of Biomedical Sciences , ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9967-0084","authenticated-orcid":false,"given":"Sarah A.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Robinson Research Institute and School of Biomedicine, The University of Adelaide 1 , Adelaide, SA 5006 ,","place":["Australia"]},{"name":"Adelaide Medical School 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]},{"name":"University of Adelaide 2 , Faculty of Health and Medical Sciences , , Adelaide, SA 5000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1813-3971","authenticated-orcid":false,"given":"M. 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